Maternal and early
postnatal immune activation produce dissociable effects on neurotransmission in mPFC - amygdala circuits Li Y, Missig G, Finger BC, Landino SM, Alexander AJ, Mokler EL, Robbins JO, Manasian Y, Kim W, Kim KS, McDougle CJ, Carlezon WA Jr., Bolshakov VY.
«The results are novel, as this sensitive and comprehensive testing has revealed how prenatal and early
postnatal immune activation may regulate core behavioral signs associated with ASD and certain other developmental disorders through changes in signal flow between different structural components of behavior - driving neural circuits,» said Bolshakov.
Not exact matches
To determine whether early
postnatal immune system
activation can produce these types of effects, McLean researchers treated mice with a lipopolysaccharide (LPS), a chemical that simulates a bacterial infection and causes a temporary (1 - 3 day)
activation of the
immune system.