Sentences with phrase «pluripotency of embryonic stem cells»

While the potential of adult stem cells has been understood for some time, researchers have argued that the pluripotency of embryonic stem cells — their ability to be transformed into most if not all of the various cell types of the body — make them more valuable both for research and potentially someday for treatment.

Not exact matches

«Human embryonic stem cells remain the gold standard for pluripotency,» Francis Collins, director of the National Institutes of Health, said at the hearing.

Whitehead Institute researchers have determined that the transcription factor Nanog, which plays a critical role in the self - renewal of embryonic stem cells, is expressed in a manner similar to other pluripotency markers.

This gene is also known to help human embryonic stem cells stay flexible enough to become any type of body cell, a property known as pluripotency.

Pluripotency distinguishes embryonic stem cells from adult stem cells found in adults; while embryonic stem cells can generate all cell types in the body, adult stem cells are multipotent and can produce only a limited number of cell types.

Two papers claiming that stressing the body's cell could produce embryonic - like stem cells, a process called stimulus - triggered acquisition of pluripotency (STAP), were heralded when published in Nature in January but thrashed soon after when problematic images and figures were soon found.

Mouse embryonic stem cells stained for key pluripotency markersGRAZIANO MARTELLO Combining computer science algorithms with biological data has enabled researchers to create a model of the minimal number of factors necessary for mouse embryonic stem cells (ESCs) to self - renew in culture.

Yamanaka and Takahashi began their search by studying embryonic stem cells in the hope of identifying the genes that underlie essential stem cell characteristics, such as pluripotency and proliferation, a cell's ability to replicate itself.

A whole network of these proteins is involved in giving embryonic stem (ES) cells pluripotency — the ability to generate all the cell lineages of the body.

Debojyoti Chakraborty (Buchholz, TUD)-- «Systematic dissection of long non coding RNAs involved in the regulation of embryonic stem cell pluripotency» (2014)

Loss of pluripotency in human embryonic stem cells directly correlates with an increase in nuclear zinc.

Title: Inhibition of glycogen synthase kinase - 3 alleviates Tcf3 repression of the pluripotency network and increases embryonic stem cell resistance to differentiation Authors: Wray J, Kalkan T, Gomez - Lopez S, Eckardt D, Cook A, Kemler R & Smith A Date: 19th June 2011 Publication Details: Nature Cell Biology 13,838 — 845 (2011) doi: 10.1038 / ncbcell resistance to differentiation Authors: Wray J, Kalkan T, Gomez - Lopez S, Eckardt D, Cook A, Kemler R & Smith A Date: 19th June 2011 Publication Details: Nature Cell Biology 13,838 — 845 (2011) doi: 10.1038 / ncbCell Biology 13,838 — 845 (2011) doi: 10.1038 / ncb2267

New research at the Hebrew University of Jerusalem sheds light on pluripotency — the ability of embryonic stem cells to renew themselves...

«The current extension of induced pluripotency to human cells is a major development and although it is early days for this technique it may well prove to be every bit as signifcant as the first derivation of human embryonic stem cells nine years ago.

A human embryonic stem cell is reined in — prevented from giving up its unique characteristics of self - renewal and pluripotency — by the presence of a protein modification that stifles any genes that would prematurely instruct the cell to develop into heart or other specialized tissue.

iPSCs are cells that were originally from adult tissues, but have been forced to produce proteins that are thought to be essential for the pluripotency of human embryonic stem cells.

Title: Nanog Variability and Pluripotency Regulation of Embryonic Stem Cells - Insights from a Mathematical Model Analysis Authors: Glauche I, Herberg M, Roeder I Date: June 2010 Publication Details: PLoS ONE 5 (6): e11238

But the eyebrow - raising reports claimed that adult stem cells sometimes behave like their embryonic counterparts, mimicking their trademark capacity to engender all types of cells — an ability dubbed pluripotency.

Studies in cultured embryonic stem (ES) cells, and our analysis of zebrafish embryos have revealed that pluripotency is characterized by a unique chromatin signature.

«This discovery will advance our understanding of stem cell epigenetics and chromatin structures, provide potential mechanisms on maintaining the hallmark properties of ES cells, and help researchers with the rich source of information to better understand some of the unique features — such as self - renewal and pluripotency — of human embryonic stem cells,» said Ng Huck Hui, Ph.D., senior group leader at GIS and a member of the Singapore team that conducted this research.

Further, we demonstrate that deletion of Alkbh1 in embryonic stem cells leads to upregulation of the core genes involved in pluripotency and that ALKBH1 is required during early differentiation.

Topics covered include embryonic stem cells, pluripotency, germline stem cells, tissue - specific stem cells, stem cell differentiation, epigenetics, stem cell genomics and systems biology, genome reprogramming, cancer stem cells, stem cell niches, stem - cell - based disease models, nuclear transfer technology, bioengineering, drug discovery, in vivo imaging of stem cells, therapeutic applications, regenerative medicine, clinical and translational insights, stem cell research policies, ethical issues, and technical or resource - based innovations.

He seeks to understand the molecular mechanisms that underlie pluripotency and the rapid proliferation of embryonic stem cells — they can become any type of cell in the body — and to identify the factors that induce reprogramming.

Embryonic stem cells derived from human blastocysts have the key advantage of pluripotency, meaning that they form nearly all cell types but also have the disadvantage of forming tumors in vivo, which may limit clinical application to tissue engineering rather than cell transplantation.

Writing in the journal Cell Stem Cell, the team reports that more than half of mouse epiblast stem cells treated with the drug reversed course within three days, and regained an embryonic «be anything» state, also called pluripoteStem Cell, the team reports that more than half of mouse epiblast stem cells treated with the drug reversed course within three days, and regained an embryonic «be anything» state, also called pluripotestem cells treated with the drug reversed course within three days, and regained an embryonic «be anything» state, also called pluripotency.

Correlation of expression and methylation of imprinted genes with pluripotency of parthenogenetic embryonic stem cells

Screening the mammalian extracellular proteome for regulators of embryonic human stem cell pluripotency.

Citation: Hough SR, Laslett AL, Grimmond SB, Kolle G, Pera MF (2009) A Continuum of Cell States Spans Pluripotency and Lineage Commitment in Human Embryonic Stem Cells.

An important concept in this research is pluripotency ---- the ability of the human embryonic stem cell to differentiate or become almost any cell in the body, explained senior author Kenneth S. Kosik, professor in the Department of Molecular, Cellular & Developmental Biology (MCDB).

Currently, stem cell research focuses on renewal and differentiation of stem cells and the molecular mechanisms of its pluripotency - or their ability to develop into any type of cell - using human embryonic stem cells, induced pluripotent stem cells, and stem cells in simpler organisms.

Execution of pluripotency requires progression from the naïve status represented by mouse embryonic stem cells (ESCs) to a state capacitated for lineage specification.

Studies have identified transcription factors such as Stat3, Nanog, and Oct4 as being necessary for embryonic stem (ES) cell self - renewal and maintenance of pluripotency.