Sentences with phrase «populations of cells»

«What we have to recognize... is that if cancer is a mitochondrial metabolic disease and you get cancer because of mitochondrial failure in certain populations of cells and certain tissues, if you prevent your mitochondria from entering into this dysfunctional state... [then] the probability of getting cancer is going to be significantly reduced.

Over time, specific populations of cells in the brain become dysfunctional or die.

Scientists can use the technique to develop populations of cells with abnormalities that lead to disease.

The tumor microenvironment is comprised of heterogeneous populations of cells including cancer, immune and tumor associated stromal cells.

This suggests that our automatic screening assay is specifically measuring the effect amiodarone HCL has on different populations of cells.

Single - cell transcriptomics serves as a powerful tool to identify cell states within populations of cells, and to dissect underlying heterogeneity at high resolution.

There are populations of cells that divide in the mature brain, and the knowledge we gain from the in vitro studies could help influence how one might be able to manipulate and use that newly generated population of cells in the brain in more therapeutic ways.

To further test this, we reasoned that populations of cells with a greater basal expression of ion channel activity mediators would be most susceptible to drug treatment.

In a sort of molecular «Where's Waldo,» scientists are often left with no choice but to measure a disease's effects on populations of cells, rather than a single cell.

In addition to the SSEA3 - positive and negative populations of cells, which represented the top 10 % and bottom 10 % of SSEA3 expressing cells respectively, we also included the intermediary SSEA3 - expressing cells, which represented the remaining 80 % of the total HUF1 cell population.

Many in vivo processes, including morphogenesis or tumour maturation, involve small populations of cells within a spatially restricted region.

The center will develop new approaches that overcome inherent limitations in traditional techniques, which analyze bulk populations of cells, thereby obscuring individual cell behavior.

Pair-wise comparisons (FDR < 0.05, > 1.5-fold expression levels) were performed between the following populations of cells to reveal non-redundant, significant changes in gene expression.

Since synchronized oscillations between populations of cells distinguished between visual stimuli, it's theoretically possible to determine the correct answers for the matching tasks the monkeys performed simply by reading their brain waves.

The players are the healthy cells, the targeted cancer cells and the resistant cancer cells and the game is played over and over again in the computer simulation as the different populations of cells compete.

Today, analyzing and editing genomes, proteomes and metabolomes has become a standard for many model systems; imaging beyond the diffraction limit of light and new technologies for studying protein structures provide insights deeper than ever before; the characterization of large populations of cells or organisms brings unprecedented statistical power; and studying nearly all organisms of an ecosystems as a whole allows generating comprehensive models.

The center also develops new approaches that overcome inherent limitations in traditional techniques, which analyze bulk populations of cells, thereby obscuring individual cell behavior.

The ability to make pure populations of these cells within days rather than the weeks or months previously required is a key step toward clinically useful regenerative medicine — potentially allowing researchers to generate new beating heart cells to repair damage after a heart attack or to create cartilage or bone to reinvigorate creaky joints or heal from trauma.

The center will develop new single - cell approaches that overcome limitations inherent in traditional techniques — which analyze bulk populations of cells, thereby obscuring individual cell behavior.

The new study from Tonegawa's group builds on previous research demonstrating that episodic memories are physically represented in populations of cells in parts of the hippocampus.

They found that the populations of cells destined to become face and forebrain began to die.

«We have identified two new populations of cells in the brain that potently regulate appetite,» says Alexander Nectow, first author of the paper, published in Cell on July 27.

Most theorists assume that such a complex concept must be supported by large populations of cells, each of which corresponds to one component of the object (the bun, the bifocals, the leather miniskirt).

A single tumor is composed of many different populations of cells.

Located near the center of the brain, the nucleus accumbens is connected, by intermingled populations of cells, to many other brain structures having roles in pleasure seeking and drug addiction.

That is, they contained multiple populations of cells, including the so - called JARID1B cells, which their research suggested was responsible for allowing tumors to survive drug therapy.

However, due to technological limitations, previous genetic studies largely focused on mixed populations of cells, obscuring critical nuances in cellular behavior.

Tumors, for example, are known to contain different populations of cells, some of which are quite different to each other in their genetic makeup.

In order to eradicate those HIV reservoirs, researchers must find a way to eliminate persistent populations of cells with integrated HIV proviruses.

«What David's group can do is grow populations of cells in a very miniaturized state in ways that they can reach out and talk to each other through tiny channels, but yet they stay distinct,» den Boon says.

New techniques have made it possible to study the arrangement and interconnections of entire populations of cells

For instance, researchers often use so - called «gene guns» to fire particles coated with strands of DNA known as plasmids at large populations of cells.

Researchers in this study used budding yeast, creating populations of cells with more than 10 million different randomised genomes, to investigate how genetic diversity affected resistance.

Most theorists assume that such a complex concept would have to be supported by large populations of cells, each of which corresponds to one component of the object (the bun, the bifocals, the leather miniskirt).

Previous studies have examined cancer stem cells (CSCs)-- small populations of cells within a tumor that are resistant to chemotherapy.

She works to isolate populations of these cells, discover how the body regulates them, and understand how they can be used to treat disease.

Instead, the team used functional magnetic resonance imaging (fMRI) to detect populations of cells that seemed to fire as the volunteers played a virtual reality game in which they had to replace an object in the location where they originally found it.

However, the MIT team adapted it to randomly turn on or off distinct gene sets across large populations of cells, allowing the researchers to identify genes that protect cells from a protein associated with Parkinson's disease.

In the clearest possible case, the ANT - OAR cell would differ from a zygote on all of the parameters noted above: The ANT - OAR cell would have a pattern of gene expression that is clearly distinct from a zygote; it would generate a homogeneous population of cells rather than multiple cell types; it would undergo simple cleavage divisions and not produce any multicellular structures.

Since the population of cells down there is small, most people thought they would just barely be able to eke out a living, that they were organisms with very few capabilities.

«Computerized biology, or how to control a population of cells with a computer.»

In the course of examining single unit responses from the cortex of unrestrained and unanesthetized cats, we have come upon a population of cells that appears to be sensitive to auditory stimuli only if the cat «pays attention» to the sound source.

Tumours grow through a process of Darwinian evolution, where cancer cells develop an advantageous mutation that allows them to survive and multiply, producing a population of cells which can mutate further.

«What our findings show is that the problems with iPS cells don't just involve one or two or a few abnormal iPS cells escaping into the body and forming tumors, but that the whole population of cells is screwed up,» Lanza says.

In the last few years, a bulk of data pointing to a small population of cells in tumors that maintain tumor growth, are particularly resistant to chemotherapy, are responsible for relapses, and develop metastases.

If such a population of cells existed, women might be able to produce new eggs later in life.

But M. genitalium grows so slowly that a population of cells can take weeks to double.

The KU researcher said that new evidence suggests that cancer originates and progresses by a small population of cells known as cancer stem cells.

Within a single tumor exists such an astonishingly varied population of cells, each with its own combination of normal and abnormal genes, that at least some cells nearly always have a way to survive any particular attack.

«Young students of cognitive neuroscience are lucky to be in the midst of a new era where we have access to amazing new tools of science for eavesdropping on the population of cells with a superb temporal resolution,» Parvizi says.