Sentences with phrase «possible drug targets»
Murchison and her team found striking similarities in tissues of origin, genetics, cancel cell mutation, and possible drug targets.
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According to Sinclair, all of the mammalian SIRT genes (and their proteins) are possible drug targets for therapies aimed at extending life, as well as staving off age - related illnesses, such as Alzheimer's disease, cancers and metabolic disorders, like diabetes.
Pharmaceuticals company Bayer, for example, recently revealed that it fails to replicate about two - thirds of published studies identifying possible drug targets (Nature Reviews Drug Discovery, vol 10, p 712).
In humans, Neuropeptide Y functions similarly to sNPF and has been studied as a possible drug target for obesity treatment.
«In addition to a possible drug target, calcineurin underlies a very basic aspect of parasite biology.»
A new PNAS paper from geneticist Tamara Caspary's lab identifies a possible drug target in medulloblastoma, the most common pediatric brain tumor.
This has led to a change in direction in recent years, and the tangles are now receiving more attention as a possible drug target.
He's looking at a class of brain cells that, when coaxed, destroy neurons, thinking they might be a possible drug target.
Not exact matches
Ionis Pharmaceuticals» mission is to develop safe and effective RNA - targeting drugs for both rare and more prevalent diseases and providing those drugs to the broadest group of patients as quickly as possible.
Similarly, it may be possible to identify and validate new targets for drugs that would selectively kill tumor cells with a particular molecular context.
She dreams of what will someday be possible with targeted drugs that exploit the best aspects of the gastric bypass effect.
In principle, he says, a drug developed to target this receptor could stimulate the growth of new spines, with possible implications for altering libido in humans.
The discovery of the new drug target, the researchers noted, was made possible by something very unusual about UVA.
Although scientists are still probing how biglycan influences bone formation, the protein may prove an attractive target for possible osteoporosis drugs, says John Termine, a specialist on the disease at Lilly Research Laboratories in Indianapolis.
Eventually the promise of other drug targets, along with the possible side effects of targeting NPY, put a damper on the effort — until now.
A team at Rockefeller University and Rensselaer Polytechnic Institute is developing a system that would make it possible to remotely control biological targets in living animals — rapidly, without wires, implants or drugs.
This is important because it makes it possible to model almost any autoimmune disease, evaluate new drug therapies, and even identify novel targets in the emerging area of cancer immunotherapies.
«This new model speaks to how schizophrenia could arise before birth and identifies possible novel drug targets,» said Jerold Chun, a professor and member of the Dorris Neuroscience Center at TSRI who was senior author of the new study.
«Possible new target for future brain cancer drugs.»
A nanomachine is a tiny device of less than a micron (one millionth of a meter, or about four one - hundred - thousandths of an inch) in size that scientists hope will soon be able to carry out a variety of medical and research functions, such as the targeted delivery of anticancer drugs, more efficiently and quickly than is possible today.
They analyze huge chemical, biological and medical databases, alongside reams of scientific papers, far quicker than humanly possible, throwing up new biological targets and potential drugs.
If these could be targeted to tumours — by attaching them to antibodies that recognise cancer cells, for instance — it would then be possible to destroy the malignant cells» DNA using lower doses of radiation or drugs.
As new blockbuster drugs for large, general populations become harder to find — and as scientific advances make new biological approaches possible — prospective drugs that target smaller populations are getting more attention, says Dale Edgar, a research fellow and chief scientist of a sleep disorders research unit at Eli Lilly, based in Guildford, U.K.
«Since this gene has previously been identified as a target for the development of new drugs, in the future, it may be possible that early detection will facilitate better management of this disease.»
«This is a hint at how the brain works,» Wang said, «and although we're a long way off, something to inhibit this D1 receptor might be a possible therapeutic target for a drug to help people resist the urge to drink after a stroke.»
Technology has made it possible to synthesize increasingly targeted drugs.
«By looking at how well these drugs target hCA II in protonated, neutral and deprotonated states, we hoped to obtain insights that would make it possible to improve these medicines so they can better target enzymes linked to cancer.»
The research could help other scientists to use cryo - EM in structure - based drug design studies — in which researchers build the best possible drugs starting from a molecule which already binds to the active site of a target protein.
What makes them different, he said, is that the whole point of a drug is to have a very targeted effect from the lowest dose possible.
«MYCN is often seen only as a marker for a poor prognosis, but it's critical to the disease and is a possible target for new drugs.»
More patients are needed to clarify the possible correlation between the location of the mutation and disease severity, but understanding this relationship could be of great value in identifying molecules directly involved in clinical phenotypes and in providing new targets for drug discovery,» says Dr. Tohyama.
This work presents a possible new drug target for cancer and heart disease, and was published in the journal, Nature Communications, on 8 July 2016.
Where research uncovers possible mechanisms for disease, those working in drug discovery can use these data to develop novel diagnostic or monitoring tools, to develop therapies that address the biological pathways concerned, or to develop companion diagnostics to ensure that new — or existing — therapies are targeted at the correct subgroup of patients.
His lab is now further investigating how this happens in hopes of identifying possible cancer drug targets for tumors that arise in obesity.
With this method, it is possible to analyze huge volumes of data to discover new drug targets, which can lead to the development of effective cancer medications.
The discovery of the molecular switch, called KIT, that turns on the growth of GIST has made it possible to diagnose GIST, and has led to the development of specific drugs that target the growth of this cancer.
Lung cancer treatment is an evolving field of science, currently there are several pathways under investigation as a possible treatment target.1 - 3 Targeted treatment is currently considered to be more efficient compared to the non-specific cytotoxic drugs, however; the small number of patients identified with mutations, limit the application of these drugs.
«Now that we know the importance of Irx3,» Dr. Bruneau added, «We need to dig deeper to see if it's possible to use drug therapy to target any of the electrical - impulse pathways that Irx3 regulates with drug therapy.»
The new family of drugs to which HTTRx belongs, called ASO drugs, can theoretically be designed to target any protein, so it's possible that a future programme might involve SCA17.
Research suggests a possible specific target for drugs fighting the most common type of breast cancer.
It is now possible to design drugs that go right to the vulnerable target of a disorder, thanks to the research produced from the Human Genome Project.
Ahn concluded that synergy between the drug classes is possible but dependent on two unexpected factors: the location and strength of fusion inhibitor binding to the envelope protein and the level of coreceptor expressed on the target cell.
Those hits are especially important as they demonstrate possible prediction of repurposed drug targets.
By learning as much as possible about those unique changes, and developing specific drugs and therapies to target them, we at City of Hope believe many cancers can be defeated at the molecular level, often with fewer side effects compared to traditional chemotherapy and other treatments.
In particular, the AMA believes it is possible to isolate particular health issues (mental health conditions, alcohol and other drug use, substance abuse disorders, and cognitive disabilities are the focus of this report card) as among the most significant drivers of the imprisonment of Aboriginal and Torres Strait Islander peoples, and target them as health issues as a part of an integrated approach to also reduce imprisonment rates.