Sentences with phrase «pluripotent human stem»

Scientists and ethicists are taking a closer look at ways to create pluripotent human stem cells without involving embryos.

Not exact matches

A research group at Cincinnati Children's Hospital Medical Center used human pluripotent stem cells (hPSCs) to grow human stomach tissue (paywall)-- and, notably, the part of the organ that produces digestive enzymes.

A few weeks ago we all heard the announcement of a major scientific breakthrough that allowed scientists to create the equivalent of human embryonic stem cells (called induced pluripotent stem cells) but without using or destroying embryos.

Proponents of human cloning assert that this is the only method of producing pluripotent stem cells with the same genetic make - up as adult patients.

The ANT - OAR proposal represent a scientifically and morally sound means of obtaining human pluripotent stem cells that does not compromise either the science or the deeply held moral convictions of those who oppose the destructive use of human embryos for research» which is a creative approach that can be embraced by both the anything - goes camp and the nothing - goes.

We referred to the news that these cells, called induced pluripotent stem cells (iPSCs), could be made from human skin....

To make the HSCs, the Harvard group used human skin cells to create induced pluripotent stem cells (iPSCs), adult cells researchers genetically reprogram to an embryonic - stem - cell state, where they can grow into any kind of cell.

Induced pluripotent stem cells (known as iPSCs) are similar to human embryonic stem cells in that both cell types have the unique ability to self - renew and have the flexibility to become any cell in the human body.

Anand and his colleague Susan McKay started with human skin cells, which they turned into induced pluripotent stem cells (iPSCs) using a tried - and - tested method.

«Today's findings exemplify the many advances we've made in using CRISPR - Cas9 and human induced pluripotent stem cell technologies and the amazing discoveries that have resulted,» said Hideyuki Okano, MD, PhD, of the Keio University School of Medicine in Tokyo, Japan.

Previous research shows human induced pluripotent stem cells (hiPSCs)-- generated directly from adult cells — can express markers for a wide variety of cells, including those that secrete NP.

Varghese and her team showed that they could control the differentiation of human pluripotent stem cells into functional osteoblasts — bone - building cells — simply by adding the molecule adenosine to their growth medium.

Wells's team first turned human skin cells into pluripotent stem cells, which can grow into any type of tissue.

Scientists headed by Dr. Stevens Rehen differentiated human induced pluripotent stem (iPS) cells into neural stem cells and into further complex tridimensional structures, known as neurospheres and brain organoids.

Researchers at the University of California San Diego have discovered an easy and efficient way to coax human pluripotent stem cells to regenerate bone tissue — by feeding them adenosine, a naturally occurring molecule in the body.

Geron, the biotech wunderkind, last made big news in November 1998 when scientists they funded — James A. Thomson of the University of Wisconsin and John D. Gearhart of Johns Hopkins — independently isolated two sorts of so - called human pluripotent stem cells.

The researchers reprogrammed the cells to create induced pluripotent stem cells in an FDA - compliant facility at the Broad Stem Cell Research Center; the use of this facility is an important step in the process as preclinical research moves toward human clinical tristem cells in an FDA - compliant facility at the Broad Stem Cell Research Center; the use of this facility is an important step in the process as preclinical research moves toward human clinical triStem Cell Research Center; the use of this facility is an important step in the process as preclinical research moves toward human clinical trials.

We don't need to use a cocktail of small molecules, growth factors or other supplements to create a population of bone cells from human pluripotent stem cells like induced pluripotent stem cells,» Varghese said.

Investigators at Johns Hopkins report they have developed human induced - pluripotent stem cells (iPSCs) capable of repairing damaged retinal vascular tissue in mice.

The new method, described in the journal Stem Cells Translational Medicine, could be used to generate large numbers of muscle cells and muscle progenitors directly from human pluripotent stem ceStem Cells Translational Medicine, could be used to generate large numbers of muscle cells and muscle progenitors directly from human pluripotent stem cestem cells.

The human version of the cells, called region - selective pluripotent stem cells, or rsPSCs, can also grow inside a mouse, something other human stem cells can't do, says Jun Wu, a research associate involved in the work, published in May in Nature.

First produced only in the past decade, human induced pluripotent stem cells (iPSCs) are capable of developing into many or even all human cell types.

«It's taken years of trial and error, making educated guesses and taking baby steps to finally produce functioning human muscle from pluripotent stem cells,» said Lingjun Rao, a postdoctoral researcher in Bursac's laboratory and first author of the study.

«New gene editing technique turns human pluripotent stem cells into a model system for polycystic kidney disease.»

Now comes a first rate example of how CRISPR is changing the pace of biomedical research by linking up with another cutting edge technology — human pluripotent stem cells (hPSCs).

In the new study, the researchers instead started with human induced pluripotent stem cells.

The new epidermis, grown from human pluripotent stem cells, offers a cost - effective alternative lab model for testing drugs and cosmetics, and could also help to develop new therapies for rare and common skin disorders.

In fact, recent breakthroughs in the creation of human induced pluripotent stem cells (IPS) and the engineering of biodegradable scaffolds to create tissues may ultimately be applicable to most health conditions known to humankind.

The results obtained by Afsaneh Gaillard's team and that Pierre Vanderhaeghen at the Institute of Interdisciplinary Research in Human and Molecular Biology show, for the first time, using mice, that pluripotent stem cells differentiated into cortical neurons make it possible to reestablish damaged adult cortical circuits, both neuroanatomically and functionally.

In a paper published online yesterday in Stem Cells, the researchers report that they succeeded in generating pluripotent human ES cell lines — i.e., cells that can develop into many different kinds of cells — from one of the 13 late - arrested embryos.

The recipe, described in Nature, allows human pluripotent stem cells to spontaneously attempt to assemble into a tiny approximation of a whole brain by making whatever brain structures the stem cells choose.

Methods for making bits of brainlike tissue tap the innate tendency of human pluripotent stem cells to form neural tissue.

«Scientists turn human induced pluripotent stem cells into lung cells: «Bronchospheres» may pave way for personalized cystic fibrosis treatments.»

The A. Alfred Taubman Medical Research Institute at the U-M Medical School also supported the work, which was reviewed and approved by the U-M Human Pluripotent Stem Cell Research Oversight committee and Institutional Review Board.

«The challenge for the coming decade is to expand on multi-disciplinary and multi-sector collaboration aimed at large - scale production of high - quality human pluripotent stem cells, and also, robust and reliable production of high - quality differentiated cells,» said Professor Norio Nakatsuji, Founding Director of Kyoto University, iCeMS.

Attrition of novel drug candidates due to cardiovascular liabilities (including proarrhythmic risk due to delayed ventricular repolarization and Torsades - de-Pointes arrhythmia) remains a hurdle for drug discovery efforts, a hurdle which may be mitigated by the use of human induced pluripotent stem - cell derived (hiPSC)- cardiomyocytes.

These stem cells — known as induced pluripotent stem cells or iPS cells — can be turned into almost any specialised cell type of the human body, including the cells we need to see.

Finally, they demonstrated that zebrafish OPCs differentiate into mature oligodendrocytes when cultured together with human motor neurons, differentiated from induced pluripotent stem cells.

Alternative cell lines, such as induced pluripotent stem cells generated from patient skin cells, offer a more accurate window on human biology, he says.

This latest study reports the generation of multiple cell lineages of the eye, including the lens, cornea, and conjunctiva, using human induced pluripotent stem cells.

The remaining 114 were listed on the NIH registry of human pluripotent stem cells.

«The spectrum of tissues at risk for transformation when harboring a p53 mutation include many of those that we would like to target for repair with regenerative medicine using human pluripotent stem cells,» said Eggan.

Opponents have argued that the law should be rescinded since embryonic stem cells can now be generated from induced pluripotent stem cells, a technique that does not involve human embryos.

The group focused its efforts on human pluripotent stem cells, which can become all of the body's tissues.

In a published study, the team of researchers implanted human pluripotent stem cells in a special line of pigs developed by Randall Prather, an MU Curators Professor of reproductive physiology.

The study carried out at the University of Eastern Finland used the induced pluripotent stem cell technology, which enables the generation of pluripotent stem cells from human skin fibroblasts.

While stem cells — cells that have the potential to differentiate into other types of cells — exist in adult humans, the most useful stem cells are those found in embryos, which are pluripotent, capable of becoming nearly any cell in the body.

«However, our work illustrates the promise of human pluripotent stem cells as it presents a direct path toward realizing the promise of regenerative medicine for certain hormonal disorders.»

In addition to Loring, Boland and Nazor, authors of the study, «Molecular analyses of neurogenic defects in a human pluripotent stem cell model of Fragile X syndrome,» were Ha T. Tran, Candace L. Lynch and Pietro Paolo Sanna of TSRI; Attila Szücs of the University of California, San Diego, and Eötvös Loránd University; Ryder Paredes of California State University, Channel Islands; and Flora Tassone of the University of California, Davis.

The researchers were also able to control the relative composition of different hormonal cell types simply by exposing human pluripotent stem cells to different ratios of two proteins: fibroblast growth factor 8 and bone morphogenetic protein 2.