Sentences with phrase «potential targeted therapy»
Routine molecular profiling for BRAF and KIT is recommended and may identify potential targeted therapy options.
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«Potential targeted therapy for lung cancer identified using fly model.»
«This provides a rationale for a potential targeted therapy for this specific subtype of JMML,» said Weiss.
Interpretation of genome sequencing data is a significant challenge because of the volume of genomic data to sift through, as well as the large, growing body of research on molecular drivers of cancer and potential targeted therapies.
These findings suggest that specific MFN2 mutations cause tissue - selective mitochondrial dysfunction with increased adipocyte proliferation and survival, confirm a novel form of excess adiposity with paradoxical suppression of leptin expression, and suggest potential targeted therapies.
Not exact matches
What Stephen Hawking Missed: Small Biotechs Developing Promising Cell Therapies for Devastating Disease Source: Streetwise Reports (5/2/18) In the second of a two - part series exploring the disruptive cell therapy space, Maxim Group analyst Jason McCarthy takes a look at small - cap companies targeting big - ticket indications and their potential to drive blockbuster value for both patients and investors.
Drugs that target VCP are already being developed as potential therapies for cancer.
«The most exciting result is the discovery of PGC1 - alpha as potential new target of therapy for early intervention Scherzer,» says.
«By identifying key molecular drivers within these networks, we have been able to determine potential therapeutic targets that could help us to develop the first pharmacological therapy for CAVD.»
The study, published online today in Science Translational Medicine, further points to a master switch for these gene sets as a potential target of future therapies.
Researchers are also exploring a potential new therapy that could target H3K27me3 and reverse the lowered levels.
The current study was designed to clarify the cellular hierarchy underlying glioblastoma, to identify epigenetic factors that distinguish glioblastoma stem cells from more differentiated tumor cells and to suggest potential therapies targeting those factors.
Understanding these mechanisms may provide a potential target for future therapies to address sensory symptoms, both through pharmacological and behavioral interventions,» the researchers wrote.
Investigations aimed at determining the downstream targets of LIF would help to clarify the functional importance of LIF in muscle regeneration, and further its potential application in cell transplantation therapy.»
Moreover, researchers have already developed a potential therapy that targets the gene's protein.
A new wave of potential immune therapies aims to target the network of complex sugars that coat cancer cells, Esther Landhuis reported in «Cancer's sweet cloak» (SN: 4/1/17, p. 24).
«International study of advanced prostate cancer genome finds potential targets for drug therapy.»
«We are looking to optimize the combinations of targeted therapies and the scheduling of those therapies so we can improve tumor shrinkage and minimize potential toxicities for a patient,» said Andrew Aplin, PhD, Associate Director for Basic Research and the Program Leader for Cancer Cell Biology and Signaling (CCBS) in the NCI - designated Sidney Kimmel Cancer Center at Jefferson Health.
The research was published in the scientific journal Nature Genetics this week and scientists hope it will provide another potential target for therapy development.
«Thanks to a deeper understanding of cancer biology, we have a potential new targeted therapy for multiple myeloma, and can better tailor treatment for kids with Wilms tumor.
Based on a report published on August 20, 2015 in Nature Communications, it has been established that certain nutrients support CML stem cell activity in vivo, thus pointing towards a potential therapeutic target for CML therapy.
The same process has been studied as a potential genetic therapy for more than a decade, because you can target any disease gene with matching dsRNA.
Despite this new direction for identifying targets for pharmaceutical interventions against RP, the researchers underscore that gene therapy still has great potential and possible benefits, and they are actively pursuing efforts with this approach for several forms of RP.
The depth and breadth of information obtained is promoting biomarker discovery, especially potential targets for drug therapies, as well as possibly enabling improved patient stratification for clinical trials and treatment protocols.
The phase I and phase I / II trials aimed to measure the safety of adding HCQ to either chemotherapy, radiation therapy or targeted therapies, its effectiveness at inhibiting autophagy, and the potential clinical benefit of HCQ combination therapies.
«Gene defect as a potential gateway for targeted prostate cancer therapy.»
On the flipside, targeting this growth factor or BCL - 2 could reduce NK cell numbers and offer potential therapies for immune disorders such as some types of autoimmune diseases, sepsis or graft versus host disease, a side effect of bone marrow transplants.
«A retrospective analysis of the CHD1 gene in these samples may reveal the potential utility of CHD1 as a biomarker for improved prostate cancer patient stratification and targeted therapy with PARP inhibitors,» notes Johnsen.
Still, the standard form of liver - targeted gene therapy carries a range of potential complications, including the risk of harmful mutations and of the body mounting an immune response against the viral vectors used to carry the correct forms of the defective genes responsible for haemophilia.
By tracking and understanding which host cell pathways are manipulated by these T. gondii proteins, scientists can identify potential new targets to develop more effective therapies against highly aggressive solid tumors.
One potential treatment for CF is gene therapy, and a major challenge in gene therapy is packaging replacement genes so they can be delivered to the target cells.
The review, titled «Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential,» covers the strengths and weaknesses of the two forms of therapy and notes how their combination could be particularly Therapy: Toward Combination Strategies with Curative Potential,» covers the strengths and weaknesses of the two forms of therapy and notes how their combination could be particularly therapy and notes how their combination could be particularly potent.
«Review highlights potential of cancer immunotherapy plus targeted therapy.»
Genes that increase risk for AD are potential targets for new disease - modifying AD drug therapies.
«People have been targeting telomerase as a potential cancer therapy for a long time,» he says, noting that anti-telomerase drugs are in phase II clinical trials against several cancers.
They suggest allocating greater resources to research focused on immune checkpoint therapies and targeted / immunotherapy combination therapies with «curative potential.»
Dr. Martinez - Agosto noted, «Looking at the functionality of these genes and their effect on the immune response has great potential for accelerating the development of new targeted therapies.»
By targeting the fundamental DNA of the gene, the zinc finger therapy also has the advantage over other potential Huntington's therapies of needing less frequent treatments.
Professor Moffatt said: «The genes we identified represent new potential drug targets for allergic diseases as well as biomarkers that may predict which patients will respond to existing expensive therapies.»
Sodium channels are implicated in many serious conditions such as heart disease, epilepsy and pain, making them an important potential target for drug therapies.
So they are a potential target for new therapies for the disease which is incurable according to the present state of research.
In any case, while the results need replication in larger trials, they point to a potential method to target drug therapy for PTSD patients.
The benefits, however, are likely to outweigh the risks because individualized treatments and targeted therapies can be developed with the potential to be applied across the many diseases that are driven or assisted by changes in DNA.
This new knowledge is also making precision medicine a reality by enabling the development of highly targeted therapies that offer the potential for improved treatment outcomes, especially for patients battling cancer.
«This study illustrates the potential of gaining fundamental insights into brain function while helping patients with debilitating diseases, and provides us with a powerful way of selecting targets based on their connectivity to other regions that can be widely applied to help guide brain stimulation therapy across multiple neurological and psychiatric disorders.»
Solt notes that the study strongly suggests that Th17 cells have a pathological role in the development of type 1 diabetes and use of ROR - specific synthetic compounds targeting this cell type may have potential as a preventative therapy for type 1 diabetes.
However, Professor Auguste's team, discovered the overexpression of intercellular adhesion molecule - 1 (ICAM - 1) in human TNBC cell lines and tissues, and demonstrated that it is a potential molecular target and biomarker for TNBC therapy and diagnosis.
Dr George Vassiliou, joint project leader from the Sanger Institute and Consultant Haematologist at Cambridge University Hospitals NHS Trust, said: «This research has led to the identification of many potential gene targets for future AML therapy, which we are making available to other researchers to explore.
«Study reveals potential therapy targets for triple - negative breast cancer.»
Selectively expressed on GBM and absent on surrounding brain tissue, the interleukin - 13 receptor α chain variant 2 (IL13Rα2) was identified as a potential target for therapy for GBM two decades ago.