Sentences with phrase «pluripotency at»
They were also able to express markers of the three germ layers, suggesting that they re-established pluripotency at the molecular and cellular levels (Fig. 2I).
http://journals.plos.org/ Not exact matches
Suggesting that the November 2007 paper describing the induction of pluripotency in adult cells represents an endpoint in the stem - cell debate demonstrates a misreading of both the fundamental issue in the debate as well as where stem - cell research, at least in this country, is heading.
«Human embryonic stem cells remain the gold standard for pluripotency,» Francis Collins, director of the National Institutes of Health, said at the hearing.
► On Wednesday at ScienceInsider, Dennis Normile reported that stem cell scientist Haruko Obokata (lead author of the two STAP — stimulus - triggered acquisition of pluripotency — papers in Nature) «has agreed to retract the two Nature papers that reported her work.»
The committee's final report (in Japanese), released today, is the latest blow against a surprisingly simple method for creating stem cells, known as STAP (stimulus - triggered acquisition of pluripotency), published in a Nature article and an accompanying letter online on 29 January by Obokata and colleagues at RIKEN CDB, along with other institutions in Japan and at Harvard Medical School in Boston.
The exploration of the therapeutic potential of stem cells requires the characterization of their biological properties, the deciphering of the mechanisms that underlie their pluripotency and their capacity at differentiation, by the understanding of the signals that direct their fate towards discrete cell phenotypes... Their therapeutic use requests further, in particular in the case of substitutive therapies, the analysis of their capacities of integration in injured adult tissues and of their potential tumorigenicity, as well as the development of original ways of delivery.
OSKM work by binding to the genome at critical places, such as a stretch of genes that help determine the identity of the cell or that enhance and promote pluripotency.
July 2009 - Switching on the power of stem cells Cambridge scientists reveal how the protein Nanog gives stem cells their unique abilities Researchers from the Wellcome Trust Centre for Stem Cell Research at the University of Cambridge have pinpointed the role of the protein Nanog in a complex process that gives stem cells pluripotency: the ability to produce all the different cell types of the body.
These data show that pluripotency markers in the expanded clones are maintained at levels comparable to those in the parental line, ChiPSC18.
New research at the Hebrew University of Jerusalem sheds light on pluripotency — the ability of embryonic stem cells to renew themselves...
She joined Dr. Rik Derynck's lab at the University of California San Francisco, as a postdoctoral researcher to explore the mechanisms of TGF - b signaling for the maintenance of human ES / iPS cell pluripotency.
Dr. Manzanares is a senior scientist at the CNIC in Madrid, where his research group is studying the evolution of embryonic pluripotency in vertebrates.
«This discovery will advance our understanding of stem cell epigenetics and chromatin structures, provide potential mechanisms on maintaining the hallmark properties of ES cells, and help researchers with the rich source of information to better understand some of the unique features — such as self - renewal and pluripotency — of human embryonic stem cells,» said Ng Huck Hui, Ph.D., senior group leader at GIS and a member of the Singapore team that conducted this research.
To further investigate additional similarities between hNSCs and hESCs at the transcriptional level, we analyzed the expression of key genes involved in hESC self - renewal and pluripotency utilizing semi-quantitative RT - PCR analysis.
TAD dynamics displayed signs of elevated plasticity at later stages of reprogramming, as cells attain pluripotency
Future studies will be aimed at determining the site - specificity for this effect, that is, why the effects are seen specifically at pluripotency genes.
H3K9ac and H3K56ac are enriched at the promoters of genes required to maintain pluripotency, and loss of these epigenetic marks correlates with stem cell differentiation.
At one end of the hierarchy are stem cells expressing most pluripotency genes studied and few lineage specific genes; at the other end are fully committed cells that have extinguished the pluripotency program, and in between there is a continuous spectruAt one end of the hierarchy are stem cells expressing most pluripotency genes studied and few lineage specific genes; at the other end are fully committed cells that have extinguished the pluripotency program, and in between there is a continuous spectruat the other end are fully committed cells that have extinguished the pluripotency program, and in between there is a continuous spectrum.
The lack of co-expression of pluripotency markers and lineage specific markers at the protein level despite robust co-expression of transcripts of both classes of gene suggests a role for post-translational regulation of expression, perhaps by small RNAs.
These observations, which have provided striking insights into the epigenetic regulation of the molecular blueprint for pluripotency within ES cells, have been made at the population level, and thus reflect the summation of activity within all cells in the population.
The present study shows that such a gradient is also seen at the level of single cell analysis, but reveals that there is considerable cell - to - cell variation within this gradient in the expression of pluripotency genes.
Thus, as anticipated from earlier studies, heterogeneity of pluripotency gene expression in single cells is to a degree reflected at the protein level.
Our work indicates that only a small fraction of the population resides at the top of the hierarchy, that lineage priming (co-expression of stem cell and lineage specific genes) characterizes pluripotent stem cell populations, and that extrinsic signaling pathways are upstream of transcription factor networks that control pluripotency.
The HIGH population expressed pluripotency genes at a greater frequency than the other cell populations, and as with the previous analysis, Oct - 4 and DNMT3b were in general more uniformly expressed than were nanog, TDGF - 1 or GDF - 3 (Figure 3a — b).
The 2011 Lasker Lecture, «Induction of Pluripotency by Defined Factors,» was delivered by Shinya Yamanaka to a packed auditorium at the Albert Einstein College of Medicine on October 24, 2011.