«The induced
pluripotent stem cells we used in this study proved to be extremely useful in disease modelling, and they could offer an excellent platform for drug discovery and testing new therapeutic targets for Alzheimer's disease in the future,» says Early Stage Researcher Minna Oksanen, the lead author of the study.
«Induced
pluripotent stem cells used to show statin effects on diseased bone.»
Efficient generation of megakaryocytes from human induced
pluripotent stem cells using food and drug administration - approved pharmacological reagents.
Review of «Efficient Generation of Megakaryocytes From Human Induced
Pluripotent Stem Cells Using Food and Drug Administration - Approved Pharmacological Reagents» from Stem Cells TM by Stuart P. Atkinson
Not exact matches
A research group at Cincinnati Children's Hospital Medical Center
used human
pluripotent stem cells (hPSCs) to grow human stomach tissue (paywall)-- and, notably, the part of the organ that produces digestive enzymes.
Using the gene - editing tool CRISPR - Cas9 to turn off certain genes in a mouse zygote as well as other new techniques to enrich the
pluripotent stem cells of a rat, the group managed to grow various rat organs (a pancreas, heart, and eyes) in a mouse embryo.
A few weeks ago we all heard the announcement of a major scientific breakthrough that allowed scientists to create the equivalent of human embryonic
stem cells (called induced
pluripotent stem cells) but without
using or destroying embryos.
The ANT - OAR proposal represent a scientifically and morally sound means of obtaining human
pluripotent stem cells that does not compromise either the science or the deeply held moral convictions of those who oppose the destructive
use of human embryos for research» which is a creative approach that can be embraced by both the anything - goes camp and the nothing - goes.
To make the HSCs, the Harvard group
used human skin
cells to create induced
pluripotent stem cells (iPSCs), adult
cells researchers genetically reprogram to an embryonic -
stem -
cell state, where they can grow into any kind of
cell.
The Muotri lab
uses induced
pluripotent stem cells from patients with autism and schizophrenia to look for biomarkers of these conditions.
The team then
used murine
pluripotent stem cells to regenerate thyroid function in a murine model of hypothyroidism.
Anand and his colleague Susan McKay started with human skin
cells, which they turned into induced
pluripotent stem cells (iPSCs)
using a tried - and - tested method.
«Today's findings exemplify the many advances we've made in
using CRISPR - Cas9 and human induced
pluripotent stem cell technologies and the amazing discoveries that have resulted,» said Hideyuki Okano, MD, PhD, of the Keio University School of Medicine in Tokyo, Japan.
The neural progenitor
cells used were derived from iPSCs (induced
pluripotent stem cells), which were in turn derived from donor skin
cells.
Among the many approaches they took, the researchers generated induced
pluripotent stem cells (iPSCs) from the SCARB1 - deficient person,
used them to create liver
cells, and showed these new
cells had profound reduction in their ability to take up HDL.
IBMT worked together with the Fraunhofer Institute for Molecular Biology and Applied Ecology IME, which
used pluripotent stem cells to develop a model for investigating cardiotoxicity.
The researchers reprogrammed the
cells to create induced
pluripotent stem cells in an FDA - compliant facility at the Broad Stem Cell Research Center; the use of this facility is an important step in the process as preclinical research moves toward human clinical tri
stem cells in an FDA - compliant facility at the Broad
Stem Cell Research Center; the use of this facility is an important step in the process as preclinical research moves toward human clinical tri
Stem Cell Research Center; the
use of this facility is an important step in the process as preclinical research moves toward human clinical trials.
We don't need to
use a cocktail of small molecules, growth factors or other supplements to create a population of bone
cells from human
pluripotent stem cells like induced
pluripotent stem cells,» Varghese said.
The new method, described in the journal
Stem Cells Translational Medicine, could be used to generate large numbers of muscle cells and muscle progenitors directly from human pluripotent stem ce
Stem Cells Translational Medicine, could be used to generate large numbers of muscle cells and muscle progenitors directly from human pluripotent stem c
Cells Translational Medicine, could be
used to generate large numbers of muscle
cells and muscle progenitors directly from human pluripotent stem c
cells and muscle progenitors directly from human
pluripotent stem ce
stem cellscells.
That message, delivered in two studies published today, is both good news and bad news for researchers who hope to
use so - called induced
pluripotent stem cells (iPS
cells) to study diseases and perhaps some day treat patients.
The results obtained by Afsaneh Gaillard's team and that Pierre Vanderhaeghen at the Institute of Interdisciplinary Research in Human and Molecular Biology show, for the first time,
using mice, that
pluripotent stem cells differentiated into cortical neurons make it possible to reestablish damaged adult cortical circuits, both neuroanatomically and functionally.
«Inflammation is associated with bone growth: A study
using induced
pluripotent stem cells suggests that a molecule for inflammation could be a good drug target to prevent diseased bone growth.»
The team
used a type of
stem cell called induced
pluripotent stem cells, or iPSCs.
But more importantly, the research,
using induced
pluripotent stem cells, suggests the neuronal damage might be reversible through novel anti-inflammatory therapies.
This ball of
cells contains «
pluripotent stem cells» — blank slates that can be programed into any type of
cell in the body — and researchers are hoping to
use these
stem cells to treat various conditions, including infertility.
Jun Takahashi at Kyoto University, Japan, and colleagues wondered whether they could treat monkeys with a disease like Parkinson's
using induced
pluripotent stem cells, which are made by coaxing blood or skin
cells into becoming
stem cells.
A therapeutic screening center, headed by Lee Rubin at the Harvard Department of
Stem Cell and Regenerative Biology, is dedicated to using induced pluripotent stem cells to find new drugs for genetic disea
Stem Cell and Regenerative Biology, is dedicated to
using induced
pluripotent stem cells to find new drugs for genetic disea
stem cells to find new drugs for genetic diseases.
«It is amazing that we can
use urine samples to generate
pluripotent stem cells that are directly related to the donor.
Attrition of novel drug candidates due to cardiovascular liabilities (including proarrhythmic risk due to delayed ventricular repolarization and Torsades - de-Pointes arrhythmia) remains a hurdle for drug discovery efforts, a hurdle which may be mitigated by the
use of human induced
pluripotent stem -
cell derived (hiPSC)- cardiomyocytes.
Young - Pearse and colleagues believe that their strategy of
using induced
pluripotent stem cells to reprogram patient skin
cells into neurons of interest could be
used to predict which therapeutics will best help early onset Alzheimer's patients.
For the past six years, the Wu laboratory has been investigating how to
use immunosuppressive medications to dampen the body's response to both embryonic and induced
pluripotent stem cells to render them more amenable for clinical
use.
«
Use of induced
pluripotent stem cell (iPSC) technology» — which involves taking skin
cells from patients and reprogramming them into embryonic - like
stem cells capable of turning into other specific
cell types relevant for studying a particular disease — «makes it possible to model dementias that affect people later in life,» says senior study author Catherine Verfaillie of KU Leuven.
In recent years, Muotri and colleagues have created in vitro cellular models of autism
using reprogrammed induced
pluripotent stem cells (iPSC) derived from discarded baby teeth of children with autism, work dubbed the «tooth fairy project.»
We converted mouse skin
cells into induced
pluripotent stem cells — undifferentiated
cells that can be
used to generate any tissue in the body.
The scientists collected skin
cells from 19 people, aged from birth to 89, and prompted them to turn into brain
cells using both the induced
pluripotent stem cell technique and the direct conversion approach.
This latest study reports the generation of multiple
cell lineages of the eye, including the lens, cornea, and conjunctiva,
using human induced
pluripotent stem cells.
«The spectrum of tissues at risk for transformation when harboring a p53 mutation include many of those that we would like to target for repair with regenerative medicine
using human
pluripotent stem cells,» said Eggan.
In fact, in an ongoing clinical trial that is transplanting
cells derived from induced
pluripotent stem cells (iPSCs), gene sequencing is
used to ensure the transplanted
cell products are free of dangerous mutations.
When the induced
pluripotent stem cell method was
used, as expected, the patterns in the neurons were indistinguishable between young and old derived samples.
The study carried out at the University of Eastern Finland
used the induced
pluripotent stem cell technology, which enables the generation of
pluripotent stem cells from human skin fibroblasts.
Labs
use induced
pluripotent stem cells, also known as master
cells, which
using biochemical cues can be «programmed» to become any type of
cell, whether for the heart muscle or otherwise.
«This type of analysis is likely to become a gold standard for quality controlling
stem cells, including induced
pluripotent stem cells, whether they are to be
used solely in research or envisioned for clinical applications,» he says.
This experiment simulated the reprogramming of a patient's adult
cells into induced
pluripotent stem cells for further medical
use.
Using patient - derived
stem cells known as induced
pluripotent stem cells (iPSC) to study the genetic lung / liver disease called alpha - 1 antitrypsin (AAT) deficiency, researchers have for the first time created a disease signature that may help explain how abnormal protein leads to liver disease.
The achievement represents a new direction in the
use of human
pluripotent stem cells, which have the potential to develop into any of the tissues of the human body.
Previously, other groups of scientists have
used induced
pluripotent stem cells (iPSCs) to make NPC - like
cells.
The authors
used induced
pluripotent stem cells (iPSCs) generated from the fibroblasts of both healthy individuals (WT - iPSC) and TD patients (TD - iPSC).
Other researchers had successfully
used a similar process to turn skin
cells into embryonic - like
cells called induced
pluripotent stem cells, and then grow those iPS
cells into nerve
cells, but Wernig's lab was the first to convert skin
cells directly into nerve
cells without the intermediate iPS
cell step.
UCLA researchers led by Drs. Peiyee Lee and Richard Gatti at the Eli and Edythe Broad Center of Regenerative Medicine and
Stem Cell Research have used induced pluripotent stem cells (iPSC) to advance disease - in - a-dish modeling of a rare genetic disorder, Ataxia Telangiectasia (A
Stem Cell Research have
used induced
pluripotent stem cells (iPSC) to advance disease - in - a-dish modeling of a rare genetic disorder, Ataxia Telangiectasia (A
stem cells (iPSC) to advance disease - in - a-dish modeling of a rare genetic disorder, Ataxia Telangiectasia (A-T).
«We
used human skin
cells that we obtained from patients affected with ALS and converted them into neurons via a technology called induced
pluripotent stem cell production,» she explains.