Hendrickson, L. Davis, C. R. Roach, C. Nguyen, D. K. Aldrich, T. McAda, P. C. and Reeves, C. D. Lovastatin biosynthesis in Aspergillus terreus: characterization of blocked mutants, enzyme activities and a multifunctional
polyketide synthase gene.
Defense: «Effects of canopy cover and pH on
polyketide synthase gene transcription in Cladonie stygia and the polyketides produced in natural conditions.»
Not exact matches
But
polyketide synthases don't work without a co-factor called phosphopantetheine, so the researchers also introduced a
gene from the soil bacterium Bacillus subtilis that encodes the enzyme that attaches phosphopantetheine to the
polyketide synthase.
They first introduced three
genes from a soil bacterium called Saccharopolyspora erythraea, which together produce an enzyme called a
polyketide synthase, which produces one particular
polyketide.