Sentences with phrase «potential gene targets»

Dr George Vassiliou, joint project leader from the Sanger Institute and Consultant Haematologist at Cambridge University Hospitals NHS Trust, said: «This research has led to the identification of many potential gene targets for future AML therapy, which we are making available to other researchers to explore.

Not exact matches

To generate a rich source of potential vaccine and drug target candidates, the team identified a set of genes that are more active in certain stages of the parasite life cycle and within the parasite's gut.

The study, published online today in Science Translational Medicine, further points to a master switch for these gene sets as a potential target of future therapies.

«Neuroscientists are using these new gene - editing and molecular tools to develop potential therapeutic targets across multiple disease fronts.»

Moreover, researchers have already developed a potential therapy that targets the gene's protein.

The same process has been studied as a potential genetic therapy for more than a decade, because you can target any disease gene with matching dsRNA.

«Such changes may affect other genes as well; we haven't studied all the potential targets yet.

Despite this new direction for identifying targets for pharmaceutical interventions against RP, the researchers underscore that gene therapy still has great potential and possible benefits, and they are actively pursuing efforts with this approach for several forms of RP.

«Gene defect as a potential gateway for targeted prostate cancer therapy.»

Further investigation uncovered CHD1's role as vital to PTEN signaling, and as a potential therapeutic target in prostate and breast cancers with PTEN gene loss.

«A retrospective analysis of the CHD1 gene in these samples may reveal the potential utility of CHD1 as a biomarker for improved prostate cancer patient stratification and targeted therapy with PARP inhibitors,» notes Johnsen.

Still, the standard form of liver - targeted gene therapy carries a range of potential complications, including the risk of harmful mutations and of the body mounting an immune response against the viral vectors used to carry the correct forms of the defective genes responsible for haemophilia.

One potential treatment for CF is gene therapy, and a major challenge in gene therapy is packaging replacement genes so they can be delivered to the target cells.

Significant binding by miR -124-3p to two of the potential target genes was seen, as measured from immunoprecipitated RNA - induced silencing complexes.

Genes that increase risk for AD are potential targets for new disease - modifying AD drug therapies.

Four of these potential target genes were significantly down - regulated in the prefrontal cortex of corticosterone - treated rats, and this down - regulation inversely correlated with miR -124-3p levels.

In post-mortem brains of 15 controls and 15 MDD subjects, the MDD group showed significant increase in the expression of miR -124-3p, and expression of three of the potential target genes was significantly lower.

Identified eight highly potential target genes for binding by miR -124-3p, genes whose function is also reported to be critical in brain physiology during stress and MDD pathogenesis.

«We don't know exactly how the mutant Huntingtin gene causes the disease, so the idea is that targeting the gene expression cuts off the problem at its source — preventing it from ever having the potential to act,» said Dr Isalan.

Dr. Martinez - Agosto noted, «Looking at the functionality of these genes and their effect on the immune response has great potential for accelerating the development of new targeted therapies.»

By targeting the fundamental DNA of the gene, the zinc finger therapy also has the advantage over other potential Huntington's therapies of needing less frequent treatments.

Professor Moffatt said: «The genes we identified represent new potential drug targets for allergic diseases as well as biomarkers that may predict which patients will respond to existing expensive therapies.»

These include Cenix Bioscience, which has developed a new lab technique to identify the genes that are involved in cell division, predicted to be very useful for finding potential new targets for anticancer drugs.

Research fields are diverse, including basic research on cell proliferation, analysis of tumour cells and tissues to detect gene mutations, and identification of potential therapeutic targets in cancer.

«Our systematic screen offers an important first step toward the comprehensive identification of all miRNAs and their potential targets that serve in gene networks important for normal learning and memory,» said Ron Davis, chair of TSRI's Department of Neuroscience who led the study.

The dual - effect risk loci also include the region covering the gene FABP4, which is already being investigated for its potential as a diabetes and heart - disease drug target.

Twenty percent of the dependencies the team discovered were associated with genes previously identified as potential drug targets.

This common genetic heritage is a potential achilles heel of the metastases, however, many of these shared mutations are in tumor suppressor genes and our approach to therapeutically targeting these needs to be prioritised.

In research published today in Cell Reports, the team identify a large number of genes that could serve as potential targets for anti-AML treatments and describe how inhibition of one of these genes, KAT2A, destroys AML cells without harming non-leukaemic blood cells.

Whilst the gene needs to be studied in greater depth to understand its potential for use in the clinic, we show that targeting KAT2A destroyed AML cells in the laboratory while sparing healthy blood cells.»

To understand the functional role of miR - 7 in CSCs, we first searched its potential target genes that may be involved in stem cell physiology using multiple database including TargetScan, PicTar, miRanda, and SLOAN - Kettering.

We found that KLF4, which is one of the IPS genes, is among the highest scored genes on the target list and that there are 2 potential miR7 target sites in 3 ′ UTR region of this gene.

Her work - published in December 2007 - revealed genes involved in drug resistance and in evading the immune system, giving researchers potential targets for new therapies and vaccines.

However, like most gene transfer approaches a major concern with ZFN technology is the potential for oncogenesis due to off - target effects.

First author Dr Reza Haqshenas said the researchers then used gene silencing technology to determine whether the genes» cell factors identified using the antibody microarray were indeed important for HCV replication and therefore potential targets for anti-HCV compounds.

This study is good example of a precision medicine themed approach to showing how a mechanistic understanding of the differential gene expression can yield biomarkers that can be used for early detection of disease, as well as potential therapeutic targets.

GOMiner — To provide additional statistical stringency to the identification of potential targets, we then analyzed the data sets generated by the SAM - RS analysis of the microarray data for hypoxia - associated coregulation of multiple, functionally related genes.

The scientists analyzed 479 cancer genes to determine which ones were potential targets for medications.

Thus, neural derivatives of disease - specific human pluripotent stem cells constitute a relevant biological resource for exploring the impact of adult - onset HD mutations of the HTT gene on the division of neural progenitors, with potential applications in HD drug discovery targeting HTT - dynein - p150Glued complex interactions.

We know that regeneration is an orchestra of communication signals from a number of different tissues, and those tissues have to turn on genetic light switches at the same time, so part of the challenge in defining those circuits in greater detail is going to be interrogating these miRNAs and their potential target genes in a mammalian system.

This is a great example of a potential gene therapy target that still needs a fair amount of work to validate the thesis and the initial data, but having a large number of existing human carriers is a good sign on the safety front.

With scientists learning more about the potential of CRISPR as a tool for gene - editing, it is now becoming increasingly possible to develop better forms of treatment that can target specific malignancies in the body.

PrediXcan has the potential to identify gene targets for therapeutic applications faster and with greater accuracy than traditional methods.

Of these, SLC24A4 and CACNA1H are potential candidate genes for BP regulation, and the latter is a drug target for a class of calcium channel blockers.

Tuesday morning, even as the scientists gathered at the National Academy, news broke from the journal Science that researchers at the Broad Institute, Harvard University and M.I.T. have come up with a new way to use CRISPR that reduces the potential for off - target gene - snipping.

We furthermore identified a conservative set of 125 potential domestication targets using four complementary scans for genes that have undergone positive selection.

Horizontal transfer of genes of bacterial origin has contributed to some of the metabolic differences in these parasites, and a number of novel potential drug targets have been identified.

By comparing all of the genes that are active in disease and normal tissue, one can get valuable information on new pathways and potential therapeutic targets.

There are a few reasons to target different regions of the gene with multiple gRNAs, but the most important is that you could avoid potential off target artifacts by comparing the phenotypes of multiple gRNAs.

Their contributions to the yeast community include physical mapping methods, synthetic lethality screen approaches for identifying cross-species candidate genes as potential cancer drug targets, and a widely used set of vectors and yeast host strains that have been instrumental in work that has led to countless discoveries in recent decades.