Sentences with phrase «polymorphism analysis»

In the present study, we used a combination of BAC clone contig construction, polymorphism analysis of DNA from congenic strains, and sequence mining of the human orthologous region to generate an integrated map of the Idd10 region on mouse chromosome 3.

Is the Subject Area «Restriction fragment length polymorphism analysis» applicable to this article?

Not exact matches

Analyses were used to assess whether these polymorphisms are associated with embryo quality or with ongoing pregnancy or miscarriage rates.

Their preliminary analysis revealed several mutations known as single nucleotide polymorphisms (SNPs) in the ALR gene, many of which haven't been identified before.

Fully sequenced genomes remain rare, so the bulk of the analysis was done by looking at genetic markers known as single nucleotide polymorphisms or SNPs.

Conventional analyses look for individual mutations called SNPs — single - nucleotide polymorphisms.

Furthermore, the analysis of data on single - nucleotide polymorphisms, the main cause of difference between human beings, allows the prediction of phenotypic effects of a particular genetic variation.

Results from a statistical analysis shows a cluster of SNPs — single nucleotide polymorphisms — in one section of a single gene, indicating the location of a mutation likely linked to autism.

Falling well short of full genome analyses, these services scan an individual's DNA for single nucleotide polymorphisms — point mutations — that are linked to traits and diseases.

In order to find out whether this polymorphism is also associated with extreme longevity, Spanish researchers performed an analysis of the frequencies of this polymorphism among centenarians and healthy adults in two independent cohorts, by geographical regions and by ethnic groups.

Their analysis identified new «extreme longevity - promoting variants» on chromosomes 4 and 7, while also confirming variants (SNPs, or single nucleotide polymorphisms) previously associated with longevity.

The trial has also contributed 1000 blood samples to the UK translational research study RAPPER (Radiogenomics: Assessment of Polymorphisms for Predicting the Effects of Radiotherapy), which aims to ultimately develop individualised radiotherapy plans based on the analysis of individual patients» genetics.

Professor Haase also studies the relevance of genetic polymorphisms of DNA - repair and detoxification genes for AML and MDS, the relevance of iron overload for stem cell functions in MDS, and the establishment of FISH analysis of CD34 + cells from the peripheral blood as a diagnostic tool for screening and monitoring in patients with MDS.

Previous genetic studies have examined the association of aspirin, NSAIDs, or both with colorectal cancer according to a limited number of candidate genes or pathways.6 - 10 Thus, to comprehensively identify common genetic markers that characterize individuals who may obtain differential benefit from aspirin and NSAIDs, we conducted a discovery - based, genome - wide analysis of gene × environment interactions between regular use of aspirin, NSAIDs, or both and single - nucleotide polymorphisms (SNPs) in relation to risk of colorectal cancer.

A genetic score (GS) was calculated on the basis of suggestive single nucleotide... polymorphisms (SNPs) found by association analyses.

Comparative analysis of length polymorphisms in the promoter region of the serotonin transporter gene (SLC6A4) in Cercopithecidae [abstract].

Analysis of a linkage peak on chromosome 13 with a dense set of SNPs (single nucleotide polymorphisms) revealed a four - SNP haplotype spanning the gene encoding FLAP (ALOX5AP) that confers an approximately twofold increased risk of myocardial infarction, or heart attack.

This analysis revealed a statistically significant excess of shared derived polymorphisms between the ancient and domesticated horses in the following quartets (Przewalski's, Domesticated; Ancient, Donkey), where «Domesticated» represents any of the six domesticated horse genomes included in this study (SI Appendix, section S2.7).

The goal of this project is to identify the specific nucleotide sequences and / or single nucleotide polymorphisms that are correlated with expression of virulence and disease via comparative genomic analysis between B. pseudomallei strains as well as between various bacteriophages harbored within B. pseudomallei.

Research Paper The Interaction of Smoking with Gene Polymorphisms on Four Digestive Cancers: A Systematic Review and Meta - Analysis Le Du, Lei Lei, Xiaojuan Zhao, Hongjuan He, Erfei Chen, Jing Dong, Yuan Zeng, Jin Yang J. Cancer 2018; 9 (8): 1506 - 1517.

Many million different users consult these databases each year, seeking information on anything from DNA sequences, protein structures, gene expression profiles, human genetic polymorphism or even comparative analyses of entire genomes.

Allele - specific PCR, molecular cytogenetic studies, microsatellite PCR, Affymetrix single nucleotide polymorphism array analyses, and colony assays were undertaken on subgroups of patients.

Magne Friberg & Bengt Karlsson — 2010 (5)([email protected]) Keywords: diapause, direct development, dispersal, flight performance, nitrogen analysis, phenotypic plasticity, reproductive output, seasonal polymorphism, trade - off

Vitamin D receptor gene polymorphisms, serum 25 - hydroxyvitamin D levels, and melanoma: UK case - control comparisons and a meta - analysis of published VDR data.

Demonstration of loss of heterozygosity by single - nucleotide polymorphism microarray analysis and alterations in strain morphology in Candida albicans strains during infection.

Summary of the analyses of polymorphism and frequency spectrum tests of neutrality in both rabbit subspecies for three different datasets.

This section invites manuscripts describing (a) Linkage, association, substitution or positional mapping and epigenetic studies in any species; (b) Validation studies of candidate genes using genetically - engineered mutant model organisms; (c) Studies focused on epistatis and gene - environment interactions; (d) Analysis of the functional implications of genomic sequence variation and aim to attach physiological or pharmacogenomic relevance to alterations in genes or proteins; (e) Studies of DNA copy number variants, non-coding RNA, genome deletions, insertions, duplications and other single nucleotide polymorphisms and their relevance to physiology or pharmacology in humans or model organisms, in vitro or in vivo; and (f) Theoretical approaches to analysis of sequence vaAnalysis of the functional implications of genomic sequence variation and aim to attach physiological or pharmacogenomic relevance to alterations in genes or proteins; (e) Studies of DNA copy number variants, non-coding RNA, genome deletions, insertions, duplications and other single nucleotide polymorphisms and their relevance to physiology or pharmacology in humans or model organisms, in vitro or in vivo; and (f) Theoretical approaches to analysis of sequence vaanalysis of sequence variation.

The polyT repeat in intron 6 of TOMM40 (rs10524523) was genotyped using fluorescence - based fragment size analysis (Supplemental Figure 1; http://neuroscienceresearch.wustl.edu/pages/cruchaga2011.aspx).19 A detailed explanation of the fluorescence - based fragment size genotyping, quality control steps, allele frequency, and linkage disequilibrium between the studied polymorphisms can be found at http://neuroscienceresearch.wustl.edu/Pages/cruchaga2011.aspx.

In this project, I applied NASP for single nucleotide polymorphism (SNP) identification and characterization, and used FigTree and PHYLOBar for phylogenetic analysis and visualization.The NASP method differs from other published SNP pipelines in terms of supported short - read aligners and SNP callers, the ability to call both monomorphic and polymorphic sites, and the ability to integrate the results from multiple SNP callers and identify the consensus set of SNPs that define the population structure.

260/4: 45 Large scale analysis of interracial differences in genetic polymorphisms of CYP2C9, CYP2C19, CYP2D6, CYP3A4, and CYP3A5 in the U.S. population.

Methods: Here we genotype 276 single nucleotide polymorphisms (SNPs) in 5199 P. falciparum isolates from two Kenyan sites and one Gambian site to determine the spatio - temporal extent of parasite mixing, and use Principal Component Analysis (PCA) and linear regression to examine the relationship between genetic relatedness and relatedness in space and time for parasite pairs.

Genome sequence analysis was performed on multiple culture time point samples from six monoclonal isolates, and single nucleotide polymorphism (SNP) variants emerging over time were detected.

Meta - analysis of the BDNF Val66Met polymorphism in major depressive disorder: effects of gender and ethnicity.

Whole genome association analysis studies that utilize single nucleotide polymorphism (SNP) markers have been used to identify the molecular causes of various traits and conditions including genetic mutations within breeds that cause coat color variations [15], hairlessness [25] and defects in spinal development [26].

A factor analysis based on descriptors of 81 Labrador retrievers being trained as guide dogs found that polymorphisms in two genes — comt and the glutamate receptor (slc1a2)-- significantly related to a principal component described as «activity».

Molecular genome - wide association analyses have identified single nucleotide polymorphisms that segregate with the boldness - shyness axis in dogs [10, 11].

Association analysis of the catechol - o - methyltransferase (COMT), serotonin transporter (5 - HTT) and serotonin 2A receptor (5HT2A) gene polymorphisms with obsessive - compulsive disorder

Mesh terms: Aggression Analysis of Variance Animals Behavior, Animal Genetic Variation Macaca mulatta Male Maternal Deprivation Monoamine Oxidase Polymorphism, Genetic Promoter Regions, Genetic Random Allocation Social Environment

A meta - analysis of association studies between the 10 - repeat allele of a VNTR polymorphism in the 3 ′ UTR of dopamine transporter gene and attention deficit hyperactivity disorder

With the caveat in mind that FR - EXT may reflect both genetic and environmental influences, the availability of DNA analysis in the next future will allow us to refine our analyses by including genetic polymorphisms as risk factors.

Analysis of DRD4 and DAT polymorphisms and behavioral inhibition in healthy adults: implications for impulsivity

Association analysis between a functional polymorphism in the monoamine oxidase A gene promoter and severe mood disorders

A meta - analysis of the association between the serotonin transporter gene polymorphism (5 - HTTLPR) and trait anxiety

For instance, developmental studies of common dopamine (DA)- regulating gene polymorphisms and their interactions with environmental factors, both positive and negative, were recently examined in meta - analysis by Bakermans - Kranenburg and van Ijzendoorn (2011).

An exploratory genetic analysis: Associations between parent depression symptoms, child temperament, and the serotonin transporter gene polymorphism (5HTTLPR).