Sentences with phrase «potential in embryonic stem cells»

Research led by the Babraham Institute with collaborators in the UK, Canada and Japan has revealed a new understanding of how an open genome structure supports the long - term and unrestricted developmental potential in embryonic stem cells.

Not exact matches

«We've shown that SIF - seq can be used to identify enhancers active in cardiomyocytes, neural progenitor cells, and embryonic stem cells, and we think that it has the potential to be expanded for use in a much wider variety of cell types,» Dickel says.

Starting in 2007, in the same French Institute of Health and Medical Research (INSERM) lab where he did his Ph.D., Catelain worked to harness the potential of embryonic stem cells for treating cardiac diseases.

«Perhaps there are some mammary gland stem cells that can be coaxed to have a slightly broader potential than normal, but I very much doubt that embryonic - like cells normally exist in the breast,» says Robin Lovell - Badge of the National Institute for Medical Research in London.

Research involving the derivation and use of embryonic stem (ES) cells is permissible only where there is strong scientific merit in, and potential medical benefit from, such research.

In this way they act like embryonic stem cells and share their revolutionary therapeutic potential — and as such, they could eliminate the need for using and then destroying human embryos.

In addition to providing an alternative to embryonic stem cells for potential use in regenerating diseased tissues, iPS cells are being used to learn more about diseases, especially diseases driven by mutated geneIn addition to providing an alternative to embryonic stem cells for potential use in regenerating diseased tissues, iPS cells are being used to learn more about diseases, especially diseases driven by mutated genein regenerating diseased tissues, iPS cells are being used to learn more about diseases, especially diseases driven by mutated genes.

The results help fill in the scientific puzzle kicked off by Dolly's cloning, which proved that mammalian egg cells were capable of dissolving the genetic roadblocks that limit the potential of most adult cells to give rise to only a single type of tissue — that of the organ from which they hail — whereas embryonic stem cells have the potential to become virtually any kind of body tissue.

«That started a lot of excitement that there might be these adult stem cells that had the potential of embryonic stem cells,» says stem cell researcher Amy Wagers of the Joslin Diabetes Center in Boston.

The findings are reported in the article «A Sox2 distal enhancer cluster regulates embryonic stem cell differentiation potential» published online December 15 in Genes & Development.

In their experiments, about 20 percent of embryonic stem cells lacking the microRNA exhibited expanded fate potential.

By contrast, most embryonic and induced pluripotent stem cells are more restricted in their developmental potential, able to form embryonic cell types, but not extra-embryonic tissues.

Embryonic stem cells have the potential to develop into any cell type in the body, and many scientists would like to discover how to use them to treat intractable diseases such as diabetes or Parkinson's disease.

John Gearhart, a stem cell researcher at Johns Hopkins University in Baltimore, Maryland, says the study «appears to be the best so far» at offering a potential alternative to human embryonic stem cells.

Other potential uses of embryonic stem cells include investigation of early human development, study of genetic disease and as in vitro systems for toxicology testing.

However, it would be unwise to ignore the potential for either adult or embryonic stem cells to result in a meaningful new approach.

This information could then be used to prompt embryonic stem cells to differentiate in the culture dish into neurons for potential use in cell - replacement therapy.

My post-doctoral work on the identification of genes required for normal germ line development and fertility led to the discovery that the germ line is exquisitely sensitive to mutations in components of the mitotic spindle that have the potential to lead to aneuploidy — this sensitivity may also extend to embryonic and adult stem cells.

Furthermore, stem cells with perhaps even greater potential for therapeutic purposes are present in and retrievable from blastocytes â $» embryonic stem cells â $» and understandably, a heated debate about their use has developed.

Critical issues include: (i) heterogeneity in stem cell populations (ii) regulation of cell fate choices; (iii) declining tissue performance with age and exposure to environmental injuries; (iv) the use of iPS and Embryonic Stem (ES) cells, and reprogramming methods for phenotyping disease states and potential use of these stem cells in the clistem cell populations (ii) regulation of cell fate choices; (iii) declining tissue performance with age and exposure to environmental injuries; (iv) the use of iPS and Embryonic Stem (ES) cells, and reprogramming methods for phenotyping disease states and potential use of these stem cells in the cliStem (ES) cells, and reprogramming methods for phenotyping disease states and potential use of these stem cells in the clistem cells in the clinic.

Unlike embryonic stem cells, which are developmental blank slates that can generate virtually all types of cells found in adult humans, adult stem cells are thought to possess limited potential to transform into cells found in their tissues of origin.

Virtually identical to human embryonic stem cells (hESCs) except for their origin of isolation, the recently created induced pluripotent stem cells (iPSCs)(Yu et al., 2007; Takahashi et al., 2007) hold much potential for use in regenerative therapies.

Embryonic stem (ES) cells are special cells that have the potential to form any tissue in the body.

In a bid to harness the potential of embryonic stem cells, surgeons in California have implanted lab - grown retinal cells into the eyes of two patients going blind from macular degeneratioIn a bid to harness the potential of embryonic stem cells, surgeons in California have implanted lab - grown retinal cells into the eyes of two patients going blind from macular degeneratioin California have implanted lab - grown retinal cells into the eyes of two patients going blind from macular degeneration.

Both mouse and human iPSCs are similar to embryonic stem cells (ESCs) with respect to their morphology, cell behavior, gene expression, epigenetic status and differentiation potential both in culture and in vivo.

Using cloning technology to derive embryonic stem cells genetically identical to a patient is potentially very important, not only to provide a source of cells that may be used to cure patients, but also to allow for genetic disease to be studied and potential drug treatments to be explored in the laboratory.

The authors highlight the successful application of both induced pluripotent stem cells and embryonic stem cells for this first example of the in vitro formation of functional and mature skeletal muscle tissue, thereby also establishing the potential for patient - specificity in disease modeling, drug development, and possible muscle repair.

Embryonic stem cells and iPS cells can be grown in large number in the laboratory and have the potential to be coaxed into becoming any cell type in the body, including glucose sensing, insulin - producing beta cells.

His pioneering mouse embryonic stem (ES) cell work in the 1980s, demonstrating germ - line transmission and the great potential of ES cells to generate mice carrying mutations in endogenous genes, established milestones in a field that saw the award of the 2007 Nobel Prize in Physiology or Medicine to Mario Capecchi, Martin Evans, and Oliver Smithies.