Sentences with word «pleiotropic»
"Pleiotropic" refers to the genetic phenomenon where a single gene has multiple effects or influences on different traits or characteristics. Full definition
We hope to further investigate the effects of different OHS treatments on early gene activity in mice to explore the genetic basis of pleiotropic effects associated with cervical ribs.
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IL - 6 has pleiotropic roles during tumor progression and metastasis that include increased tumor cell survival, expansion of breast cancer stem cells, and resistance to targeted therapies (52).
In particular, the role of pleiotropic constraints and selection in shaping the adaptive evolution of body plans.
Without going into detail, other mediating processes in the CR, CO context may involve pleiotropic genes like dopamine receptor D4 (DRD4), involved in varied neurobiological processes and psychiatric / neurological phenotypes, including reaction to stress [85].
RhoA / ROCK Signaling and Pleiotropic a1A - Adrenergic Receptor Regulation of Cardiac Contractility.
Current knowledge suggests that the majority of biologically active compounds interact with multiple molecular targets exhibiting pleiotropic pharmacological actions.
Combining metabolic profiling with genomics using biobank cohorts can reveal early molecular insights into drug target biology and characterize pleiotropic effects.
135/6: 00 Exome - wide study identifies loci displaying pleiotropic associations with multiple cardiometabolic traits in continental Africans.
First, genetic effects are extremely pleiotropic.
39/3: 30 Multivariate analysis of whole exome sequence data identifies rare variants with pleiotropic effects on obesity - related metabolic traits in 31,000 participants of the Regeneron Genetics Center — Geisinger MyCode collaborative project — DiscovEHR.
Pleiotropic effects of fatty acids on pancreatic beta - cells.
The authors comment, «The work by Smit et al raises the exciting possibility that the pleiotropic effects of statins may also harbor important antimicrobial effects that may exert a clinically relevant benefit by conferring resistance to CA - SAB.»
IL - 15 is a pleiotropic cytokine, with proposed roles in both lymphoid and non-lymphoid tissues.
High - Throughput Screening Identifies miR - 451 as a Pleiotropic Modulator That Suppresses Gastric Cancer Metastasis.
We use multiple mouse models combined with in vitro approaches to address the pleiotropic functions of these cytokines which affect both the epithelial cancer cells and the inflammatory infiltrate within tumors.
The novel reprogramming approach employed the retroviral transduction of Oct4, Sox2, and Klf4 in mouse embryonic and adult fibroblasts followed by treatment with the GSK3β Inhibitor BIO and the pleiotropic cytokine Oncostatin M (OSM).
We have also studied developmental constraints in dogs, i.e. the negative consequences (pleiotropic effects) associated with extreme artificial selection for size in dogs (Collaboration with Marc Nussbaumer of the Natural History Museum, Berne, Switzerland).
However, it has become apparent that the activation of classic JAK - STAT pathways alone can not account for the pleiotropic biological effects of IFNs on target cells.
IL - 6 is a pleiotropic pro-inflammatory cytokine produced by a variety of cell types including T - and B - cells, lymphocytes, monocytes and fibroblasts.
Because of its pleiotropic functions, defects in human cohesin biology can cause a number of clinically relevant issues.
The antagonistic pleiotropic theory first proposed by Williams in 1957 states that aging is the result of the natural selection of many genes with pleiotropic function that benefit the young but will have an adverse effect later in life.
The two studies on this statin drug benefit for cardiac bypass by Curtis and Barakat refer to the anti-inflammatory «pleiotropic effects» of statin drugs.
Remember, the secret sauce to rebuilding your gut is what's called a Pleiotropic Approach.
Pleiotropic (pli - e-trop-ik) is a fancy idea that comes from Chinese medicine.
The osteosclerosis, an abnormal increased density of bone, is apparently a pleiotropic effect of the homozygous presence of the deficiency gene.
Moderating effects on IL6 and TBARS were, on the other hand, pleiotropic, as it was significant in almost all subscales, with the only exceptions being depressive and oppositional defiant problems, for IL6, and somatic problems, for TBARS (Table 3).