Not exact matches
Thanks to crucial contributions from three young
lab members, he said, his team succeeded
in converting mature skin
cells into
pluripotent stem cells.
O'Shea, a professor
in the Department of
Cell & Developmental Biology and director of the U-M
Pluripotent Stem Cell Research
Lab, and McInnis, the Upjohn Woodworth Professor of Bipolar Disorder and Depression
in the Department of Psychiatry, are co-senior authors of the new paper.
Some basic research findings are being translated into new treatments, and with the discovery of induced
pluripotent stem cells in 2006, the field has seen a step - change
in biological understanding that will affect the way new drugs are identified and tested and, potentially, the way
cells can be generated
in the
lab.
Scientists
in the
lab have successfully generated neural
stem cells (NCS) from human embryonic
stem cells and human induced
pluripotent stem cells (these are
stem cells that have been reprogrammed from adult
cells).
Embryonic
stem cells — the subject of so much controversy (witness the new ruling blocking their use)-- were first cultured
in the
lab a little more than a decade ago;
in 2006, there was another breakthrough when adult
cells were coaxed into becoming induced
pluripotent stem cells.
Some researchers are using induced
pluripotent stem (iPS)
cells — tissue - specific
cells (usually skin
cells, but sometimes other tissue
cells) that are reprogrammed
in the
lab to behave like embryonic
stem cells — to grow rods and cones or RPE
cells.
In the
lab, she coaxed skin
cells into becoming induced
pluripotent stem cells, or iPS
cells.
There he worked
in the Kaplan
lab, originally with the Neural Group working to create a scaffold for a model of a three - dimensional interconnected neuronal network grown from human induced
pluripotent stem cells.
Researchers at Boston Children's Hospital have, for the first time, generated blood - forming
stem cells in the
lab using
pluripotent stem cells, which can make virtually every
cell type
in the body.
Neural
stem cells are found
in adult or fetal brain and spinal cord or derived from embryonic
stem cells, which have the capacity to become any
cell type
in the body, or induced
pluripotent stem (iPS)
cells, tissue - specific
cells that are reprogrammed
in the
lab to behave like embryonic
stem cells.
In addition, three California - based ALS research
labs have joined forces to form the Neuro Collaborative, which will create induced
pluripotent stem (iPS)
cell lines from ALS patients that can be used to screen for new drugs and will be shared with the other groups.