Sentences with word «postsynaptic»
The term "postsynaptic" refers to the part of a neuron or brain cell that receives information or signals from another neuron. It is like the receiver that listens to messages from another cell. Full definition
In addition to the glutamate - secreting presynaptic neuron, the signal - receiving postsynaptic neuron and even the astrocyte itself may employ signaling molecules of their own to keep the system in balance, she said.
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The peptide selectively inhibits certain postsynaptic cells but not others and thereby allows the sensory neurons to achieve target - specific synaptic actions.
Within synapses, more specifically in areas of postsynaptic density (PSD), there is a high concentration of proteins that receive and transduce synaptic information.
Serotonin induces excitatory postsynaptic potentials in apical dendrites of neocortical pyramidal cells.
Slow - acting neurotransmitters control the efficacy of fast synaptic transmission by regulating the efficiency of neurotransmitter release from presynaptic terminals and by regulating the efficiency with which fast - acting neurotransmitters produce their effects on postsynaptic receptors.
A training procedure analogous to differential classical conditioning produces differential facilitation of excitatory postsynaptic potentials (EPSP's) in the neuronal circuit for the siphon withdrawal reflex in Aplysia.
SSRIs also indirectly down - regulate the 2A receptor on postsynaptic (receiving) neurons, which is also necessary for the drugs to work.
The most likely scenario, Shatz believed, was that the molecules sat on a neuron's postsynaptic terminals, where electrochemical signals from other neurons are received.
mThy1 - AS mice administered only control IgG1 suffered dendritic atrophy (as suggested by reduced staining with MAP2) and synaptic loss (evaluated with postsynaptic density - 95 (PSD - 95) and synaptophysin) across several regions of the brain, but this neurodegenerative damage was substantially prevented in mice administered 1H7, 5C1, or 9E4.
Title: De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia Author: G. Kirov et al..
Spinal cord sympathetic neurons are therefore called presynaptic (or preganglionic) neurons, while peripheral sympathetic neurons are called postsynaptic (or postganglionic) neurons.
The research group found impaired spine development and decreased miniature excitatory postsynaptic current frequency and amplitude in ARHGAP33 KO mice.
Berg LK, Larsson M, Morland C, Gundersen V (2013) Pre - and postsynaptic localization of NMDA receptor subunits at hippocampal mossy fibre synapses Neuroscience, 230, 139 - 50 PubMed 23159309
Flex vectors expressing fluorescent cytoplasmic markers (e.g. eYFP) and synaptic proteins (e.g. postsynaptic PSD95 - mcherry) are used in high concentrations in combination with low concentrations of vectors expressing the required recombinase.
These structural changes depend on an interaction of the presynaptic neuron with an appropriate postsynaptic target.
Consistent with recent studies of such changes, we find that long - lasting potentiation of synaptic transmission between cultured hippocampal neurons is accompanied by an increase in the number of clusters of postsynaptic glutamate receptors containing the subunit GluR1.
At each synapse, a presynaptic neuron sends chemical signals to one or more postsynaptic receiving cells.
At synapses between cortical pyramidal neurons and principal striatal medium spiny neurons (MSNs), postsynaptic D1 and D2 dopamine (DA) receptors are postulated to be necessary for the induction of long - term potentiation and depression, respectively — forms of plasticity thought to underlie associative learning.
The same transmitter, acetylcholine, can independently stimulate both a chloride ion conductance and a sodium pump mechanism in the same follower cell by acting on two different postsynaptic receptors.
Postsynaptic P2 × 3 - containing receptors in gustatory nerve fibres mediate responses to all taste qualities in mice
The main postsynaptic density protein at inhibitory synapse is gephyrin.
Finally, we examined LTP at corticostriatal synapses in 6 - month old mice using a Hebbian protocol consisting of 4 trains of 100 Hz presynaptic stimulation paired with postsynaptic depolarization.
Furthermore, it will be interesting to investigate whether pre - or postsynaptic mechanisms around a given «hotspot» region determine the rate of turnover, and how precisely clustered synapses are formed and stabilized.
«We found that, during periods of recurrent network activity, cortical pyramidal cells in vivo and in vitro receive strong barrages of both excitatory and inhibitory postsynaptic potentials, with the inhibitory potentials synchronously controlling the timing of action potentials.»
«Most drugs for treating neurological diseases affect postsynaptic signaling,» says Brunger.
Here, we can now visualize and manipulate pre - and postsynaptic elements involved in learning.
Involved in cannabinoid - dependent depolarization - induced suppression of inhibition (DSI), a process in which depolarization of CA1 postsynaptic pyramidal neurons mobilizes eCBs, which retrogradely activate presynaptic CB1 receptors, transiently decreasing GABAergic inhibitory neurotransmission (PubMed: 22388959).
Postsynaptic ERG potassium channels limit muscle excitability to allow distinct egg - laying behavior states in Caenorhabditis elegans.
After this induction period, miniature excitatory postsynaptic AMPA - R currents (mEPSCs) were recorded from DA neurons, which could be isolated by blocking inhibitory GABA - Rs and voltage gated sodium channels.
In addition, the relative roles of presynaptic and postsynaptic NMDA - Rs has been extensively analyzed in brain slices (Corlew et al., 2008; Rodriguez - Moreno and Paulsen, 2008), which PLE / CM - MK 801 may facilitate because it offers a new method for selectively blocking NMDA - Rs in defined subpopulations of neurons.
A small percentage of ASD patients carry mutations in genes encoding neuroligins, which are postsynaptic cell - adhesion molecules.
At the synapse, the neuron releases neurotransmitters that flow into another, postsynaptic neuron, which then fires too.
The detectable phosphodiesterase activity was localized in postsynaptic (dendritic) nerve endings, most of it immediately adjacent to the synaptic membrane.