Sentences with phrase «pluripotent stem cells using»

Review of «Efficient Generation of Megakaryocytes From Human Induced Pluripotent Stem Cells Using Food and Drug Administration - Approved Pharmacological Reagents» from Stem Cells TM by Stuart P. Atkinson

Efficient generation of megakaryocytes from human induced pluripotent stem cells using food and drug administration - approved pharmacological reagents.

«The induced pluripotent stem cells we used in this study proved to be extremely useful in disease modelling, and they could offer an excellent platform for drug discovery and testing new therapeutic targets for Alzheimer's disease in the future,» says Early Stage Researcher Minna Oksanen, the lead author of the study.

«Induced pluripotent stem cells used to show statin effects on diseased bone.»

Not exact matches

A research group at Cincinnati Children's Hospital Medical Center used human pluripotent stem cells (hPSCs) to grow human stomach tissue (paywall)-- and, notably, the part of the organ that produces digestive enzymes.

Using the gene - editing tool CRISPR - Cas9 to turn off certain genes in a mouse zygote as well as other new techniques to enrich the pluripotent stem cells of a rat, the group managed to grow various rat organs (a pancreas, heart, and eyes) in a mouse embryo.

A few weeks ago we all heard the announcement of a major scientific breakthrough that allowed scientists to create the equivalent of human embryonic stem cells (called induced pluripotent stem cells) but without using or destroying embryos.

The ANT - OAR proposal represent a scientifically and morally sound means of obtaining human pluripotent stem cells that does not compromise either the science or the deeply held moral convictions of those who oppose the destructive use of human embryos for research» which is a creative approach that can be embraced by both the anything - goes camp and the nothing - goes.

To make the HSCs, the Harvard group used human skin cells to create induced pluripotent stem cells (iPSCs), adult cells researchers genetically reprogram to an embryonic - stem - cell state, where they can grow into any kind of cell.

The Muotri lab uses induced pluripotent stem cells from patients with autism and schizophrenia to look for biomarkers of these conditions.

The team then used murine pluripotent stem cells to regenerate thyroid function in a murine model of hypothyroidism.

Anand and his colleague Susan McKay started with human skin cells, which they turned into induced pluripotent stem cells (iPSCs) using a tried - and - tested method.

«Today's findings exemplify the many advances we've made in using CRISPR - Cas9 and human induced pluripotent stem cell technologies and the amazing discoveries that have resulted,» said Hideyuki Okano, MD, PhD, of the Keio University School of Medicine in Tokyo, Japan.

The neural progenitor cells used were derived from iPSCs (induced pluripotent stem cells), which were in turn derived from donor skin cells.

Among the many approaches they took, the researchers generated induced pluripotent stem cells (iPSCs) from the SCARB1 - deficient person, used them to create liver cells, and showed these new cells had profound reduction in their ability to take up HDL.

IBMT worked together with the Fraunhofer Institute for Molecular Biology and Applied Ecology IME, which used pluripotent stem cells to develop a model for investigating cardiotoxicity.

The researchers reprogrammed the cells to create induced pluripotent stem cells in an FDA - compliant facility at the Broad Stem Cell Research Center; the use of this facility is an important step in the process as preclinical research moves toward human clinical tristem cells in an FDA - compliant facility at the Broad Stem Cell Research Center; the use of this facility is an important step in the process as preclinical research moves toward human clinical triStem Cell Research Center; the use of this facility is an important step in the process as preclinical research moves toward human clinical trials.

We don't need to use a cocktail of small molecules, growth factors or other supplements to create a population of bone cells from human pluripotent stem cells like induced pluripotent stem cells,» Varghese said.

The new method, described in the journal Stem Cells Translational Medicine, could be used to generate large numbers of muscle cells and muscle progenitors directly from human pluripotent stem ceStem Cells Translational Medicine, could be used to generate large numbers of muscle cells and muscle progenitors directly from human pluripotent stem cCells Translational Medicine, could be used to generate large numbers of muscle cells and muscle progenitors directly from human pluripotent stem ccells and muscle progenitors directly from human pluripotent stem cestem cellscells.

That message, delivered in two studies published today, is both good news and bad news for researchers who hope to use so - called induced pluripotent stem cells (iPS cells) to study diseases and perhaps some day treat patients.

The results obtained by Afsaneh Gaillard's team and that Pierre Vanderhaeghen at the Institute of Interdisciplinary Research in Human and Molecular Biology show, for the first time, using mice, that pluripotent stem cells differentiated into cortical neurons make it possible to reestablish damaged adult cortical circuits, both neuroanatomically and functionally.

«Inflammation is associated with bone growth: A study using induced pluripotent stem cells suggests that a molecule for inflammation could be a good drug target to prevent diseased bone growth.»

The team used a type of stem cell called induced pluripotent stem cells, or iPSCs.

But more importantly, the research, using induced pluripotent stem cells, suggests the neuronal damage might be reversible through novel anti-inflammatory therapies.

This ball of cells contains «pluripotent stem cells» — blank slates that can be programed into any type of cell in the body — and researchers are hoping to use these stem cells to treat various conditions, including infertility.

Jun Takahashi at Kyoto University, Japan, and colleagues wondered whether they could treat monkeys with a disease like Parkinson's using induced pluripotent stem cells, which are made by coaxing blood or skin cells into becoming stem cells.

A therapeutic screening center, headed by Lee Rubin at the Harvard Department of Stem Cell and Regenerative Biology, is dedicated to using induced pluripotent stem cells to find new drugs for genetic diseaStem Cell and Regenerative Biology, is dedicated to using induced pluripotent stem cells to find new drugs for genetic diseastem cells to find new drugs for genetic diseases.

«It is amazing that we can use urine samples to generate pluripotent stem cells that are directly related to the donor.

Attrition of novel drug candidates due to cardiovascular liabilities (including proarrhythmic risk due to delayed ventricular repolarization and Torsades - de-Pointes arrhythmia) remains a hurdle for drug discovery efforts, a hurdle which may be mitigated by the use of human induced pluripotent stem - cell derived (hiPSC)- cardiomyocytes.

Young - Pearse and colleagues believe that their strategy of using induced pluripotent stem cells to reprogram patient skin cells into neurons of interest could be used to predict which therapeutics will best help early onset Alzheimer's patients.

For the past six years, the Wu laboratory has been investigating how to use immunosuppressive medications to dampen the body's response to both embryonic and induced pluripotent stem cells to render them more amenable for clinical use.

«Use of induced pluripotent stem cell (iPSC) technology» — which involves taking skin cells from patients and reprogramming them into embryonic - like stem cells capable of turning into other specific cell types relevant for studying a particular disease — «makes it possible to model dementias that affect people later in life,» says senior study author Catherine Verfaillie of KU Leuven.

In recent years, Muotri and colleagues have created in vitro cellular models of autism using reprogrammed induced pluripotent stem cells (iPSC) derived from discarded baby teeth of children with autism, work dubbed the «tooth fairy project.»

We converted mouse skin cells into induced pluripotent stem cells — undifferentiated cells that can be used to generate any tissue in the body.

The scientists collected skin cells from 19 people, aged from birth to 89, and prompted them to turn into brain cells using both the induced pluripotent stem cell technique and the direct conversion approach.

This latest study reports the generation of multiple cell lineages of the eye, including the lens, cornea, and conjunctiva, using human induced pluripotent stem cells.

«The spectrum of tissues at risk for transformation when harboring a p53 mutation include many of those that we would like to target for repair with regenerative medicine using human pluripotent stem cells,» said Eggan.

In fact, in an ongoing clinical trial that is transplanting cells derived from induced pluripotent stem cells (iPSCs), gene sequencing is used to ensure the transplanted cell products are free of dangerous mutations.

When the induced pluripotent stem cell method was used, as expected, the patterns in the neurons were indistinguishable between young and old derived samples.

The study carried out at the University of Eastern Finland used the induced pluripotent stem cell technology, which enables the generation of pluripotent stem cells from human skin fibroblasts.

Labs use induced pluripotent stem cells, also known as master cells, which using biochemical cues can be «programmed» to become any type of cell, whether for the heart muscle or otherwise.

«This type of analysis is likely to become a gold standard for quality controlling stem cells, including induced pluripotent stem cells, whether they are to be used solely in research or envisioned for clinical applications,» he says.

This experiment simulated the reprogramming of a patient's adult cells into induced pluripotent stem cells for further medical use.

Using patient - derived stem cells known as induced pluripotent stem cells (iPSC) to study the genetic lung / liver disease called alpha - 1 antitrypsin (AAT) deficiency, researchers have for the first time created a disease signature that may help explain how abnormal protein leads to liver disease.

The achievement represents a new direction in the use of human pluripotent stem cells, which have the potential to develop into any of the tissues of the human body.

Previously, other groups of scientists have used induced pluripotent stem cells (iPSCs) to make NPC - like cells.

The authors used induced pluripotent stem cells (iPSCs) generated from the fibroblasts of both healthy individuals (WT - iPSC) and TD patients (TD - iPSC).

Other researchers had successfully used a similar process to turn skin cells into embryonic - like cells called induced pluripotent stem cells, and then grow those iPS cells into nerve cells, but Wernig's lab was the first to convert skin cells directly into nerve cells without the intermediate iPS cell step.

UCLA researchers led by Drs. Peiyee Lee and Richard Gatti at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research have used induced pluripotent stem cells (iPSC) to advance disease - in - a-dish modeling of a rare genetic disorder, Ataxia Telangiectasia (AStem Cell Research have used induced pluripotent stem cells (iPSC) to advance disease - in - a-dish modeling of a rare genetic disorder, Ataxia Telangiectasia (Astem cells (iPSC) to advance disease - in - a-dish modeling of a rare genetic disorder, Ataxia Telangiectasia (A-T).

«We used human skin cells that we obtained from patients affected with ALS and converted them into neurons via a technology called induced pluripotent stem cell production,» she explains.