The remaining gaps in our understanding of the biology of gene drives and
the potential effects of gene - drive modified organisms on the environment are fundamental considerations in the development and release of gene - drive modified organisms, the report says.
Not exact matches
Because
gene drives can pass such changes down from one generation to the next, each
potential alteration in the code
of life could have a lasting and unknowable
effect.
«Identifying which
of these candidate
genes actually causes variation in responses to cold snaps will give us the
potential to understand whether evolution to climate change can occur in both wild and domesticated animals, allowing us to better predict which species or breeds will be «winners» and «losers» and to better mitigate the
effects of anthropogenic climate change on a wide range
of organisms from beneficial pollinators to invasive pests,» said Theodore Morgan an associate professor
of evolutionary genetics in the Division
of Biology at Kansas State University and senior author
of the study.
In addition, he and his team are using their CRISPR / Cas9 DNA - editing platform to study the
effects of deleting other
potential malaria host - factor
genes and to learn more about the roles
of these host factors in mosquitoes.
Their research team currently is testing the
potential effect of the unique differences
of the giraffe's FGFRL1
gene by introducing these changes into mice using the new CRISPR
gene - editing methods.
Dr. Martinez - Agosto noted, «Looking at the functionality
of these
genes and their
effect on the immune response has great
potential for accelerating the development
of new targeted therapies.»
The study identified several other
potential colitis
genes, he added, and this particular one's
effect on the barrier cells» energy requirements suggests a new category
of mutations with the
potential to cause IBD.
Corn plants outfitted with the
gene tolerated six times the concentration
of glyphosate that farmers normally apply, with no apparent
effect on health or reproduction — more than enough for commercial
potential, says Verdia's Linda Castle.
Güler added, «If we can use
gene therapy to exert control over neurons, the
potential exists to modify or eliminate the
effects of certain neurological diseases by controlling ill - firing neural networks.
The report finds that the current regulatory practices for assessing risks or
potential environmental
effects of field experiments or planned releases are inadequate for
gene drives.
Using a variation
of CRISPR,
gene editing may be a
potential strategy for mimicking the protective
effects of a genetic mutation linked to heart disease.
ANN ARBOR, Mich. — A new study suggests a
potential new way to block one
of the most common cancer - causing
genes, without causing severe side
effects.
Recently, exceptional environmental releases
of antibiotics have been documented, but the
effects on the promotion
of resistance
genes and the
potential for horizontal
gene transfer have yet received limited attention.
These
potential problems were rapidly addressed by others who found that chemical modifications
of the siRNA sugar backbone could block most off - target
effects without jeopardizing
gene knockdown.
«Dark chocolate, a high source
of polyphenols, and flavanols in particular, has lately received attention for its possible role in modulating obesity because
of its
potential effect on fat and carbohydrate metabolism, as well as on satiety... The research undertaken to date has shown promising results, with the possible implication
of cocoa / dark chocolate in the modulation
of obesity and body weight through several mechanisms including decreasing the expression
of genes involved in fatty acid synthesis, reducing the digestion and absorption
of fats and carbohydrates and increasing satiety.»
Although the thermogenic
effect of CCRT has the
potential to produce significant
effects on these metabolic targets as well as on fat absorption and energy intake, possibly via its impact on the gut microbiota and
gene expression, a clinically meaningful outcome also depends on compliance by the subjects.
Polygenic risk scores could be useful to stratify the risk
of several cancers among patients in medical centers, allowing for the
potential discovery
of new associations between
genes, disease and secondary
effects, according...
... According to a review by Lovich and Ennen (2013), the construction and operation
of wind farms have both
potential and known impacts on terrestrial vertebrates, such as: (i) increase in direct mortality due to traffic collisions; (ii) destruction and modification
of the habitat, including road development, habitat fragmentation and barriers to
gene flow; (iii) noise
effects, visual impacts, vibration and shadow flicker
effects from turbines; (iv) electromagnetic field generation; (v) macro and microclimate change; (vi) predator attraction; and (vii) increase in fire risks.
At the same time, FWS recognizes that it has not evaluated the
potential long - term
effects of big renewable energy projects that fragment or isolate desert tortoise conservation areas, possibly «cutting off
gene flow between these areas.»