Sentences with phrase «pluripotency gene in its genome»

It only covers methods that involve introducing one or more reprogramming genes into an adult cell that has been genetically engineered to carry another pluripotency gene in its genome.

Not exact matches

For example, viruses are ordinarily used to ferry in genes to activate pluripotency, but this foreign DNA integrates into the genome, and experts worry that it might disrupt development or cause cancer.

We interfere with histone modification marks in vivo, both genome - wide (mutant analysis) and gene - specifically (local disruption of chromatin structure), and analyze the effect on transcription and pluripotency.

Furthermore, genome - wide studies, combining chromatin immunoprecipitation (ChIP) and array hybridization (ChIP - on - chip), have revealed that both active and silenced genes are directly bound in ES cells by one or more of the core pluripotency factors Oct4, Sox2 and Nanog [17], [19], [63].