Sentences with phrase «positive lysosomes»
Dmitry: as the paper itself notes, the most likely mechanism for the ability of hydroxypropyl - β - cyclodextrin to lower Aβ burden in the mouse model is AD finding is by normalizing membrane cholesterol content and reducing the appearance of abnormal cathepsin D - positive lysosomes, leading to reduced beta - secretase cleavage of APP and an upregulation of genes involved in cholesterol trafficking and Aβ clearance.
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A beta 42 first selectively accumulates in the perikaryon of pyramidal cells as discrete, granules that appear to be cathepsin D - positive, suggesting that they may represent lysosomes or lysosome - derived structures.