If one could identify these molecules, they would yield information about both the basic biology of metastatic cancer and
possible therapeutic targets, and that is exactly what Quigley is trying to do.
If we can show that this anomaly doesn't occur in healthy cells, we will be able to think about exploring these structures as
possible therapeutic targets.»
With their new data in hand, the researchers are pursuing three
possible therapeutic targets to stop pancreatic cancer metastasis driven by annexin A2 and Sema3D.
«New cancer marker identified;
possible therapeutic target for breast cancer.»
«This is a hint at how the brain works,» Wang said, «and although we're a long way off, something to inhibit this D1 receptor might be
a possible therapeutic target for a drug to help people resist the urge to drink after a stroke.»
Not exact matches
These newly discovered molecular
targets will allow the development of
therapeutic strategies that may be explored as
possible routes to eliminate leukemic cells» resistance to chemotherapy.
«It is
possible that perhaps a
therapeutic agent
targeting BACE1 in humans might have a similar effect,» he says.
The researchers are now investigating the effects of these genes» mutations as
possible targets for new
therapeutic treatments.
«Our findings suggest that PRMT5 is a
possible prognostic factor and
therapeutic target for glioblastoma, and they provide a rationale for developing agents that
target PRMT5 in this deadly disease,» says co-corresponding author Robert A. Baiocchi, MD, PhD, associate professor of medicine and a hematologist at the OSUCCC — James who is also collaborating on an Ohio State effort to develop a PMRT5 inhibitor.
It is still too early to think about its clinical application, but the work reveals a new genetic
target on which to look for new
possible therapeutic strategies.
«The fact that HIV - infected macrophages can persist means that any
possible therapeutic intervention to eradicate HIV might have to
target two very different types of cells.»
Identifying miR - 211 as a
possible cause means the microRNA, and the genes it regulates, could be promising
therapeutic targets.