Sentences with phrase «posttranslational modifications»

Daniel Lohmann (Thiele, MPG)-- «Posttranslational modifications of Ancient Ubiquitous Protein 1 control intracellular Lipid Droplet clustering» (2013)

In biological systems in particular, this scale ‐ free addition of new nodes is likely a consequence of gene duplication (Qian et al, 2001), and is also affected by alternate splicing and posttranslational modification in protein networks (Qian et al, 2001; Bhan et al, 2002; Pastor ‐ Satorras et al, 2003; Vazquez et al, 2003), as well as the variable chemical versatility of the metabolic intermediates in metabolic networks.

Glycosylation is among the most abundant and diverse protein posttranslational modifications, regulating important cellular processes such as protein folding and cell - cell interactions.

Nicholas Tonks Posttranslational modification; phosphorylation; phosphatases; signal transduction; protein structure and function

Immunoprecipitation (IP), mass spectrometry (MS), co-immunoprecipitation (Co-IP) and / or affinity purification investigate more aspects including posttranslational modifications (PTMs), DNA... — Read more

While SIRT1 and 2 inhibit NF - kB through posttranslational modification, SIRT6 neutralizes it by decreasing the accessibility of p65 subunit on promoter region of NF - kB target genes 32.

This text covers topics ranging from plant genome structure and the key control points in how genes are expressed, to the mechanisms by which proteins are generated and how their activities are controlled and altered by posttranslational modifications.

Posttranslational modification of histones is one way that the cell regulates the packing and unpacking of chromatin, which in turn helps to determine whether a gene is activated or repressed.

Symposia III: Mechanisms Behind Adaptations to Physical Activity / Inactivity The session will focus on signaling pathways, gene expression and posttranslational modifications in skeletal muscle remodeling and adaptation in activity and inactivity.

In collaboration with the University of Texas Southwestern Medical Center (UTSW) in Dallas, the researchers found that the tumor - suppressive activity of geranylgeraniol was accompanied by down - regulation of HMG CoA reductase, a key enzyme in the mevalonate pathway that provides essential intermediates for the posttranslational modification of growth - related proteins such as Ras, nuclear lamins and insulin - like growth factor receptors.

Environmental factors interact with the different subgenomes to modify the transcription of their component genes and to modulate the translation of protein products and their posttranslational modification, yielding changes in protein and cellular function and metabolism, and defining an intermediate phenotype.

Importantly, these pathways can be targeted with drugs to inhibit the enzyme responsible for depositing the posttranslational modifications that facilitate many of these interactions.

CaaX processing is a posttranslational modification of the carboxyl - terminus of more than one hundred proteins in eukaryotes that are essential for growth, development and survival.

Both of these posttranslational modifications can disrupt FP folding rendering the protein non-fluorescent.

We will use as an example the quantification of tubulin polyglycylation in wild - type testes and in Bug22 mutant testes, which present defects in the deposition of this posttranslational modification.

Genetically encoded biosensors are a class of GFP - based probes that report on protein activities, posttranslational modifications, conformational changes or other molecular processes.