Their analysis identified a series of
possible small molecules that make economic sense and could be made by converting captured CO2.
Not exact matches
The
molecules of essential oils are
small so it's
possible that they may cross the placenta, which is why diluting them is very important.
The synthesis method developed in this work opens up
possible variations, such as cross-linking or chemical functionalization (adding atoms or
small molecules to the carbon nanothread that alter its function).
It is thereby
possible to see the extent to which the
small molecules have to bind together for the clumping effect on the protein to be set off.
If indole allows pathogenic bacteria to withstand antibiotics, it may be
possible to thwart drug resistance by blocking indole signaling with
small molecules, Collins says.
It may also be
possible, he adds, «to produce these factors synthetically or develop
small molecules that mimic the activity, but that takes much longer.»
«One of our experiments showed that bypassing Lin28a and directly activating mitochondrial metabolism with a
small -
molecule compound also had the effect of enhancing wound healing, suggesting that it could be
possible to use drugs to promote tissue repair in humans.»
According to Monk and Ackerman,
possible future work includes using the zebrafish model system as a drug - screening tool to search for
small molecules that may flip that switch.
To investigate a
possible new therapy to treat West Nile Virus disease, Kumar and her colleagues focused on a
small «interfering» RNA
molecule developed in her lab.
A partial list would include the Patterson function, isomorphous replacement, and anomalous scattering, which enabled the determination of organic structures; direct (i.e., purely computational) methods of phase determination, which enabled
small -
molecule crystallography to be almost totally automated; synchrotron radiation and area detectors, which together made it
possible to collect data on macromolecular structures in hours instead of months; and automatic interpretation of electron density maps.
«This tells us that it is
possible to design a
small -
molecule inhibitor that could powerfully disrupt the interaction between the toxin and the receptor,» said Brunger.
In addition, since two factors are sufficient for human iPS induction from NSCs, it may be
possible to substitute one or both of these factors with
small molecules that activate OCT3 / 4 or KLF4 gene expression.
Dr. King points out that a number of oral drug candidates inhibit PKC - delta and that it may be
possible to suppress PKC - delta production with microRNAs (
small RNA
molecules that help to regulate protein generation).
With the broad chemistry surrounding functionalized PEG used to create Hoechst derivatives, it may be
possible to target other therapies such as cells,
small molecules, and even nanoparticles.
«They tend to have
smaller molecules, which allows the actives to penetrate deeper into the skin where the can work as effectively as
possible,» explains Dr. Engelman.