Sentences with phrase «polydiacetylene side chains»

Moreover, the Cardano technology aims to add features like metadata, side chains, smart contracts, decentralized apps (Dapps), and multi-party computation.

Cardano aims to enable cross chain transfers through side chains, which conduct transactions between two parties off chain.

The Affiliate Economy Token will be a side chain to a widely adopted and scalable blockchain like Bitcoin, Ethereum, Chia or Stellar.

Garzik believes all blockchains, even private chains, must be based on public technology: «And then from side chains, private chains, confederated chain perspective, use that same software and simply build a gate around that permissions who is going to use that system.

A Main Chain and multi-layer Side Chains to handle various commercial scenarios.

The polymer also has two types of side chains for covalent bonding to metals — one for binding to silicon and glass, the other for binding to oxides of what are known as transition metals, which include titanium and iron.

Some of the side chains whose mutation reduce DNA binding form clusters on a surface near the amino terminus.

The third can house a side chain.

The amino acid backbones snap together like beads on a string, the side chains arranged in a particular order for each protein.

And like protein structures, the TZP side chains were arranged in specific positions around the exterior of the rods formed by the backbone - backbone interactions.

Each has the same backbone, from which juts a group of atoms called a side chain that gives the amino acid its particular chemical characteristic.

For this study, they created five different side chains.

Grate needed three things to mimic proteins: raw components with a backbone that can support a large variety of side chains; the ability to put the side chains in a particular order; the stickiness, which chemists refer to as non-covalent bonds.

They made a variety of monomers by adding different side chains to cyanuric chloride, with each monomer a single building block analogous to an amino acid.

Epigenetic factors modify histone tails by e.g. transferring methyl or acetyl groups on lysine side chains.

The next step is to create a larger library of side chains, the count of which is ten so far.

The researchers in Bayreuth also found out that the elongated polymers possess a scaffold formed by its side chains, which stabilizes the elongated structure.

Now, a team led by Zhengzhong Shao of Fudan University in China report that introducing peptide side chains into the polymer gives fibres that are strong and exhibit a remarkably rapid color change even at temperatures up to 200 °C.

Polymers are strings of molecules with a central backbone and may contain side chains called «pendant groups» that dangle from the central structure.

DNA sequence discrimination by CAP derives both from sequence - dependent distortion of the DNA helix and from direct hydrogen - bonding interactions between three protein side chains and the exposed edges of three base pairs in the major groove of the DNA.

They have synthesized a physically cross-linked elastomer composed of a central block onto which side chains are grafted (like a bottle brush) and with linear terminal blocks at each end.

By adjusting the length or density of the «brush's» various side chains, these properties can be modulated.

They found that one of the fragments — a molecule matching the side chain of the full ADEP molecule — increased the efficacy of the ADEP four-fold in killing the bacteria.

Prof. Cho emphasized «We investigated the effects of semi-fluoroalkyl side chains of conjugated polymers at the molecular level and suggested a new strategy to design highly - performing polymeric materials for next - generation plastic electronics.»

The team explained this phenomenon is attributed to the strong self - organization of the side chains and significantly boosts charge transport in polymer semiconductors.

The team modified a n - type conjugated polymer with semi-fluoroalkyl side chains — which are found to have several unique properties, such as hydrophobicity, rigidity, thermal stability, chemical and oxidative resistance, and the ability to self - organize.

In chlorophyll, modification of one of the side chains helps to stabilise the reduced chlorin ring in the presence of oxygen (chlo - rins without such rings are easy to oxidise).

The various alpha amino acids differ in which side chain (R group) is attached to their alpha carbon.

In the new study, the researchers were able to determine that the water molecules directly touched the protein's «side chains,» the portions of the protein molecule that bind and unbind with each other to enable folding and function.

Images produced by the study clearly show the structure of the proteasome complex — with the protein backbone of each of its 28 subunits visible along with most of the side chains of the proteins.

To do so, they added back a small amount of the NOE and RDC data, but just in the parts of the analysis that deduce the shape of the general backbone of the protein rather then the position of all the individual atoms in each amino acid side chain.

They then relied on their ROSETTA software to sort out the position of the atoms in the protein's side chains.

With a few simple alterations to the side chains that branch out from the polymer backbone, the researchers were able to create a shape - shifting version of the hole - punching agent.

However, both the negatively charged side chain of aspartic acid and the positively charged arginine turned out to be knock - out criteria for using the transport system.

In this case, the handholds are the amino acid side chains of a protein that will interact with other proteins or small molecules, and the body is the folding of the protein that incorporates all the amino acids into one structure.

Side chains are essentially small molecules of different shapes, sizes and chemical natures attached to the longer lipid - like peptoids.

Heparan sulfate side chains have a critical role in the inhibitory effects of perlecan on vascular smooth muscle cell response to arterial injury.

The effect of shifting the basic side chain from the N - 1 nitrogen to the C - 4 position of the benzimidazole was investigated.

After further modifications of FC131, including an N - methylation and the introduction of a side chain, aimed at affinity enhancement, compound 32 was selected for a dimerization study.

A number of different domain types interact with histone tails to read, write or erase protein side chain modifications.

Synthesized from a combination of modified versions of the amino acid glycine, the new film is flexible, allows greater control over desired interactions through introduction of specific side chains, and is far more thermally and chemically stable than those assembled from natural polypeptides or lipids.

Chen's group tested the ability of peptoids to do so by introducing a variety of side chains.

These compounds include some features of the polyethylene - hexamethylene biguanide NB325, as well as the peptide T140 that has five guanide groups on the side chains of arginine residues.

One possibility is that decreased levels of BR precursors (e.g., isofucosterol and 24 - methylene cholesterol) resulted from increased catabolism through side chain cleavage.

Interestingly, the unique mass feature identified in our nontargeted assay of bsl1 - 1 inflorescences is consistent with a C21 pregnane that would result from side chain cleavage (Kolbe et al., 1994)(Supplemental Figure 6).

Since two stereocenters were present in the structure, the initially mixture of four stereoisomers was subsequently separated into the single components to evaluate the effects associated with the absolute configuration of the side chains.

SAR studies performed on FC131 analogues, such as modification of the amino acid residues as well as ring structures and backbones, indicated that a defined spatial arrangement of the functional groups on the side chain is necessary for the activity of such compounds.

Further modifications focused on the replacement of the side chain methyl group with several alternative substituents.

Replacement of the side chain with an isopropyl group led to the most potent compound 88, showing an IC50 of 2 nM for antiviral activity and suitable pharmacokinetic properties.

The replacement of the Arg3 - Nal4 peptide bond with an (E)- alkene isostere in compound 7 produced a negative effect on CXCR4 inhibitory activity, probably due to the lack of H - bonding of amide moiety and a different interaction of pseudo -1,3-allylic strain between the Arg3 carbonyl group and the Nal4 side chain.