Sentences with phrase «populations of cells with»

Scientists can use the technique to develop populations of cells with abnormalities that lead to disease.

To further test this, we reasoned that populations of cells with a greater basal expression of ion channel activity mediators would be most susceptible to drug treatment.

In order to eradicate those HIV reservoirs, researchers must find a way to eliminate persistent populations of cells with integrated HIV proviruses.

Researchers in this study used budding yeast, creating populations of cells with more than 10 million different randomised genomes, to investigate how genetic diversity affected resistance.

«Computerized biology, or how to control a population of cells with a computer.»

«Young students of cognitive neuroscience are lucky to be in the midst of a new era where we have access to amazing new tools of science for eavesdropping on the population of cells with a superb temporal resolution,» Parvizi says.

This gave a mixed population of cells with 20 % expressing CD34, a hematopoietic stem cell marker, with some co-expression of endothelial cell markers (CD31, Flk1, and VE - cadherin).

The ClonTracer library allows a researcher to label individual members of a starting population of cells with specifc, easily read sequences that can be used to measure their clonal abundance before and after a treatment.

This gradient of surface antigen expression was paralleled by a gradient in expression of pluripotency genes, with highest levels of genes like Oct - 4 found in the population of cells with the highest level of antigen expression.

Not exact matches

And with 7billion on the planet (and growing), these «young people missing millions from their generation» should be thankful that clusters of cells can be medically removed, preventing unwanted births and (perhaps) even saving the human population from growing to a point of unsustainability.

I know it's popular to think of movies where Floyd is sharing his cell with a hardened criminal and having to worry about being shanked, but it's much more likely that he spends a bunch of time away from general population, being kept safe and probably watching TV and reading his days away.

With 212 million cell phone users in the US — about 75 % of the population — the potential for using mobile phones («mo - phos,» as the kids call them) as a tool to grow your organization's visibility and spread your message is enormous.

The design features a central viewing chamber with a system of mirrors that allows a single guard to keep watch on the entire prison population in their cells.

Since the population of cells down there is small, most people thought they would just barely be able to eke out a living, that they were organisms with very few capabilities.

In addition to maintaining stem cell populations and keeping the brain supplied with all its cell types, the investigators showed that NAD also is vital for the process of cognition itself.

In the new study, led by graduate student Steven Briscoe, the team found that other populations of neurons in the bird DVR share molecular signatures with neocortical intratelencephalic cells, or IT neurons.

However, the MIT team adapted it to randomly turn on or off distinct gene sets across large populations of cells, allowing the researchers to identify genes that protect cells from a protein associated with Parkinson's disease.

Prof. Jean - Christophe Marine (VIB - KU Leuven): «Unexpectedly, this ability to divide and contribute to melanoma development contrasted with the activities of other cell populations, such as melanocyte stem cells found in hair follicles, for instance.

Small populations of adult stem cells with somewhat limited developmental potential are responsible for the body's ability to heal injuries and replace worn out cells and tissues, and evidence is growing that rare cancer stem cells are responsible for the uncontrolled growth of some malignant tumors, including glioblastoma.

«What our findings show is that the problems with iPS cells don't just involve one or two or a few abnormal iPS cells escaping into the body and forming tumors, but that the whole population of cells is screwed up,» Lanza says.

However, along with this seemingly linear storyline in which retinoids block progesterone's promotion of CK5 + cells, previous work in the lab of CU Cancer Center investigator Peter Kabos, MD, and others shows that breast cancers treated with anti-estrogen drugs like tamoxifen or aromatase inhibitors show an increased population of CK5 + cells — it is as if these therapies remove the roadblock of estrogen - dependent cells, leaving CK5 + cells to proliferate.

Subsequent tests revealed that the treatment had reduced the visible cell population by a factor of 100 thousand, compared with an untreated cell culture, within the space of just 20 days.

The process involves the reversion of delta cells (which produce somatostatin, another pancreatic hormone) to a precursor - like cell state, with proliferation and later reconstitution of the populations of beta and delta cells.

They demonstrated that non-obese diabetic (NOD) mice treated with a specific (AID / RAD51) pathway inhibitor had larger populations of certain B cells that were capable of suppressing diabetogenic T cell responses, and greatly reduced T1D development, compared with untreated controls.

In this study, the researchers found that a specific population of immune cells called macrophages have the ability to secrete or produce a protective or healing factor known as Interleukin - 10 (IL - 10), which can interact with receptors on intestinal epithelial cells to promote wound healing.

Within a single tumor exists such an astonishingly varied population of cells, each with its own combination of normal and abnormal genes, that at least some cells nearly always have a way to survive any particular attack.

Now, a team of scientists at the Icahn School of Medicine at Mount Sinai have developed the Just EGFP Death - Inducing T - cell, or JEDI T - cells, which enable the visualization of T - cell antigens, allowing researchers to study T - cell interactions with different cell types, model disease states, and finally determine the functions of otherwise poorly characterized cell populations.

Saatchi, which is owned by France's Publicis Groupe, SA, chose LifeStraw over a field of competitors that included a reusable controller to improve the distribution of IV fluids, a collapsible wheel that can be folded down for easier storage when not in use on bicycles or wheelchairs, an energy - efficient laptop designed for children in developing countries, a 3 - D display that uses special optics and software to project a hologramlike image of patient anatomy for cancer treatment, an inkjet printing system for fabricating tissue scaffolds on which cells can be grown, a visual prosthesis for bypassing a diseased or damaged eye and sending signals directly to the brain, books with embedded sound tracks to help educate illiterate adults on health issues, a phone that provides telecommunications coverage to poor rural populations in developing countries, and a brain - computer interface designed to help paralyzed people communicate via neural signals.

Participants with high - risk bacterial communities, which are commonly found in the population of women studied, also had increased numbers of genital CD4 + T cells — white blood cells that are HIV's primary target.

For instance, researchers often use so - called «gene guns» to fire particles coated with strands of DNA known as plasmids at large populations of cells.

For Helicobacter pylori, a pathogenic bacterium that colonizes over 40 percent of the world population and is associated with gastric cancer, the team discovered that epigenetic heterogeneity can quickly emerge as a single cell divides, and different subpopulations with distinct methylation patterns have distinct gene expressions patterns.

In this mouse model, mutations in Kras and p53 genes resulted in the formation of individual tumor cell populations that were labeled with different colors.

By measuring for the presence of a molecule associated with cell division, the scientists determined that this residual population of dormant cancer cells consisted of an indolent as well as a quiescent population.

They might also come up with a way to select the right cells out of a mixed population; Anand Swaroop, an ophthalmology researcher at the University of Michigan at Ann Arbor, is working on a way to identify and weed out the photoreceptor cells by focusing on proteins present on cell surfaces.

The investigators also found that sickle cell trait was slightly more common among dialysis patients, present in 10 % of study participants compared with 6.5 % to 8.7 % in the general African - American population.

A couple of other research groups have also sorted stem cells based on gene expression, but they have not done so specifically with the goal of enriching cell populations for a specific tissue, the researchers said.

The research team with international collaborators analysed more than 100 patient samples from ovarian and other cancer types to discover a distinct population of cells found in some tumours.

«By combining the genetic analysis of a small population of immune cells from healthy skin with functional experiments we were able to define two subgroups of memory immune cell and in detail decipher / dissect how these cells behave in healthy and inflamed skin,» explains Liv Eidsmo, researcher at Karolinska Institutet's Department of Medicine.

«Secondary benefits of this trial include the significant improvement in clinical care for children with sickle cell disease at each of the 29 sites because each location had a designated hematologist, neurologist, neuroradiologist and psychologist working as a team to identify and decrease further injury to the brain in this vulnerable population.»

Dr Saraswat explained that the impact of endometriosis — a relatively common condition in which cells from the lining of the uterus (endometrium) are found elsewhere in the pelvic area — is relatively unknown in pregnancy in general populations of women, with most studies performed in infertile women having assisted reproduction.

«Ulcerative colitis is often associated with decreased mucus production and the worms seem to somehow restore mucus production, possibly by inducing a population of immune cells that make IL - 22,» Loke says.

It's been challenging to zoom in on the population of T cells driving the disease in part because when psoriasis is active, lesions are flooded with diverse T cells.

The study, which appears August 3 in the peer - reviewed journal Nature Communications, showed that pairing the chemotherapy with an experimental drug eliminates the deadly population of cells believed to be responsible for repopulating the tumor.

In a statement put on the Web this morning, NIH reported that all 64 lines «show characteristics of stem cell morphology» and have undergone several population doublings, and most of them have demonstrated all the protein markers «known to be associated with human embryonic stem cells.»

The technical milestone, presented January 24 in the journal Cell, makes it a realistic possibility for labs to conduct research with customizable populations of genetically uniform monkeys.

To investigate, researchers developed mathematical models to predict the dynamics of cell transitions, and compared their results with actual measurements of activity in cell populations.

Their recent study, which appears as the cover article in the May issue of Cancer Research, shows that mathematical models can be used to predict how different tumor cell populations interact with each other and respond to a changing environment.

Along with steroids, the mainstay of GVHD treatment today is drugs that turn down the production of IL - 2, a cytokine that helps T cell populations expand and diversify.

With the results from both Korea and the UK the presence of both diet and microbe - induced populations of pTreg cells may be required for the development of complete tolerance to food antigens.

Border cells are relatively sparse, making up less than 10 % of the local cell population, but can be found in all layers of the medial entorhinal cortex as well as the adjacent parasubiculum, often intermingled with head - direction cells and grid cells.