Sentences with phrase «positive tumors as»

These associations were primarily limited to hormone receptor — positive tumors as migraine was associated with a 0.65-fold (95 % CI, 0.51 - 0.83) reduced risk of estrogen receptor — positive (ER +) / progesterone receptor — positive (PR +) ductal carcinoma.

Not exact matches

Currently, many patients who acquire resistance to EGFR - targeted therapy undergo a tumor biopsy and are designated as either positive or negative for specific secondary mutations.

The trial investigated the drug in two separate cohorts of patients: Cohort A, which included 170 patients with heavily pretreated metastatic triple negative breast cancer (mTNBC) regardless of PD - L1 expression, and Cohort B, which included 52 patients with PD - L1 - positive tumors who received it as first - line therapy.

International researchers prospectively analyzed and compared tumor and matched plasma DNA for EGFR mutations from 1060 patients that were screened as part of a phase IV, open - label, single - arm, first - line gefitinib in EGFR mutation positive Caucasian patients.

Since estrogen receptor (ER) and progesterone receptor (PR) data were available and HER2 status was not, the researchers categorized the tumors as ER or PR positive (HR positive), or both ER and PR negative (HR negative).

The new technology was tested in mice for the ability to generate antibodies in their blood stream that would target human PSMA as well as target PSMA - positive tumors.

They also showed that drugs against a type of breast tumor called HER2 positive breast cancer — such as the dual ERBB2 / EGFR inhibitor lapatinib — potentially could benefit more patients than currently receive them, if analysis of the tumor proteins is taken into consideration.

The biopsy of his primary tumor pointed to treatment with anti-HER2 therapy (Herceptin), but tissue from the metastatic biopsy, as well as cfDNA analysis, was negative for HER2 and positive for anti-epidermal growth factor receptor (EGFR) therapy (ABT - 806).

Depending on characteristics such as how many tumor cells, blood vessel cells, and immune cells are touching each other, the tumor microenvironment can nearly triple the chance that a common type of breast cancer (estrogen - receptor positive / HER2 negative) that has reached the lymph nodes will also metastasize, Condeelis and colleagues showed in a 2014 study of 3,760 patients.

Breast cancers are classified as ER - positive or ER - negative according to whether tumors are found to contain estrogen receptors.

«Our results suggest that napabucasin might be an effective STAT3 inhibitor in patients with tumors positive for pSTAT3, and further investigation of napabucasin as monotherapy in advanced colorectal cancer is warranted in these patients,» wrote Derek J. Jonker, MD, of Ottawa Hospital Research Institute at the University of Ottawa, Canada, and colleagues.

In all negative tumors, occasional positive tumor cells or coexisting reactive lymphocytes were present and served as internal positive controls (arrows in C, right).

Consequently, these tumor samples were classified as oncogene - positive.

Our findings suggest that this is also true in breast cancer as EGFR inhibition blocked the hypoxic CSC effect in ER - α — positive tumors.

Although the differing effects of hypoxia reported here are in conflict with previously published data, where no contrasting effect was seen (18 — 20), our data was produced using 13 primary breast cancer samples, as well as established cell lines, and the opposing effects in hormone receptor — positive and negative tumors, measured using multiple in vitro and in vivo CSC assays, were consistent in all cases.

Possible modes of hierarchy alteration are suggested as increased self - renewal (a), dedifferentiation of early progenitor cells (b), and blocked proliferation (c) of ER - α — positive and negative tumors.

For example, proteins related to angiogenesis, the process through which new blood vessels form to ensure supply of oxygen and nutrients to a tissue such as a tumor, are found to be clearly associated to clinical outcome in HPV - positive samples.

The data presented in this article suggests that tumor subtype needs to be taken into account during treatment design as blocking angiogenesis and therefore increasing tumor hypoxia may be beneficial in the treatment of ER - α — negative breast cancer but could have catastrophic effects on ER - α — positive breast cancer.

Breast tumors that are HER2 positive — meaning that they have high levels of a protein called HER2 — often respond to targeted medications, sometimes known as «smart bombs,» like Herceptin.

As has been suspected by many in the natural health community for a while, research from the University of Illinois has confirmed that the concentration of soy isoflavone in supplements may help drive tumor growth in women with estrogen - receptor positive breast cancer.