Sentences with phrase «positive tumors in»

The conjugate, which they named «chemocoxib A,» reduced growth of COX - 2 positive tumors in mice by 50 percent, but didn't have any effect on tumors that didn't express the enzyme.

Not exact matches

And two years on, the heart tumors were «the only positive finding that we've been really able to have confidence in,» Bucher told reporters.

Patients in the trial had advanced NSCLC, and their tumors tested positive for PD - L1 levels of 50 % or more.

The targeted radiotherapy shrank tumors for 71 % of patients who had already failed standard chemotherapy, but these results came from a small trial that started with 30 patients and then added another 20 after positive data started rolling in.

While nivolumab improved survival rates in the overall study population, it appeared to be most successful in patients whose tumors were positive for the human papillomavirus (HPV).

Mutations in the gene BRAF are the most common mutation found in melanoma, with up to 50 percent of tumors testing positive for the mutations.

They identified ALK - positive mesotheliomas by immunohistochemistry; confirmed with fluorescence in situ hybridization; and performed targeted next - generation sequencing of tumor DNA and RNA to get a full picture of the exact genetic rearrangement underpinning the disease.

«Interestingly, we found that activity of pembrolizumab was seen in both PD - L1 - positive and - negative tumors.

The trial investigated the drug in two separate cohorts of patients: Cohort A, which included 170 patients with heavily pretreated metastatic triple negative breast cancer (mTNBC) regardless of PD - L1 expression, and Cohort B, which included 52 patients with PD - L1 - positive tumors who received it as first - line therapy.

International researchers prospectively analyzed and compared tumor and matched plasma DNA for EGFR mutations from 1060 patients that were screened as part of a phase IV, open - label, single - arm, first - line gefitinib in EGFR mutation positive Caucasian patients.

In the second study, researchers examined whether aspirin is associated with breast density, which is a widely accepted risk factor for both estrogen receptor minus (ER --RRB- and estrogen receptor positive (ER +) breast cancers, and can be a key factor in detecting tumors during routine mammogramIn the second study, researchers examined whether aspirin is associated with breast density, which is a widely accepted risk factor for both estrogen receptor minus (ER --RRB- and estrogen receptor positive (ER +) breast cancers, and can be a key factor in detecting tumors during routine mammogramin detecting tumors during routine mammograms.

Shah next plans to rationally combine the toxin - secreting stem cells with a number of different therapeutic stem cells developed by his team to further enhance their positive results in mouse models of glioblastoma, the most common brain tumor in human adults.

In the group that received targeted treatment for ALK - positive lung cancer, each category of tumor reduction was associated with corresponding gains in PFS and OIn the group that received targeted treatment for ALK - positive lung cancer, each category of tumor reduction was associated with corresponding gains in PFS and Oin PFS and OS.

Also, we know hormone receptive positive tumors are much more sensitive to radiation, which could explain why we found the survival benefit in this group of patients.»

«The result was an extensive inhibition of tumor growth and prevention of metastasis to the lung in HER2 - positive animal models of breast cancer,» notes Navasona Krishnan, Ph.D., a postdoctoral investigator in the Tonks lab who performed many of the experiments and is lead author on the paper reporting the results.

But tumor - only analyses offer up many «false positive» mutations that appear to contribute to cancer, but which actually show up elsewhere in an individual's healthy tissue, a new study finds.

In this study, researchers assessed the outcomes of 280 prostate cancer (Cap) patients, and reviewed the DNA «fingerprints» of each patient's tumor (using the patient's initial diagnostic core biopsy) to determine if gene copy number alterations (CNAs), or breaks in CFSs, were related to a less positive response to treatmenIn this study, researchers assessed the outcomes of 280 prostate cancer (Cap) patients, and reviewed the DNA «fingerprints» of each patient's tumor (using the patient's initial diagnostic core biopsy) to determine if gene copy number alterations (CNAs), or breaks in CFSs, were related to a less positive response to treatmenin CFSs, were related to a less positive response to treatment.

The researchers found that OTL38 accumulated in FRα - positive tumors and metastases, and enabled the surgeons to remove an additional 29 percent of malignant lesions (confirmed by pathological examination of the resected tumors) that could not be identified with naked eyes and / or palpation.

«We found an association between increased breast cancer recurrence in women with a primary breast cancer tumor that was positive for the IGF1 receptor, which is consistent with other studies,» said Emond.

In the featured article of The Journal of Nuclear Medicine's October issue, German researchers report on their recent clinical experience, which establishes a dosing regimen for actinium - 225 (225Ac)- labeled targeted alpha therapy of patients with prostate specific membrane antigen (PSMA)- positive tumors.

The new technology was tested in mice for the ability to generate antibodies in their blood stream that would target human PSMA as well as target PSMA - positive tumors.

But recent work shows that while these cancers lack estrogen receptors, progesterone receptors, and aren't driven by the gene HER2, up to a third of these tumors express the androgen receptor — clinical trials are underway to inhibit the androgen receptor in these tumors in much the same way that the drug Tamoxifen inhibits estrogen receptor in estrogen - receptor - positive breast cancers.

In fact, they saw that the genetics of the tumors that did not undergo LOH (LOH - negative) were significantly different than those that did undergo LOH (LOH - positive).

These five - year results demonstrate positive tumor control and disprove the misconception that short - course treatment will result in late - appearing, unacceptable toxicities.»

Such a positive survival rate is encouraging considering that historically conventional RT resulted in poor tumor control for patients with inoperable lung cancer.

In Nrk mutant mammary glands, dense clusters of ER alpha - positive mammary epithelial cells were sometimes observed at late stages of pregnancy, which may represent the «bud» of the breast tumor.

Overall, the pathologic complete response rate was lower among women with at least one PIK3CA mutation in their tumor compared with women without a PIK3CA mutation, but the effect was only significant among the group of women with HER2 - and hormone receptor - positive breast cancer.

The new test, which examines cancer - related DNA and proteins in the blood, yielded a positive result about 70 % of the time across eight common cancer types in more than 1000 patients whose tumors had not yet spread.

Of the 22 patients whose tumors successfully grafted, six died before data from the mice were available, but in 13 of the remaining 16 cases, there was a positive correlation between mouse and human results.2 In a second study, performed in collaboration with Manuel Hidalgo of the Spanish National Cancer Research Center, the team found that 6 of 13 patients with advanced solid tumors who were treated based on results from personalized PDX mice had partial tumor remissions, even in cases where genetic sequencing of the tumor showed no actionable mutationsin 13 of the remaining 16 cases, there was a positive correlation between mouse and human results.2 In a second study, performed in collaboration with Manuel Hidalgo of the Spanish National Cancer Research Center, the team found that 6 of 13 patients with advanced solid tumors who were treated based on results from personalized PDX mice had partial tumor remissions, even in cases where genetic sequencing of the tumor showed no actionable mutationsIn a second study, performed in collaboration with Manuel Hidalgo of the Spanish National Cancer Research Center, the team found that 6 of 13 patients with advanced solid tumors who were treated based on results from personalized PDX mice had partial tumor remissions, even in cases where genetic sequencing of the tumor showed no actionable mutationsin collaboration with Manuel Hidalgo of the Spanish National Cancer Research Center, the team found that 6 of 13 patients with advanced solid tumors who were treated based on results from personalized PDX mice had partial tumor remissions, even in cases where genetic sequencing of the tumor showed no actionable mutationsin cases where genetic sequencing of the tumor showed no actionable mutations.3

While this trial - s primary efficacy goals are to evaluate anti-tumor activity in PD - L1 positive tumors, preliminary exploration of antitumor activity will also be conducted in a subset of PD - L1 negative tumors based upon response observed in PD - L1 positive tumors or lymphoma in this trial.

Depending on characteristics such as how many tumor cells, blood vessel cells, and immune cells are touching each other, the tumor microenvironment can nearly triple the chance that a common type of breast cancer (estrogen - receptor positive / HER2 negative) that has reached the lymph nodes will also metastasize, Condeelis and colleagues showed in a 2014 study of 3,760 patients.

A Phase I / II Study of Pembrolizumab (MK - 3475) in Children with Advanced Melanoma or a PD - L1 Positive Advanced, Relapsed or Refractory Solid Tumor or Lymphoma

A Phase II Basket Study of the Oral TRK Inhibitor LOXO - 101 in Subjects with NTRK Fusion - Positive Tumors

The researchers tested whether stromal tumor infiltrating lymphocytes (TILs) and other immune cells might predict responses to therapy in a set of 30 HER2 - positive breast cancer tissues treated with TCHP (26 patients) or with TCH without pertuzumab (4 patients).

Activation of Mammalian Target of Rapamycin Signaling Pathway Contributes to Tumor Cell Survival in Anaplastic Lymphoma Kinase — Positive Anaplastic Large Cell Lymphoma

«Our results suggest that napabucasin might be an effective STAT3 inhibitor in patients with tumors positive for pSTAT3, and further investigation of napabucasin as monotherapy in advanced colorectal cancer is warranted in these patients,» wrote Derek J. Jonker, MD, of Ottawa Hospital Research Institute at the University of Ottawa, Canada, and colleagues.

In all negative tumors, occasional positive tumor cells or coexisting reactive lymphocytes were present and served as internal positive controls (arrows in C, rightIn all negative tumors, occasional positive tumor cells or coexisting reactive lymphocytes were present and served as internal positive controls (arrows in C, rightin C, right).

The authors looked at gene expression in a panel of 50 ERBB2 (Her2) positive breast tumors and found that this pattern held up: DNA hypomethylation is associated with decreased gene expression in breast cancer.

On the plus side, Aisner points out, testing via circulating tumor DNA returns very few false - positives — when a test discovers DNA with a cancer - causing genetic change, it is strong evidence that this alteration is, in fact, present in the patient's cancer.

eIF4E was strongly positive in 22 of 31 (71 %) tumors.

p - 4E - BP1 and total eIF4E were both positive in all 31 ALK + ALCL tumors examined, but the level of detection was variable.

«HER2 - positive, ER - positive tumors have molecular features distinct from those of HER2 - positive, ER - negative cancers, suggesting that the two types of tumors should be treated with differently tailored approaches,» wrote study authors led by Luca Gianni, MD, of San Raffaele Scientific Institute in Milan.

In patients who exhibited a positive response to TIL therapy, the researchers were able to use ddPCR technology to detect a transient peak in HPV cfDNA, a sign of tumor deatIn patients who exhibited a positive response to TIL therapy, the researchers were able to use ddPCR technology to detect a transient peak in HPV cfDNA, a sign of tumor deatin HPV cfDNA, a sign of tumor death.

Prognosis in Patients With Sentinel Node - Positive Melanoma Is Accurately Defined by the Combined Rotterdam Tumor Load and Dewar Topography Criteria.

In addition, ActD has been shown to mimic nutlin - 3 in the activation of p53 - dependent transcription, induction of a reversible protective growth arrest in normal cells, and enhancement of the activity of the chemotherapeutic drugs, melphalan and etoposide, resulting in apoptosis of p53 positive human tumor cells [14In addition, ActD has been shown to mimic nutlin - 3 in the activation of p53 - dependent transcription, induction of a reversible protective growth arrest in normal cells, and enhancement of the activity of the chemotherapeutic drugs, melphalan and etoposide, resulting in apoptosis of p53 positive human tumor cells [14in the activation of p53 - dependent transcription, induction of a reversible protective growth arrest in normal cells, and enhancement of the activity of the chemotherapeutic drugs, melphalan and etoposide, resulting in apoptosis of p53 positive human tumor cells [14in normal cells, and enhancement of the activity of the chemotherapeutic drugs, melphalan and etoposide, resulting in apoptosis of p53 positive human tumor cells [14in apoptosis of p53 positive human tumor cells [14].

Mar. 12, 2015 — Melanoma patients whose tumors test positive for mutations in the NRAS gene were more likely to benefit from new immunotherapy drugs, according to a new study led by Vanderbilt - Ingram Cancer Center (VICC) investigators.

Some are real, but Germline (probably under - sampled or missed in the Normal); most are simply false positives in the tumor.

Our findings suggest that this is also true in breast cancer as EGFR inhibition blocked the hypoxic CSC effect in ER - α — positive tumors.

Because of small sample size, the changes in tumor - initiating cell number were not significant (P > 0.05), but these data are supportive of the in vitro findings and suggest that hypoxia may have a positive effect on the tumor - initiating cell population in ER - α — positive breast cancers and a negative effect in ER - α — negative tumors.

Dr. Mack's research has focused primarily on the use of novel antitumor agents in human estrogen receptor negative breast tumor cells, and more recently, on the use of bioflavonoids in the regulation of estrogen receptor positive (ER +) and estrogen receptor negative (ER --RRB- breast tumor cell proliferation.