Sentences with phrase «point mutations occur»

The rapid pace of morphological evolution noted by Darwin along with Thompson's observations of topological conservation are not easily reconciled with the rates at which point mutations occur or with the sensitivity of complex organisms and their proteins to random point mutations.

However, most point mutations occur at low frequency, and the function of these alleles remains undefined.

Not exact matches

Although the disease appears to be caused by a genetic defect, it doesn't run in families, suggesting that the mutation occurs randomly in egg or sperm cells or at some point after fertilization.

Some critics questioned the mutation rate the authors applied, and others noted that the sharp decline could have occurred eons ago — a point Roman and Palumbi don't dispute.

Verma is quick to point out that although there have been two case studies in which BRCA1 mutations were linked to brain abnormalities, the dramatic effects documented in the mice in the study are unlikely to occur in women with a BRCA1 mutation, who still have some functioning BRCA1, compared with the mice who had none at all.

To develop their approach, the team leveraged known point mutations that occur in bacterial enzymes, providing pathogens with resistance to antibiotics.

Naturally occurring inactivating mutations in genes in humans represents a powerful entry point into this uncharacterized biology.