Sentences with word «polygenic»

Thursday, Oct. 19, 11:30 - 11:45 a.m., Room 320, South Building Platform Presentation: Association of polygenic risk scores for multiple cancers in a phenome - wide study: Results from The Michigan Genomics Initiative L.G. Fritsche, University of Michigan School of Public Health, et al

The influence of polygenic risk for bipolar disorder on neural activation assessed using fMRI

These are known as With polygenic disorders, a number of genes must combine to cross a threshold and produce an affected dog.

For polygenic models, five chains were run per trait, each consisting of 25500 cycles including a burn - in period of 500 cycles.

With polygenic traits a breeder must consider the history of the trait in the family, rather than in the pedigree.

The results suggest that elevated plasma levels of inflammatory biomarkers, including complement proteins, associate with polygenic risk scores in AD, further strengthening the link between genetic and biomarker disease predictors and indicating a potential role for these markers in disease prediction and patient stratification in AD.

It is an inherited polygenic disease in the formation of the elbow.

It may soon be possible to identify the sets of genes responsible for polygenic disorders like hip dysplasia.

Ultimately, these methods can be applied to multiple domesticated and wild species to give us a broader picture of the the specific traits that contribute to adaptation and the overall importance of polygenic adaptation in shaping trait variation.

Education - associated polygenic variation also captured covariation between environmental exposures and children's inattention / hyperactivity, conduct problems, and educational achievement.

Application of Gibbs sampling for inference in a mixed major gene — polygenic inheritance model in animal populations.

Luxating patellas are polygenic threshold traits1, 2.

We investigated covariation between trait - associated polygenic variation identified by genome - wide association studies (GWASs) and specific environmental exposures, controlling for overall genetic relatedness using a genomic relatedness matrix restricted maximum - likelihood model.

Genetic disorders without a known mode of inheritance should be managed in the same way as polygenic disorders.

All this is sort of known (e.g., genetic architecture, causal roles) yet «jump - to - the - genes» GWASing continues (with rickety elaborations like polygenic scoring).

If you are getting a puppy from a breeder who has several generations of heart certifications then you will have more information to go on, but polygenic genes can skip many generations before they appear again, so Cavalier breeders can not guarantee you that a puppy will not develop a heart problem.

Bioinformatics and Genomic Technology: Leader Deanna Church Cancer Genetics: Leader Fergus Couch Cardiovascular and Metabolic Genetics: Leader Ingrid Borecki Clinical Genetics and Dysmorphology: Leader Tony Wynshaw - Boris Complex Traits and Polygenic Disorders: Leader Sekar Kathiresan Evolutionary and Population Genetics: Leader Carlos Bustamante Prenatal, Perinatal, and Reproductive Genetics: Leader Diana Bianchi

Association between polygenic risk scores for attention - deficit hyperactivity disorder and educational and cognitive outcomes in the general population.

«These results suggest a significant polygenic contribution in individuals presenting with EOCAD [early onset coronary artery disease], which could be more prevalent than familial hypercholesterolemia,» the study states.

Antisocial behaviors are complex polygenic phenotypes that are due to a multifactorial arrangement of genetic polymorphisms.

Weeks ago, I asked the teacher about what knowledge base the students would have in genetics, and was impressed to learn that their curriculum included not only Mendel and Punnett squares, but also polygenic traits, sex - linked genes, and genetic engineering.

I show that we can leverage trait - associated loci identified from genome - wide association studies to detect the coordinated shifts in allele frequency expected under polygenic adaptation.

The Microsatellite Center is a high - throughput genotyping laboratory dedicated to mapping monogenic and especially polygenic factors with linkage analysis by using fluorescent detection of microsatellites.

It's most similar to the common polygenic model of disease for T2D, suggesting that this study supports a minor role for rare and low - frequency variants.

Genome - wide association studies (GWAS) have demonstrated a significant polygenic contribution to bipolar disorder (BD) where disease risk is determined by the summation of many alleles of small

In this talk, I describe strategies for detecting polygenic adaptation at the phenotypic and genotypic level.

We construct and analyze a model of a highly polygenic complex disease at evolutionary equilibrium under mutation - selection - drift balance.

Although gene — environment correlation is recognized and investigated by family studies and recently by SNP - heritability studies, the possibility that genetic effects on traits capture environmental risk factors or protective factors has been neglected by polygenic prediction models.

The estimate of polygenic variance from the mixed inheritance models still remained statistically significant for HD in each breed, while, for ED, it stayed significant only in the Rottweiler.

From Wikipedia on polygenics.

If anybody even were to come up with cheap testing of such polygenic traits, this approach is still decades away.

Fifty - four per cent were single gene mutations, and the other 13 per cent were polygenic DNA variants, meaning they were a combination of multiple bad genes inherited together.

They created polygenic risk scores — a «composite» score of genetic effects that forms an index of genetic risk — of ADHD for 8,229 ALSPAC participants.

«It may be the case that at some point polygenic risk scores may, in conjunction with other clinical information, help to identify children who will struggle in school and other demanding contexts due to attention difficulties,» said Dr. John Krystal, Editor of Biological Psychiatry.

Adaptation in quantitative traits likely often occurs through subtle shifts in allele frequencies at many loci, a process called polygenic adaptation.

A decade into the era of well powered and reproducible genome wide association studies, one thing is clear: many complex diseases are extremely polygenic, with thousands or perhaps tens of thousands of segregating variants contributing to variation in risk among individuals.

We show that in fact, so long as the disease is sufficiently polygenic, the selection coefficients of individual loci are insensitive to the fitness cost of the disease, and instead depend on the distribution of effect sizes and the degree of mutational bias toward increased disease liability.

Initially applied to polygenic myocardial infarction and coronary heart disease risks, the methodology can now be applied to a range of high - impact disorders such as schizophrenia, Type 2 diabetes, autism, and cancer.

«Combining polygenic screening with current testing for familial hypercholesterolemia could potentially increase five-fold the number of cases for which a genetic explanation can be found,» he added.

In the study, researchers compared polygenic risk scores between study participants with and without early - onset heart disease.

Limitations of the db / db mouse in translational wound healing research: Is the NONcNZO10 polygenic mouse model superior?

Emerging polygenic models, such as NONcNZO10 / LtJ, exhibit more moderate diabetes phenotypes and have an intact leptin / leptin receptor axis.

«We think it's more polygenic — that is, multiple genes might help increase your risk, rather than just one,» says Dr. Scharre.

Association of Genetic Waist - to - Hip Ratio Adjusted for Body Mass Index With Coronary Heart Disease, Before and After Adjustment for the Mediating Association of Triglycerides, Using the Primary 48 SNP Polygenic Risk Score

Individual Differences in Amygdala - Medial Prefrontal Anatomy Link Negative Affect, Impaired Social Functioning, and Polygenic Depression Risk

One point to note about this type of genetic disorder is that the primary cause, i.e. the «aggravated change in conformation», is usually polygenic, i.e. due to the interaction of several genes.