Sentences with phrase «positive allosteric modulators»

Medical researchers are increasingly studying positive allosteric modulators because they target secondary drug receptor sites in the body.

The research, which appears in the journal Biological Psychiatry, finds that the use of compounds called positive allosteric modulators, or PAMs, enhances the effect of pain - relief chemicals naturally produced by the body in response to stress or injury.

Title: Selective Remediation of Reversal Learning Deficits in the Neurodevelopmental MAM Model of Schizophrenia by a Novel mGlu5 Positive Allosteric Modulator Author: F. Gastambide et al..

Muscarinic receptor M4 positive allosteric modulators attenuate central effects of cocaine...

The findings indicate that compounds known as positive allosteric modulators, or PAMS, can increase the natural pain - relief chemicals produced by the body in response to injury.

Administration of a positive allosteric modulator of the type 1 metabotropic glutamate receptors mGluR1 during the first postnatal week restored DA neuron excitatory synapse transmission and partially rescued the social preference defects, while optogenetic DA neuron stimulation was sufficient to enhance social preference.