Sentences with phrase «positions by mutation»

These structural and functional differences are not seen when cells are placed in similar positions by mutation or laser - induced damage.

Not exact matches

Most importantly, while I do agree that common descent is supported by the bulk of the evidence (although admittedly there are difficulties at higher phylogenetic levels), I certainly do not think we have any reason to suppose the process occurred by random mutation and natural selection, the position Prof. Arnhart attributes to me.

Derived by co-transfection of MT4 cells with PHXB2deltapro and PHXB2 proteinase coding region containing 2 mutations G → V at position 48, L → M at pos

Derived by co-transfection of MT4 cells with PHXB 2 delta pro and PHXB2 proteinase coding region containing a single G → V mutation at position 48.

Along the trajectories, active site mutations occurred, followed by other mutations that helped optimize the positioning of the residues in the new active sites.

Breast cancer risk was higher if mutations were located outside vs within the regions bounded by positions c.2282 - c. 4071 in BRCA1 (HR, 1.46; 95 % CI, 1.11 - 1.93; P =.007) and c.2831 - c. 6401 in BRCA2 (HR, 1.93; 95 % CI, 1.36 - 2.74; P <.001).

To understand the selection mechanism behind mutations, network - based studies were used to estimate the importance of a mutated protein compared to non-mutated ones in signalling and protein — protein interaction networks.10, 11,12,13 Proteins mutated in cancer were found having a high number of interacting partners (i.e., a high degree of connectivity), which indicates high local importance.10 Mutated proteins are also often found in the centre of the network, in key global positions, as quantified by the number of shortest paths passing through them if all proteins are connected with each other (i.e., they have high betweenness centrality; hereafter called betweenness).11, 12 Mutated proteins also have high clustering coefficients, which means their neighbours are also neighbours of each other.10, 13 Moreover, neighbourhood analysis of mutated proteins have been previously successfully used to predict novel cancer - related genes.14, 15 However, to the best of our knowledge, no study has concentrated particularly on the topological importance of first neighbours of mutated proteins in cancer, and their usefulness as drug targets themselves.

In Irish Setters, rcd1 is caused by a nonsense mutation G > A transition at nucleotide position 2420 in PDEB gene.

In summary, Doberman pinscher breeders are now in the advantageous position of being able to begin eliminating one of the significant diseases in their breed, because of the discovery of the mutation producing vWD in this breed, and the development of a vWD DNA test by VetGen.

Oppenheim speaks of growing up in Washington and California, his father's Russian ancestry and education in China, his father's career in engineering, his mother's background and education in English, living in Richmond El Cerrito, his mother's love of the arts, his father's feelings toward Russia, standing out in the community, his relationship with his older sister, attending Richmond High School, demographics of El Cerrito, his interest in athletics during high school, fitting in with the minority class in Richmond, prejudice and cultural dynamics of the 1950s, a lack of art education and philosophy classes during high school, Rebel Without a Cause, Richmond Trojans, hotrod clubs, the persona of a good student, playing by the rules of the art world, friendship with Jimmy De Maria and his relationship to Walter DeMaria, early skills as an artist, art and teachers in high school, attending California College of Arts and Crafts, homosexuality in the 1950s and 1960s, working and attending art school, professors at art school, attending Stanford, early sculptural work, depression, quitting school, getting married, and moving to Hawaii, becoming an entrepreneur, attending the University of Hawaii, going back to art school, radical art, painting, drawing, sculpture, the beats and the 1960s, motivations, studio work, theory and exposure to art, self - doubts, education in art history, Oakland Wedge, earth works, context and possession, Ground Systems, Directed Seeding, Cancelled Crop, studio art, documentation, use of science and disciplines in art, conceptual art, theoretical positions, sentiments and useful rage, Robert Smithson and earth works, Gerry Shum, Peter Hutchinson, ocean work and red dye, breaking patterns and attempting growth, body works, drug use and hippies, focusing on theory, turmoil, Max Kozloff's «Pygmalion Reversed,» artist as shaman and Jack Burnham, sync and acceptance of the art world, machine works, interrogating art and one's self, Vito Acconci, public art, artisans and architects, Fireworks, dysfunction in art, periods of fragmentation, bad art and autobiographical self - exposure, discovery, being judgmental of one's own work, critical dissent, impact of the 1950s and modernism, concern about placement in the art world, Gypsum Gypsies, mutations of objects, reading and writing, form and content, and phases of development.