Sentences with phrase «potent small molecule inhibitor»

We discovered a potent small molecule inhibitor of furin which has proven useful both in bacterial diseases where furin activation is critical to toxin activation as well as in cancer pathogenesis.

Not exact matches

A panel of small molecules that inhibit Zika virus infection, including one that stands out as a potent inhibitor of Zika viral entry into relevant human cell types, was discovered by researchers from the Perelman School of Medicine at the University of Pennsylvania.

This lab, in collaboration with the lab of Ruben Shaw at the Salk Institute, recently identified SBI - 0206965, the first potent and selective small molecule inhibitor of ULK1, a serine / threonine kinase that is a critical regulator of autophagy.

Using Chemotype Evolution, Carmot has identified potent small molecule and peptide - small molecule hybrid inhibitors.

More recently, the team published the structure of Eis in complex with two potent inhibitors they'd discovered using high - throughput screening of approximately 123,000 small molecules.