Sentences with phrase «potential therapeutic targets in»
Research fields are diverse, including basic research on cell proliferation, analysis of tumour cells and tissues to detect gene mutations, and identification of potential therapeutic targets in cancer.
http://www.sciencemag.org/
Further investigation uncovered CHD1's role as vital to PTEN signaling, and as a potential therapeutic target in prostate and breast cancers with PTEN gene loss.
A mini-review of c - Met as a potential therapeutic target in melanoma.
These findings suggest that activation of mTOR signaling contributes to tumor cell survival in ALK + ALCL, thus providing a potential therapeutic target in this lymphoma type.
Nrf2 / ARE Signaling Pathway: Key Mediator in Oxidative Stress and Potential Therapeutic Target in ALS.
Not exact matches
Researchers hope the organoids will be better than lab animals or cells growing in culture at revealing how the human brain develops, both normally and when things go awry, and identify potential therapeutic or genome - editing targets.
«Excitement in the brown fat field has risen significantly over last few years because its energy - burning nature makes it a potential therapeutic target against obesity and diabetes,» said Dr Lee.
«We only used tungsten in «proof - of - concept» experiments to identify a potential molecular target, and we are still far from turning this basic discovery into a therapeutic treatment in patients,» Dr. Winter said.
«PI3K protein: Potential new therapeutic target in pancreatic neuroendocrine tumors.»
«We have identified a pathway in microglia that may be targeted to ultimately slow disease progression in ALS and are exploring potential therapeutic strategies and may have broader implications for diseases such as Alzheimer's and Parkinson's Disease amongst others.»
The publication, «Androgens Regulate Prostate Cancer Cell Growth via an AMPK - PGC - 1α - Mediated Metabolic Switch,» featured online in Oncogene, illuminates a known metabolic pathway as a potential novel therapeutic target.
The work published in Cancer Cell complements previous research efforts from the CNIO Melanoma Group, which could lead to the development of novel drugs that selectively target the mechanism of cell autodigestion as a potential therapeutic strategy.
Based on a report published on August 20, 2015 in Nature Communications, it has been established that certain nutrients support CML stem cell activity in vivo, thus pointing towards a potential therapeutic target for CML therapy.
«Our findings present new potential targets for therapeutic regulation of cross-presentation,» said Filippo Veglia, Ph.D., first author of the study and staff scientist in the Gabrilovich Lab.
«We wanted to identify some potential therapeutic targets that are common not just to one but to multiple forms of retinitis pigmentosa at late - stage disease, when it is more likely to be clinically diagnosed in a patient population.»
Luke Tain: «Given the high evolutionarily conservation of IIS and TOR function, our results implicate potential therapeutic targets to improve sleep quality in humans.
The role of Apelin and Elabela in establishing the circulatory system makes them potential targets in future development of therapeutic applications for illnesses ranging from the various cancers, and cardiovascular diseases, to even metabolic diseases such as diabetes.
Jackson Laboratory research team led by Professor Lenny Shultz, Ph.D., reports that a protein involved in wound healing and tumor growth could be a potential therapeutic target.
According to Dr. Irie, the research is especially important because it supports the potential therapeutic value of targeting PTK6 in ER + breast cancers, which constitute the most common subtype of breast cancer.
The findings, made in mice, explain why most but not all motor neurons are affected by the disease and identify a potential therapeutic target for this still - incurable neurodegenerative disease.
These results not only suggest early mitochondrial biogenesis deficits as a pathogenic mechanism, but also as a potential biomarker and therapeutic target in individuals with Friedreich's ataxia.
«Showing that TWEAK is a critical mediator in both conditions, makes it a potential therapeutic target for the treatment of inflammatory skin diseases in general.»
Now an imaging study finds that psychopathic inmates have deficits in a key empathy circuit in the brain, pointing to a potential therapeutic target.
This suggests that DNA methylation changes that alter excitability may be a mechanism involved in neuropsychiatric disorders, and that the sites of such changes may offer a potential therapeutic target.
This discovery reveals how the repeated expansion in C9ORF72 may cause ALS and demonstrates the therapeutic potential of directly targeting the toxic RNA byproducts generated by the C9ORF72 expansion.
In a new paper published this week in PNAS, researchers describe a potential new class of anti-cancer drugs that inhibit two or more molecular targets at once, maximizing therapeutic efficiency and sa.In a new paper published this week in PNAS, researchers describe a potential new class of anti-cancer drugs that inhibit two or more molecular targets at once, maximizing therapeutic efficiency and sa.in PNAS, researchers describe a potential new class of anti-cancer drugs that inhibit two or more molecular targets at once, maximizing therapeutic efficiency and sa...
An international study led by researchers at Monash University» Biomedicine Discovery Institute (BDI) has shone light on the way the Hepatitis C Virus (HCV) hijacks the communication systems in the host cells it infects, uncovering potential new therapeutic targets for the disease.
Dr. Kirino says that «further studies to understand how SHOT - RNAs promote cell proliferation may lead to the use of SHOT - RNAs as potential target candidates for future therapeutic applications in breast and prostate cancers.»
Potential therapeutic target molecules in these pathways will be highlighted in the conference.
«While the road to heparanase - targeting clinical drugs is long and fraught with risks, with this work we believe to have taken a major step in realising the therapeutic potential of this promising clinical target.»
«Our new structure of the serotonin receptor in the resting state has the potential to serve as a structural blueprint to drive targeted drug design and better therapeutic strategies.»
These findings highlight the potential of Nav1.1 and inhibitory interneurons as a therapeutic target in AD and that disease - specific molecular optimization of cell transplants may be required to ensure therapeutic benefits in different conditions.
The resulting data are being combined in a systems biology approach with high - resolution clinical phenotyping and findings obtained with a large array of established and novel in vitro, ex vivo and in vivo disease models to identify disease - associated genetic variants, disease - defining molecular signatures, and potential targets for therapeutic intervention.
We further expect our results to show that RPE cell - secreted vesicles are essential for cell - to - cell communication connected to spreading RPE degeneration in AMD, and therefore, potential therapeutic targets to halt vision loss in AMD.
I will investigate whether the enteric nervous system, an neglected member of the tumor - microenvironment, plays a role in the development of colorectal cancer and can be used as a potential therapeutic target.
Costimulatory B7 - H1 in renal cell carcinoma patients: Indicator of tumor aggressiveness and potential therapeutic target.
Proteins in the pyroptosis pathway, such as caspase 1, could be potential therapeutic targets to prevent the transition from HIV to AIDS, he added.
In other words, Ras proteins naturally lack areas that are accessible, high - affinity binding targets for potential therapeutic agents.
This project has the potential to uncover clinically relevant mechanisms of cellular senescence in fibrosing ILDs and identify new therapeutic targets
It seems to me that knowing how the drug works, how it acts on a therapeutic target, is an important consideration in prioritizing potential treatments.
In particular, widespread ocular diseases such as age - related macular degeneration (AMD) and retinitis pigmentosa (RP), as well as a genetic condition called Stargardt's macular dystrophy (STGD) that afflicts young people, are all potential disease targets for therapeutic approaches.
By comparing all of the genes that are active in disease and normal tissue, one can get valuable information on new pathways and potential therapeutic targets.
In this protein, the binding domain of botulinum toxin is replaced to broaden the toxin's therapeutic potential and allow drug development to be targeted towards a specific disease.
«The inflammation resolving targeted nanoparticles have shown exciting potential not only for the potential treatment of atherosclerosis as described here, but also other therapeutic areas including wound repair, for example, as described in the Feb. 9 online issue of Journal of Clinical Investigation, in addition to other applications currently underway with our collaborators,» Farokhzad said.
The results of our studies should identify potential mechanisms underlying the white matter abnormalities seen in many degenerative diseases, and may reveal novel therapeutic targets for regenerative medicine.
Approximately 50 % of PTCL are unclassifiable and categorized as PTCL, not otherwise specified (PTCL - NOS).1 Using gene expression profiling, PTCL - NOS lymphocytes can be distinguished from normal T lymphocytes, with deregulation of genes involved in apoptosis, proliferation, cell adhesion, and transcription regulation.2 Two subgroups of PTCL - NOS have been identified, which are characterized by high expression of either GATA3 or TBX21 / T - bet transcription factors and downstream target genes.3 However, actionable biomarkers closely related to the pathogenic mechanism need to be further investigated and may become potential therapeutic targets of PTCL - NOS. 4, 5
NMNATs are potential drug targets for therapeutic interventions in neurodegeneration.
Understanding the role of glial cells in glaucoma as well as what happens to the optic nerve where the retinal nerve axons leave the eye may present new therapeutic targets and even potential biomarkers of glaucoma.
Despite this generally well - accepted idea for how high eye pressure may affect RGC axons, scientists still do not understand the injury mechanisms involved in sufficient detail to begin identifying potential therapeutic targets.
248/3: 30 Necroptosis in Niemann - Pick Disease, type C1: A potential therapeutic target.