Sentences with phrase «positive tumors who»

The trial investigated the drug in two separate cohorts of patients: Cohort A, which included 170 patients with heavily pretreated metastatic triple negative breast cancer (mTNBC) regardless of PD - L1 expression, and Cohort B, which included 52 patients with PD - L1 - positive tumors who received it as first - line therapy.

Not exact matches

The targeted radiotherapy shrank tumors for 71 % of patients who had already failed standard chemotherapy, but these results came from a small trial that started with 30 patients and then added another 20 after positive data started rolling in.

Currently, many patients who acquire resistance to EGFR - targeted therapy undergo a tumor biopsy and are designated as either positive or negative for specific secondary mutations.

For those who test positive twice, the next step will be imaging to find the tumor.

«The result was an extensive inhibition of tumor growth and prevention of metastasis to the lung in HER2 - positive animal models of breast cancer,» notes Navasona Krishnan, Ph.D., a postdoctoral investigator in the Tonks lab who performed many of the experiments and is lead author on the paper reporting the results.

«The good news is that we discovered that a subset of patients who had both high tumor mutation burden and high PDL - 1 positive status did experience a significant benefit from immunotherapy,» says Carbone.

On the other hand, someone who has not smoked and presents with a tumor that turns out to be HPV - positive, «that person is expected to survive,» Gillison says.

Of the 22 patients whose tumors successfully grafted, six died before data from the mice were available, but in 13 of the remaining 16 cases, there was a positive correlation between mouse and human results.2 In a second study, performed in collaboration with Manuel Hidalgo of the Spanish National Cancer Research Center, the team found that 6 of 13 patients with advanced solid tumors who were treated based on results from personalized PDX mice had partial tumor remissions, even in cases where genetic sequencing of the tumor showed no actionable mutations.3

In patients who exhibited a positive response to TIL therapy, the researchers were able to use ddPCR technology to detect a transient peak in HPV cfDNA, a sign of tumor death.