Sentences with phrase «population of cells found»

The research team with international collaborators analysed more than 100 patient samples from ovarian and other cancer types to discover a distinct population of cells found in some tumours.

Not exact matches

They're not the only ones, of course, since political organizers from Manila to D.C. have found that cell phones are profoundly political devices, particularly when they reach populations that are otherwise effectively off the grid.

In the new study, led by graduate student Steven Briscoe, the team found that other populations of neurons in the bird DVR share molecular signatures with neocortical intratelencephalic cells, or IT neurons.

Prof. Jean - Christophe Marine (VIB - KU Leuven): «Unexpectedly, this ability to divide and contribute to melanoma development contrasted with the activities of other cell populations, such as melanocyte stem cells found in hair follicles, for instance.

Instead, the team used functional magnetic resonance imaging (fMRI) to detect populations of cells that seemed to fire as the volunteers played a virtual reality game in which they had to replace an object in the location where they originally found it.

«What our findings show is that the problems with iPS cells don't just involve one or two or a few abnormal iPS cells escaping into the body and forming tumors, but that the whole population of cells is screwed up,» Lanza says.

The findings, published Aug. 31 in the journal Science Advances, could also lead to a simple, scalable and inexpensive way to manufacture a pure population of bone - building cells.

In this study, the researchers found that a specific population of immune cells called macrophages have the ability to secrete or produce a protective or healing factor known as Interleukin - 10 (IL - 10), which can interact with receptors on intestinal epithelial cells to promote wound healing.

Dr Ignacio Vazquez - Garcia, the first author from the Wellcome Trust Sanger Institute and University of Cambridge, said: «We found that the degree of diversity within the cell population — known as clonal heterogeneity — played a major role in the acquisition of antimicrobial resistance.

The research team found that the experimental group had an imbalance of cell populations in breast tissue: too many luminal and too few basal.

Participants with high - risk bacterial communities, which are commonly found in the population of women studied, also had increased numbers of genital CD4 + T cells — white blood cells that are HIV's primary target.

This was good proof that gp96 is needed to maintain the proper balance of T cell populations, but Liu and her group wanted to connect that finding to a biological function relevant to humans.

Scientists have found some serious loot in that bemoaned organ, including a vigorous population of flexible stem cells that can be coaxed into acting as new cartilage or tendons for damaged joints.

The investigators also found that sickle cell trait was slightly more common among dialysis patients, present in 10 % of study participants compared with 6.5 % to 8.7 % in the general African - American population.

Now a team of engineers at MIT has developed a new way to deliver such vaccines directly to the lymph nodes, where huge populations of immune cells reside: These vaccines hitch a ride to the lymph nodes by latching on to the protein albumin, found in the bloodstream.

Reporting their laboratory findings in the journal Aging, the team observed that addition of DPI to a mixed population of cells eliminated the tumour initiating cancer stem cells.

In order to eradicate those HIV reservoirs, researchers must find a way to eliminate persistent populations of cells with integrated HIV proviruses.

Dr Saraswat explained that the impact of endometriosis — a relatively common condition in which cells from the lining of the uterus (endometrium) are found elsewhere in the pelvic area — is relatively unknown in pregnancy in general populations of women, with most studies performed in infertile women having assisted reproduction.

«Previously, we thought that all of the cells in the corneal endothelium were unable to divide, but we were surprised to find this small population of dormant stem cells capable of proliferating,» said principal investigator Ula Jurkunas, M.D., a corneal and refractive surgeon at Massachusetts Eye and Ear and Associate Professor of Ophthalmology at Harvard Medical School.

Most of the cells that made up the tumors were positive for CA125, but the researchers found a small population that were negative and focused on those, Janzen said.

Border cells are relatively sparse, making up less than 10 % of the local cell population, but can be found in all layers of the medial entorhinal cortex as well as the adjacent parasubiculum, often intermingled with head - direction cells and grid cells.

This finding comes as a surprise, considering that the average migration speed of the larger cell population does not change through multiple cycles.

The second branch of the combination therapy, the low - dose metronomic chemotherapy, was similarly found to exert its therapeutic effect through a novel, hitherto unrecognized mechanism: The metronomic chemotherapy turned out to not primarily target the tumor cells, but to act on the recruitment of yet another tumor - promoting cell population from the bone marrow.

They found that the populations of cells destined to become face and forebrain began to die.

The researchers tested the drug on mice with H. pylori infections from several different cell lines, and found that the drug was effective against the H. pylori while maintaining populations of healthy gut bacteria.

This phenomenon, which indicates the presence of different mitochondrial DNA types in a cell or an individual, can be found in more than half of the population.

The human influenza virus H1N1 that caused the 2009 flu pandemic, and H9N2, an avian influenza virus that is endemic in bird populations in Asia, are close cousins — close enough that they can swap genes if they find themselves in the same cell, resulting in new viruses that are a patchwork of the parent strains.

To devise a potential new therapy, the investigators engineered a population of neural stem cells to express a potent version of a gene called TRAIL, which codes for a molecule that activates cell - death - inducing receptors found only on the surface of cancer cells.

Humphreys does caution that the cell population his lab found is responsible for about 60 percent of all organ myofibroblasts, which means that they seem to be the most dominant source, but that there may be other cells that also contribute to the myofibroblast population.

However, another report found that miR - 7 expression correlated with poorer prognosis of breast cancer, and these apparently conflicting results suggest that miR - 7 may be differentially expressed in a specific cell population of breast cancer (26).

The researchers, led by Benjamin Humphreys, MD, PhD, found that a rare population of stem cells located outside of blood vessels in mice become myofibroblast cells that secrete proteins that cause scar tissue.

The researchers also found that another population known as progenitor cells — differentiated daughter cells of stem cells — started to behave like stem cells: They began to live much longer than their usual lifespan of a few days, and they could also generate mini-intestines when grown outside of the body.

In a paper published in the March 25, 2010 issue of Nature, researchers working at the Salk Institute for Biological Studies and the Center of Regenerative Medicine in Barcelona (CMRB) identified a fish heart cell population that is the source of this astonishing healing feat, a finding that could provide insight into how mammalian hearts might be coaxed into repairing themselves after injury brought on by heart attack.

As an additional finding, we observed little stimulation of purified naive DGKζ - deficient CD8 + T cells, relative to Cbl - b — deficient or DKO cells (compare Fig. 3A with Fig. 3D), at limiting dilutions of anti-CD3 (0.3 μg / ml), when compared with DGKζ - deficient T cells in a mixed population.

The current study finds the p16 (Ink4a) cell population largely consists of SAMs, thus providing powerful argument in favor of significant contribution of SAMs to aging.

Small, transient populations of these totipotent cells are found in both mouse and human cultured stem cells.

These findings strongly suggest that we have succeeded in isolating a unique metastatic CSC population by exposing breast cancer cells to repetitive cycles of hypoxia and reoxygenation.

Interestingly, an increased fraction of the cell population was found to express CD44 + / CD24 - / ESA + cell surface markers.

They hypothesized that, if they labeled the parent cell population using the library, propagated it, separated it into roughly identical replicate groups, and treated these groups with the same drug regimen, they would find one of two outcomes (see schematic depiction below):

Small populations of immature nerve cells are found in the adult mammalian brain, a process called neurogenesis.

Assuming that the findings of the review reflected a causal relation between smoking cessation and risk of all cause mortality, we further investigated the data by constructing life tables for a hypothetical group of 100 patients aged 65 years with early stage lung cancer to estimate how many deaths would be prevented by smoking cessation within the non-small cell lung cancer and small cell lung cancer populations during five years.

«Finding this population of stem cells in a human source represents a major breakthrough for us because it brings us much closer to a clinical application of this therapy,» said Dr. Huard, the Henry J. Mankin Professor and vice chair for Research in the Department of Orthopaedic Surgery at the University of Pittsburgh School of Medicine.

The finding shows that this population of cells in the human brain is more similar to that of a macaque than a chimp brain.

Since V + cells were found abundantly in the SSEA - 1 positive population, we asked whether this population expressed other markers of the undifferentiated state.

We found that the V+S + population expressed sets of genes that fell into major functional categories that were associated with «Cell adhesion» and «Cell migration.»

Here, we elaborate on how these findings pertain to cancer cells dispersed in the tumor - adjacent stroma of breast cancer tissues, and how BH3 - mimetics may provide a therapeutic strategy to eliminate cancer cell populations that have passed through an EMT.

Our findings suggest that pluripotency is determined by the capacity of a mixed population of lineage - biased intermediates to commit to different cell fates in specific contexts.

Based on previous protocols [5, 6] they have now created a 3D protocol for chondrogenic lineage differentiation via the generation of a putative chondrogenic progenitor cell population, and have found that using this protocol C - iPSCs can be readily differentiated into cartilage in a manner comparable to that of mature chondrocytes [7].

Because of small sample size, the changes in tumor - initiating cell number were not significant (P > 0.05), but these data are supportive of the in vitro findings and suggest that hypoxia may have a positive effect on the tumor - initiating cell population in ER - α — positive breast cancers and a negative effect in ER - α — negative tumors.

Through image analysis of breast tumors and TDLNs, we have found that immune cell populations as well as their spatial distributions and clustering patterns have strong correlation with clinical outcome.