Sentences with phrase «polymorphisms at»

Further, existing research has been limited to one or two functional polymorphisms at the expense of a more comprehensive assessment of the serotonin system.

Interestingly, the three most common SNP variants detected in the LNCaP and 22Rv1 - associated XMRV genomes, the aforementioned A → G polymorphism at position 790, an A → G polymorphism at position 4264 and a C → G polymorphism at position 8112, can also be found in the VP35, VP42, and VP62 XMRV genomes, with the exception that the C → G polymorphism is not observed in VP35 due to lack of sequence coverage.

A lot of people with Hashimoto's and hypothyroid autoimmune issues tend to have a vitamin D polymorphism at the receptor site of the vitamin D receptor and they need higher levels of vitamin D, 70 to a hundred.

Not exact matches

Observed parenting behaviors interact with a polymorphism of the brain - derived neurotrophic factor gene to predict the emergence of oppositional defiant and callous — unemotional behaviors at age 3 years

DNA polymorphism in the Y chromosome, examined at a 729 - base pair intron located immediately upstream of the ZFY zinc - finger exon, revealed no sequence variation in a worldwide sample of 38 human males.

Fully sequenced genomes remain rare, so the bulk of the analysis was done by looking at genetic markers known as single nucleotide polymorphisms or SNPs.

Reviewing thousands of genome wide associate studies (GWAS) to identify genetic variants in single nucleotide polymorphisms (SNPs), investigators at Dartmouth's Norris Cotton Cancer Center found that some alleles (one of a pair of genes located on a specific chromosome) are more frequently risk - associated with disease than protective.

The research team's hunt for such age - related genetic associations involved studying more than 8 million single nucleotide polymorphisms — changes of one nucleotide for another at a particular spot in the DNA — in 2,693 individuals.

The research looked at more than five million genetic variations, called single nucleotide polymorphisms or SNPs (pronounced «snips»), in each participant in the study and compared the frequency of these SNPs with that of the control subjects.

A team at Virginia Commonwealth University in Richmond recently found that three genetic polymorphisms — variants in the «spelling» of a certain gene — are connected to nicotine addiction.

Past studies looked at the phylogeny (evolution and diversification) of the species in southern parts of Asia based on DNA polymorphisms.

The researchers looked at functional single nucleotide polymorphisms within the CLOCK gene that are able to influence how much protein is transcribed from the gene.

They add: «What is similar between now and then is the human genetic material, our genome, including ancient polymorphisms that were uncovered to predispose the carrier to the development of atherosclerotic cardiovascular disease... however, our ancient ancestors were certainly susceptible to many other conditions, such as infectious diseases, nutritional deprivation, and trauma, which often resulted in death at an early age, before atherosclerotic heart disease had a clinical impact.»

From beetles collected at 27 sites in Alberta and British Columbia, they looked for any patterns amongst their catalog of 1536 mutations (single - nucleotide polymorphisms, or SNPs).

Each of the genetic variants studied by the researchers is a single - nucleotide polymorphism, or SNP — a site at which the DNA code is altered by a single «letter» or nucleotide in some individuals, and where one «letter» is more commonly found in individuals with higher fracture risk.

People with the newly identified polymorphism, or form of this gene, appear to be at twice the risk of developing bipolar disorder, though it is not yet clear exactly why, says Blair.

In 2003, Nir Barzilai and Gil Atzmon, who study aging at Albert Einstein College of Medicine in New York, discovered that people with a certain polymorphism of the cholesterol - influencing gene CETP lived longer than those without it (ScienceNOW, October 2003).

She started her scientific career as an undergraduate and then PhD fellow at the Pasteur Institute, Paris, France, uncovering the molecular basis of IFN - induced OAS proteins in mediating resistance to West Nile virus infection and characterizing the molecular mechanism of action of DC - SIGN surface lectin polymorphisms that associate with severe Dengue hemorrhagic fever.

The ubiquity of these markers and the fact that these polymorphisms show variation at such a fine scale (i.e., at the individual level) makes them ideal markers for many applications, such as population - level genetic diversity studies and genetic mapping in plants.

PULLMAN — Researchers at Washington State University have identified a new class of DNA sequence variation in gene promoter regions that could help control the activity of genes.The novel variations, dubbed «multiple nucleotide length polymorphisms,» or MNLPs, altered transcription of the genes they were associated with as much as 11-fold.

«Here we see that the same IL - 21B gene polymorphisms seem to influence the response to influenza virus vaccination, at least in a population of transplant patients who, because of their transplant status, have to receive immunosuppressing drugs.

Similarly, in cancer genomics, a candidate somatic mutation observed at the position of a known polymorphism typically indicated a germline variant that was under - called in the normal sample.

The plasmids targeting each gene were respectively transfected into goat fibroblasts, and their genome modification efficiency was determined at day 3 using restriction fragment length polymorphism (RFLP) assay (see Methods).

Second, we calculated the proportion of fixed differences versus shared polymorphisms for each window and compared it to the genome - wide expectation using a Fisher's exact test, and setting the significance threshold at P < 0.01.

Jensen - Seaman, who is now at the University of Chicago, reported that chimpanzees, gorillas, and orangutans lack the 120/240 polymorphism, but the repeat is present in great apes.

Various biological factors at baseline appear to predict response to rTMS, including levels of certain molecular factors, blood flow in brain regions implicated in depression, electrophysiological findings, and specific genetic polymorphisms.

The polyT repeat in intron 6 of TOMM40 (rs10524523) was genotyped using fluorescence - based fragment size analysis (Supplemental Figure 1; http://neuroscienceresearch.wustl.edu/pages/cruchaga2011.aspx).19 A detailed explanation of the fluorescence - based fragment size genotyping, quality control steps, allele frequency, and linkage disequilibrium between the studied polymorphisms can be found at http://neuroscienceresearch.wustl.edu/Pages/cruchaga2011.aspx.

Results We did not replicate the previously reported association of the polyT polymorphism (rs10524523) with risk and age at onset.

When these errors are corrected on the basis of redundant deep sequencing coverage, the final consensus sequences of VP35, VP42, and VP62 are identical to each other and to the 22Rv1 consensus sequence, including a previously described natural polymorphism (A → G) at position 790 [23], [38].

Single nucleotide polymorphism -LRB--468 Gly to A) at the promoter region of SREBP - 1c associates with genetic defect of fructose - induced hepatic lipogenesis [corrected].

Scanning for variants, the group identified the top 25 polymorphisms that were unique to the Bajau genomes, suggesting natural selection pressures were at work.

A natural A → G polymorphism in the XMRV genome [23], [38] is present at position 790 (cyan lollipop).

Here, I'd like to chip away at one small piece of the puzzle that I have not written about yet: why benefits from SAMe supplementation should cause one to look not only at the most commonly discussed methylation nutrients (e.g., B12, folate, choline, betaine, methionine) and genetic polymorphisms (e.g., MTHFR) but also at issues that are more commonly neglected when discussing methylation: magnesium and the metabolic rate.

Uhm — A lot of times, people will look at their COMT polymorphism and they'll say, «Oh.

So it — we just looked at genetic polymorphisms, and we could look at an organic acids test to see what snips or — or genetic snips are uhm — expressing.

So, it's common for alcoholics to have uh — at least one or two copies of that polymorphism.

Siberian Huskies possessing at least one short allele of the DRD4 polymorphism displayed greater activity in a behavioural test battery than those with two long alleles.

[4][5] In 2010, a study looked at 48,000 Single nucleotide polymorphisms that gave a genome - wide coverage of 912 dogs representing 85 breeds.

In 2012, a study looked at 49,000 Single nucleotide polymorphisms that gave a genome - wide coverage of 1,375 dogs representing 35 breeds, 19 wolves, and previous published genetic signatures of other breeds, giving a total of 121 breeds covered.

A misconception that the Phosducin (PDC) gene is associated with Type A PRA has caused at least one laboratory to incorrectly identify a benign DNA sequence change (termed a «polymorphism») in the Phosducin gene as the Type A PRA mutation.

This dynamic group of young people have just finished working with artist Siobhán McGibbon on a process - based sculpture project which culminated in Polymorphism, an exhibition at the end of January.

/ exhibitions 2017 Co • — st • — l W • — ve Tr • — nsl • — tor, RAFT artist - run space, Elizabeth Quay, Perth 2016 Longli International New Media Art Festival, Longli Ancient Town, Jinping County, Guizhou Province, China 2016 Polymorphism, Ideas Platform, Artspace, Sydney 2016 Automated Reasoning Paradigm, Firstdraft Gallery, Sydney 2015 Didactic Tools, Fremantle Arts Centre, Perth 2015 Dead Ringer, curated by Leigh Robb, Perth Institute of Contemporary Arts 2015 Pica Salon, curated by Leigh Robb and Nadia Johnson, Perth Institute of Contemporary Arts 2015 sculptures: 5, The Auricle, Christchurch, New Zealand 2015 Firstdraft Auction, Firstdraft Gallery, Sydney 2014 What I See When I Look At Sound, curated by Leigh Robb, Perth Institute of Contemporary Arts 2014 Print Award, Fremantle Arts Centre 2014 hyperthymesia, State of the Art Festival, State Library of Western Australia 2014 sculptures: 4, Firstdraft Gallery, Sydney 2014 perspectives [micro], NOW now Festival Group Show, SNO Gallery, Sydney 2013 perspectives [macro], free range gallery, Perth 2013 Open Curator Studio, Artspace, curated by Alana Kushnir, Sydney / online 2012 NH7 festival, Pune, India 2011 Wonderland, Museum of Contemporary Art, Taipei, Taiwan 2010 hypnogenia, Scitech Science Museum, Perth

In conclusion, there exists a robust relationship between the cultural construct individualism — collectivism and the prevalence of alleles at several polymorphisms with apparent psychological effects.

In addition, at the genetic level, there is good reason to suspect that the polymorphisms discussed here may be associated with depression.

However, researchers at the University of California — Berkeley wanted to find out if there might a genetic component that could predict how couple interactions affect marital satisfaction.5 Specifically, the team decided to look at the 5 - HTTLPR polymorphism in the promoter region of the serotonin transporter gene.

This investigation examined the extent to which polymorphisms of the serotonin transporter linked promoter region (5 - HTTLPR) and the dopamine receptor D4 (DRD4) genes differentially influenced the development of attachment security and disorganization in maltreated and nonmaltreated infants at age 13 months, and the extent to which the efficacy of preventive interventions to promote attachment security were influenced by genetic variation.

In this study, we examined possible two - and three - way interactions and child DRD4 polymorphisms and birth weight and maternal caregiving at age 6 months in longitudinally predicting attachment disorganization at 36 months.

The recommendation is to check for interaction with other polymorphisms (see, for example the replicability of «novelty seeking», where interaction of at least three gene loci made replication uncertain [122].

Adults who had been categorized as behaviorally inhibited at the age of 2 years exhibited a higher amygdala activation in response to unknown vs familiar faces16 compared with adults who were uninhibited as children, consistent with the notion that novel or ambiguous environmental stimuli of potential biological relevance activate the amygdala.17 Turning to genes that can influence the neurobiological bases of the processing of emotions, 2 common alleles, the short (S) and the long (L), in a variable repeat sequence of the serotonin transporter (5 - HTT) promoter polymorphism (5 - HTTLPR) on human chromosome 17q11 have been differently associated with greater amygdala activity in response to angry or fearful faces18 in healthy adults.

Results indicated that maternal positive and negative parenting significantly concurrently predicted adolescent depressive symptoms at all three waves, whereas TaqIA polymorphism had no main effect on depressive symptoms.