Sentences with phrase «podocyte with»
A team led by Donald Ingber, Professor of Bioengineering at the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS) and Founding Director of Harvard's Wyss Institute of Biologically Inspired Engineering, now reports a solution to this challenge in Nature Biomedical Engineering, which enables the differentiation of human induced pluripotent stem (iPS) cells into mature podocytes with more than 90 percent efficiency.
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Filtration in the glomerulus is performed by cells called «podocytes» that are in direct contact with the blood vessels.
This report of the successful connection of capillaries with the podocytes of iPS cell - manufactured human glomeruli resulting in a distinct filtration membrane is the first of its kind in the world.
The scientists got another surprise when they followed up on this finding with mouse experiments that exposed specialized kidney cells called «podocytes», a key component of the blood filtering, to high levels of glucose.
Now, with the team's newly engineered human kidney glomerulus - on - a-chip, researchers also can get in vitro access to the kidney's core filtration mechanisms that are critical for drug clearance and pharmacokinetics, in addition to studying human podocytes at work.
«The development of a functional human kidney glomerulus chip opens up an entirely new experimental path to investigate kidney biology, carry out highly personalized modeling of kidney diseases and drug toxicities, and the stem cell - derived kidney podocytes we developed could even offer a new injectable cell therapy approach for regenerative medicine in patients with life - threatening glomerulopathies in the future,» said Ingber.
Linking the differentiation process with organ - on - a-chip technology pioneered by his team, the researchers went on to engineer the first in vitro model of the human glomerulus, demonstrating effective and selective filtration of blood proteins and podocyte toxicity induced by a chemotherapy drug in vitro.