Sentences with phrase «pluripotent cells form»

EFTF - expressing pluripotent cells form functional retinal cells and eyes when transplanted to the developing embryo, but can these induced retinal cells also differentiate into all the functional retinal cell classes in a mature normal or damaged retinal environment?

Similarly, EFTF - expressing pluripotent cells formed ectopic eye - like structures when transplanted to the embryonic flank.

In contrast, EFTF - expressing pluripotent cells formed YFP - expressing, pigmented spheroids in 23 % of transplants (N = 566).

Not exact matches

The embryos, which were genetically modified to prevent them from growing their own pancreases, were injected with mouse pluripotent stem cells that formed into a pancreas.

OAR proponents claim that when the altered donor - cell nucleus with its activated nanog gene is transferred to the enucleated oocyte (egg cell), the presence of nanog will immediately convert the enucleated egg cell to a pluripotent cell, without ever forming a zygote.

Experiments in animal cells have shown that although these genes are required to form pluripotent stem cells during development, they are not powerful enough on their own to overcome the epigenetic programming of a mature cell and convert it to a pluripotent stem cell directly.

Because such cells are derived from adult cells, not pluripotent cells — which have the potential to form a kind of tumour called a teratoma — they might be safer than iPS cells.

Last year Loring transformed skin cells from the drill, a silver - bearded African monkey, into a pluripotent stem cell that can form many different tissue types.

They then tried to reprogram skin cells from the animals, turning them into induced pluripotent stem cells (iPS), which are capable of forming other types of cell.

Methods for making bits of brainlike tissue tap the innate tendency of human pluripotent stem cells to form neural tissue.

During embryonic development, organ - specific cell types are formed from pluripotent stem cells, which can differentiate into all cell types of the human body.

By contrast, most embryonic and induced pluripotent stem cells are more restricted in their developmental potential, able to form embryonic cell types, but not extra-embryonic tissues.

Pursuing another strategy, scientists at San Diego Zoo in California last year showed that banked tissue from the almost extinct northern white rhino (Ceratotherium simum cottoni) could be induced to form a line of pluripotent stem cells, capable of forming many tissues.

Researchers at the Salk Institute for Biological Studies have, for the first time, taken chimpanzee and bonobo skin cells and turned them into induced pluripotent stem cells (iPSCs), a type of cell that has the ability to form any other cell or tissue in the body.

Pluripotent cells can become any of the cell types usually found in the body — although there are certain special types of tissue, such as placenta, that they can't form.

A UW — Madison research group has converted skin cells from people and monkeys into a cell that can form a wide variety of nervous - system cells — without passing through the do - it - all stage called the induced pluripotent stem cell, or iPSC.

To form axon fascicles, the research teams manufactured a microdevice in which human neurons derived from induced pluripotent stem cells were injected.

They then used the so - called induced pluripotent stem cells (IPS cells) to reverse a mouse version of the genetic disorder sickle - cell anemia, which causes normally circular red blood cells to form sickle - shaped, thereby impeding blood flow.

Such cells are pluripotent, able to become many cell types as they multiply and differentiate to form tissues.

This shows hair shafts (arrows) formed by induced pluripotent stem cell - derived epithelial stem cells.

The overall aim of this study was to determine if pluripotent cells overexpressing these transcription factors could be intentionally driven toward retinal progenitors that differentiate into multiple retinal cell classes and form a functional retina.

We asked if pluripotent cells could be directed to generate all the retinal cell types necessary to form a functional eye in the frog, Xenopus laevis.

If left untreated, transplanted pluripotent cells only form the epidermal layer of the skin.

Transplanted control pluripotent cells isolated from Venus YFP embryos formed only sheets of epidermis (number of animals or eyes [N] = 108; unpublished data).

It is interesting that YFP - expressing pluripotent cells were rarely detected in the lens, yet often present in the cornea since the surface ectoderm forms both the lens and the cornea.

Dr. Rossi has shown that with the expression of RAD52, a protein not usually expressed in HDR, and dn53BP1, an altered form of 53PB1 (regularly found in the NHEJ pathway), he was able to enable efficient HDR at multiple points of the genome in patient - derived induced pluripotent stem cells.

While both eye fields and EFTF - expressing pluripotent cells generated epidermis, forebrain, and olfactory tissue when grafted to the anterior neural plate, transplanted eye fields also formed muscle and head mesenchyme (Figure 4 and unpublished data).

Despite the remarkable ability of EFTF - expressing pluripotent cells to form eye - like structures on the tadpole flank, it was not possible to record ERGs because of the small size of the induced flank eyes (flank eye volume: 0.007 ± 0.003 mm3; control eye volume: 0.021 ± 0.002 mm3, at stage 41, N = 5).

Interestingly, in addition to the tissues formed by EFTF - expressing pluripotent cells, transplanted eye fields also formed muscle and head mesenchyme (Figure 4J and unpublished data).

When cultured in isolation, pluripotent cells isolated from blastula stage embryos autonomously form epidermis, loosing competence to form other structures.

(D) Pluripotent cells from YFP transgenics form eyes when treated with Noggin protein and grafted to the eye field of stage 15 wild - type hosts (these stage 32 animals were photographed 1 d posttransplant).

These results suggest the fate of pluripotent cells may be purposely altered to generate multipotent retinal progenitor cells, which differentiate into functional retinal cell classes and form a neural circuitry sufficient for vision.

EFTF - expressing pluripotent cells differentiate as retinal cells and incorporate seamlessly with host cells to form mosaic retinas.

(A) Control, pluripotent cells (green) never formed retinal tissue.

Patent explosion Meanwhile, science is rapidly advancing in the field of creating induced pluripotent cells, which like human embryonic stem cells can be manipulated to form other cells.

(A — C) Control YFP - expressing pluripotent cells (YFP) form only epidermis when grafted to embryos after removal of the endogenous (left) eye field.

YFP - only pluripotent cells never formed eyes (unpublished data, N = 31).

So if this is all it takes to reset a cell into a pluripotent form, then it's hard to imagine how the body keeps its cells in line, Egli says.

Under normal conditions, pluripotent frog cells form only skin tissue.

Human - Induced pluripotent stem cells form functional neurons and improve recovery after grafting in stroke - damaged brain.

Embryoid bodies (EB) are the three - dimensional aggregates formed in suspension by pluripotent stem cells (PSC), including embryonic stem cells (ESC) and induced pluripotent stem cells (iPSC).

Tube - forming ability of purified CD31 + endothelial cells derived from induced pluripotent stem cells after VEGF treatment.

Researchers at Boston Children's Hospital have, for the first time, generated blood - forming stem cells in the lab using pluripotent stem cells, which can make virtually every cell type in the body.

In addition, three California - based ALS research labs have joined forces to form the Neuro Collaborative, which will create induced pluripotent stem (iPS) cell lines from ALS patients that can be used to screen for new drugs and will be shared with the other groups.

In this vein, the CASMI Translational Stem Cell Consortium (CTSCC) was formed to unite global thought - leaders, producing academically rigorous and commercially practicable solutions to a range of challenges in pluripotent stem cell translatCell Consortium (CTSCC) was formed to unite global thought - leaders, producing academically rigorous and commercially practicable solutions to a range of challenges in pluripotent stem cell translatcell translation.

Researchers are now able to use induced pluripotent stem cells (iPSC) to form a model of human adult - like cardiac muscle by introducing electric and mechanical stimulation at an early stage.