Critical issues include: (i) heterogeneity in stem cell populations (ii) regulation of cell fate choices; (iii) declining tissue performance with age and exposure to environmental injuries; (iv) the use of iPS and Embryonic Stem (ES) cells, and reprogramming methods for phenotyping disease states and
potential use of these stem cells in the clinic.
Not exact matches
This includes a
stem cell research centre, a network
of drug discovery institutes and a # 20 million global clinical development fund dedicated to supporting Phase I and II clinical trials; and a # 2 million collaboration between University
of Cambridge and University College London that will
use donated
cells from people with Alzheimer's to test
potential new treatments
Stem cells can transform into any other human
cells, so they have immense
potential for generating all sorts
of adult
cells and thus can be
used in research concerning human degenerative (and other) diseases.
Through CBR ®, we also help families to preserve newborn
stem cells, which are
used today in transplant medicine for certain cancers and blood, immune and metabolic disorders, and have the
potential to play a valuable role in the ongoing development
of regenerative medicine.
Because they can differentiate into almost any
cell type in the body,
stem cells have the
potential to be
used to create healthy
cells to treat a number
of diseases.
«We've shown that SIF - seq can be
used to identify enhancers active in cardiomyocytes, neural progenitor
cells, and embryonic
stem cells, and we think that it has the
potential to be expanded for
use in a much wider variety
of cell types,» Dickel says.
Research involving the derivation and
use of embryonic
stem (ES)
cells is permissible only where there is strong scientific merit in, and
potential medical benefit from, such research.
«Our findings determine the
potential negative effects
of inflammation on
stem cell function as they're currently
used.
Researchers, led by Joshua Mayourian at the Icahn School
of Medicine at Mount Sinai,
used mathematical modeling to simulate electrical interactions between these
stem cells and heart
cells to develop insight into possible adverse effects, as well as to hypothesize new methods for reducing some
potential risks
of this therapy.
«The next step
of progress is to
use this knowledge to decipher what
potential impact the genetic variants can have on the health
of individuals, when we conduct health - related research,» added Professor Michael Pepper, Unit Director
of the South African Medical Research Council's (SAMRC)
Stem Cell Research and Therapy Unit, Faculty
of Health Sciences at the University
of Pretoria.
Using a mouse model, the team also demonstrated that two processes during neurodevelopment are regulated by the gene: proliferation — the replication
of neuronal
stem cells that have the
potential to become multiple different kinds
of cells, including neurons — and migration — the movement
of neurons to specific locations in the brain during development.
The authors conclude that mesenchymal
stem cell therapy has great
potential as a therapeutic option in feline disease, but that many questions about the logistics
of its
use remain to be answered.
A new study in mice published in The Journal
of Neuroscience details a
potential therapeutic strategy that
uses stem cells to promote recovery
of motor activity after spinal cord injury.
Potential scientific questions from this research relate to the origin and function
of stem cell clones and to whether they could be
used to predict future outcomes.
The achievement represents a new direction in the
use of human pluripotent
stem cells, which have the
potential to develop into any
of the tissues
of the human body.
Researchers say the finding places important restrictions on the
potential therapeutic
use of neural
stem cells.
That still makes them a
potential source
of ES
cells, and because human parthenote embryos can't develop to term, some people have fewer qualms about
using them to produce
stem cells.
To understand the functional role
of miR - 7 in CSCs, we first searched its
potential target genes that may be involved in
stem cell physiology
using multiple database including TargetScan, PicTar, miRanda, and SLOAN - Kettering.
Other
potential uses of embryonic
stem cells include investigation
of early human development, study
of genetic disease and as in vitro systems for toxicology testing.
«It suggests to us that targeting the pathways
used in regulating
cell fate decisions — how
stem cells choose between
cell proliferation and differentiation — could be a more effective way
of halting tumours in their tracks and lead to
potential new therapies.»
The
potential of iPS
cells to help treat everything from damaged heart tissue to Parkinson's disease, has prompted intensive research that has looked into the
use of skin fibroblast
cells as an alternative to controversial embryonic
stem cells.
In this study, induced pluripotent
stem (iPS)
cells, which have the
potential to differentiate into any type
of cell in the body, were
used to model the disease.
After hearing a brief explanation that laid out the different sources
of stem cells (but left undiscussed their current
uses or future
potential for therapy), the respondents offered a slightly more nuanced set
of views, and only a slight majority (52 %) supported embryonic
stem cell research.
The exploration
of the therapeutic
potential of stem cells requires the characterization
of their biological properties, the deciphering
of the mechanisms that underlie their pluripotency and their capacity at differentiation, by the understanding
of the signals that direct their fate towards discrete
cell phenotypes... Their therapeutic
use requests further, in particular in the case
of substitutive therapies, the analysis
of their capacities
of integration in injured adult tissues and
of their
potential tumorigenicity, as well as the development
of original ways
of delivery.
A full realisation
of the medical
potential of stem cells for human health will likely depend on a reinforcement
of, and development
of a whole continuum
of studies ranging from those in vivo
using model organisms, to
cell - based therapies in the clinic.
Our Areas
of Interest IFATS current scientific areas
of interest relate to facilitating the development
of treatments for excess body fat, the generation
of new fat tissue for reconstruction after cancer or birth - related defects and the
use of adipose tissue as a source
of mesenchymal
stem cells that have the
potential to regenerate and repair different body tissues.
While 2016 saw many articles on unproven
stem cell therapies, and the controversial
use of MRT, there were many positive stories about
potential stem cell - derived therapies that are successfully moving into the clinic for testing.
Treating HIV: Although hematopoietic
stem cells have been
used since World War II to treat victims
of radiation, a
potential, significant new application was reported just last year: Hematopoietic
stem cells were
used to successfully treat a patient with HIV, although the procedure is currently risky and much additional research is necessary for it to be widely accepted and
used.
The guidelines were originally produced to offer a common set
of ethical standards for the responsible conduct
of research
using human embryonic
stem cells, which have the
potential to produce all the body's
cell types.
These findings will enable increasing numbers
of researchers across the world to
use these
stem -
cell like
cells to study disease and explore
potential regenerative therapies.
In any event, the
use of induced pluripotent
stem cells has the
potential to get around many
of these ethical concerns.»
Massachusetts Institute
of Technology (MIT) researchers have discovered a new way to model malaria
using stem cells in a petri dish, which will allow them to test
potential antimalarial drugs and vaccines.
Other programs will
use cellular models
of heart disease created from
stem cells to identify
potential new drug targets.
His team is
using innovative
cell culture models to advance our understanding
of brain
stem cells and their
potential role in glioblastoma.
The properties
of stem cells can be applied in disease mechanism investigations, helping with the identification
of potential drug targets or for
use in
cell transplantation.
As soon as I learned about the incredible
potential of regenerative medicine, I was drawn to the idea
of using stem cells to replace or augment biological systems.
Virtually identical to human embryonic
stem cells (hESCs) except for their origin
of isolation, the recently created induced pluripotent
stem cells (iPSCs)(Yu et al., 2007; Takahashi et al., 2007) hold much
potential for
use in regenerative therapies.
In this role, Ms. Roxland re-launched and chaired J&J's Ethics Committee, created an enterprise - wide consultation service for teams and individuals confronting complex research ethics issues, and provided guidance on issues such as post-trial access for former research participants, conducting clinical trials in war - torn regions, testing
of a
potential Ebola vaccine during a public health crisis, commercialization
of stem cell therapies, subject recruitment and withdrawal, and expanded access / compassionate
use.
SOX2 is one
of two key genes researchers
use to generate induced pluripotent
stem cells (iPSCs), which are capable
of differentiating into all
cell types for research and
potential therapeutic applications.
Researchers
using a novel technique find that
potential therapeutic worth
of mesenchymal
stem cells is linked to their motility
Studies
using a mouse model
of type 1 diabetes highlight a
potential role for human adipose
stem cells in treatment regimens and, further, they reveal a secreted factor which has important therapeutic relevance
While
stem cell research has enormous
potential to yield new therapies for other diseases, in most cases, years
of research will be required to identify the diseases that can benefit from
stem cell treatments and to figure out how
stem cells can be
used safely and effectively in those contexts.
Her lab is examining the
potential of using biomaterials for
stem cell differentiation and engineering mesenchymal tissues.
The advent
of human induced pluripotent
stem cells has been heralded as a major breakthrough in the study
of pluripotent
stem cells, for these
cells have yielded fundamental insights into the reprogrammability
of somatic
cell fates, but also because
of their seemingly great promise in applications, including
potential uses in
cell therapy.
It also opens up
potential avenues in embryology that would have been inconceivable otherwise — for example,
using stem cells to accurately study the embryology
of whales and other species with much longer (or shorter) gestation rates than humans.
Using cloning technology to derive embryonic
stem cells genetically identical to a patient is potentially very important, not only to provide a source
of cells that may be
used to cure patients, but also to allow for genetic disease to be studied and
potential drug treatments to be explored in the laboratory.
More recently, recombinant TAT - HOXB4 was
used to expand hematopoietic
stem cells up to 20-fold without the need for viral gene transfection, avoiding the
potential hazards
of inducing lymphoproliferative disease [15].
His team has made a bank
of stem cells that are ready to be
used in humans, with the
potential to treat some six million patients.
This poster describes the isolation and maintenance in culture
of pluripotent
stem cells, their differentiation, and the generation and
potential uses of organoids.
However welcome the recent announcement that a team
of scientists based at Newcastle University, has grown a section
of human liver
using stem cells from umbilical cords, rather than from the more controversial source
of embryonic
stem cells, and whatever the eventual promise or
potential of harvesting organs for transplantation from genetically modified pigs, the benefits
of either
of these two pioneering techniques to currently dying / suffering patients, remain both elusive and distant.