Sentences with phrase «positive nodal»

Not exact matches

Node - positive patients also had improved 10 - year rates of survival without metastasis and melanoma - free survival compared to those whose nodes were found to be positive on the nodal observation arm of the study.

Radiotherapy to the chest wall and regional lymph nodes (under the arm, above the collar bone and under the breast bone), known as regional nodal irradiation, is used after mastectomy in women with node - positive breast cancer who are treated with adjuvant systemic therapy.

Furthermore, SLN - positive patients who defer lymphadenectomy until clinically detected nodal recurrence may present with unresectable disease, representing a missed opportunity for regional disease control.

Consequently, until we have better ways of defining those patients who have been cured by SLN biopsy alone (or the long - term results of current prospective trials indicate otherwise), nodal observation should be chosen by SLN - positive patients only after very careful consideration, and not routinely recommended by surgeons or oncologists as a proven alternative to avoiding CLND.

The MSLT - 1 trial demonstrated that patients with a positive SLN undergoing CLND had far better melanoma - specific survival than those patients who manifested nodal recurrence either on the observation arm or after a false - negative SLN biopsy (10 - year melanoma - specific survival rates: 62.1 % vs 41.5 % and 34.4 %, respectively).

[6] In the MSLT - 1 trial, patients with isolated nodal recurrence had more total lymph nodes involved by melanoma than patients randomized to SLN biopsy who had a positive biopsy (all of whom were to have CLND; an average of 3.2 lymph nodes involved with metastatic melanoma vs only 1.4 positive nodes, respectively; P <.0001), [2] and were more likely to meet established criteria for adjuvant radiation, [7] which further increases the risk of postoperative lymphedema.