Every pork cell contains a virus called
Porcine Endogenous Retrovirus.
Now a team led by Robin Weiss of London's Institute of Cancer Research reports that the «PK»
porcine endogenous retrovirus, which does not appear to harm pigs, can replicate in mink and human cells.
Inactivation of
porcine endogenous retrovirus in pigs using CRISPR - Cas9.
Removing the viruses — called
porcine endogenous retroviruses, or PERVs — creates piglets that can't pass the viruses on to transplant recipients, geneticist Luhan Yang and colleagues report online August 10 in Science.
That's crucial, because the memorably named infectious agents, short for
porcine endogenous retroviruses, could cause tumors, leukemia, and neuronal degeneration if transplanted into patients.
Pig cells contain multiple copies of embedded viruses called
porcine endogenous retroviruses, or PERVs.
And in lab experiments,
these porcine endogenous retroviruses (PERVs) tended to leap from pig to human cells.
In the new study, a team led by Harvard University's George Church — one of the pioneers of the CRISPR technique — used gene editing to remove all the copies of
porcine endogenous retroviruses (or PERVs) from their pig cells» DNA.