In addition, ActD has been shown to mimic nutlin - 3 in the activation of p53 - dependent transcription, induction of a reversible protective growth arrest in normal cells, and enhancement of the activity of the chemotherapeutic drugs, melphalan and etoposide, resulting in apoptosis of p53
positive human tumor cells [14].
Not exact matches
Shah next plans to rationally combine the toxin - secreting stem
cells with a number of different therapeutic stem
cells developed by his team to further enhance their
positive results in mouse models of glioblastoma, the most common brain
tumor in
human adults.
Dr. Mack's research has focused primarily on the use of novel antitumor agents in
human estrogen receptor negative breast
tumor cells, and more recently, on the use of bioflavonoids in the regulation of estrogen receptor
positive (ER +) and estrogen receptor negative (ER --RRB- breast
tumor cell proliferation.
Phytates have been shown to inhibit the growth of
human leukemia
cells, colon cancer
cells, both estrogen receptor -
positive and negative breast cancer
cells, voicebox cancer, cervical cancer, prostate cancer, liver
tumors, pancreatic, melanoma, and muscle cancers.