Sentences with phrase «potential use of these stem cells»

Critical issues include: (i) heterogeneity in stem cell populations (ii) regulation of cell fate choices; (iii) declining tissue performance with age and exposure to environmental injuries; (iv) the use of iPS and Embryonic Stem (ES) cells, and reprogramming methods for phenotyping disease states and potential use of these stem cells in the clinic.

Not exact matches

This includes a stem cell research centre, a network of drug discovery institutes and a # 20 million global clinical development fund dedicated to supporting Phase I and II clinical trials; and a # 2 million collaboration between University of Cambridge and University College London that will use donated cells from people with Alzheimer's to test potential new treatments

Stem cells can transform into any other human cells, so they have immense potential for generating all sorts of adult cells and thus can be used in research concerning human degenerative (and other) diseases.

Through CBR ®, we also help families to preserve newborn stem cells, which are used today in transplant medicine for certain cancers and blood, immune and metabolic disorders, and have the potential to play a valuable role in the ongoing development of regenerative medicine.

Because they can differentiate into almost any cell type in the body, stem cells have the potential to be used to create healthy cells to treat a number of diseases.

«We've shown that SIF - seq can be used to identify enhancers active in cardiomyocytes, neural progenitor cells, and embryonic stem cells, and we think that it has the potential to be expanded for use in a much wider variety of cell types,» Dickel says.

Research involving the derivation and use of embryonic stem (ES) cells is permissible only where there is strong scientific merit in, and potential medical benefit from, such research.

«Our findings determine the potential negative effects of inflammation on stem cell function as they're currently used.

Researchers, led by Joshua Mayourian at the Icahn School of Medicine at Mount Sinai, used mathematical modeling to simulate electrical interactions between these stem cells and heart cells to develop insight into possible adverse effects, as well as to hypothesize new methods for reducing some potential risks of this therapy.

«The next step of progress is to use this knowledge to decipher what potential impact the genetic variants can have on the health of individuals, when we conduct health - related research,» added Professor Michael Pepper, Unit Director of the South African Medical Research Council's (SAMRC) Stem Cell Research and Therapy Unit, Faculty of Health Sciences at the University of Pretoria.

Using a mouse model, the team also demonstrated that two processes during neurodevelopment are regulated by the gene: proliferation — the replication of neuronal stem cells that have the potential to become multiple different kinds of cells, including neurons — and migration — the movement of neurons to specific locations in the brain during development.

The authors conclude that mesenchymal stem cell therapy has great potential as a therapeutic option in feline disease, but that many questions about the logistics of its use remain to be answered.

A new study in mice published in The Journal of Neuroscience details a potential therapeutic strategy that uses stem cells to promote recovery of motor activity after spinal cord injury.

Potential scientific questions from this research relate to the origin and function of stem cell clones and to whether they could be used to predict future outcomes.

The achievement represents a new direction in the use of human pluripotent stem cells, which have the potential to develop into any of the tissues of the human body.

Researchers say the finding places important restrictions on the potential therapeutic use of neural stem cells.

That still makes them a potential source of ES cells, and because human parthenote embryos can't develop to term, some people have fewer qualms about using them to produce stem cells.

To understand the functional role of miR - 7 in CSCs, we first searched its potential target genes that may be involved in stem cell physiology using multiple database including TargetScan, PicTar, miRanda, and SLOAN - Kettering.

Other potential uses of embryonic stem cells include investigation of early human development, study of genetic disease and as in vitro systems for toxicology testing.

«It suggests to us that targeting the pathways used in regulating cell fate decisions — how stem cells choose between cell proliferation and differentiation — could be a more effective way of halting tumours in their tracks and lead to potential new therapies.»

The potential of iPS cells to help treat everything from damaged heart tissue to Parkinson's disease, has prompted intensive research that has looked into the use of skin fibroblast cells as an alternative to controversial embryonic stem cells.

In this study, induced pluripotent stem (iPS) cells, which have the potential to differentiate into any type of cell in the body, were used to model the disease.

After hearing a brief explanation that laid out the different sources of stem cells (but left undiscussed their current uses or future potential for therapy), the respondents offered a slightly more nuanced set of views, and only a slight majority (52 %) supported embryonic stem cell research.

The exploration of the therapeutic potential of stem cells requires the characterization of their biological properties, the deciphering of the mechanisms that underlie their pluripotency and their capacity at differentiation, by the understanding of the signals that direct their fate towards discrete cell phenotypes... Their therapeutic use requests further, in particular in the case of substitutive therapies, the analysis of their capacities of integration in injured adult tissues and of their potential tumorigenicity, as well as the development of original ways of delivery.

A full realisation of the medical potential of stem cells for human health will likely depend on a reinforcement of, and development of a whole continuum of studies ranging from those in vivo using model organisms, to cell - based therapies in the clinic.

Our Areas of Interest IFATS current scientific areas of interest relate to facilitating the development of treatments for excess body fat, the generation of new fat tissue for reconstruction after cancer or birth - related defects and the use of adipose tissue as a source of mesenchymal stem cells that have the potential to regenerate and repair different body tissues.

While 2016 saw many articles on unproven stem cell therapies, and the controversial use of MRT, there were many positive stories about potential stem cell - derived therapies that are successfully moving into the clinic for testing.

Treating HIV: Although hematopoietic stem cells have been used since World War II to treat victims of radiation, a potential, significant new application was reported just last year: Hematopoietic stem cells were used to successfully treat a patient with HIV, although the procedure is currently risky and much additional research is necessary for it to be widely accepted and used.

The guidelines were originally produced to offer a common set of ethical standards for the responsible conduct of research using human embryonic stem cells, which have the potential to produce all the body's cell types.

These findings will enable increasing numbers of researchers across the world to use these stem - cell like cells to study disease and explore potential regenerative therapies.

In any event, the use of induced pluripotent stem cells has the potential to get around many of these ethical concerns.»

Massachusetts Institute of Technology (MIT) researchers have discovered a new way to model malaria using stem cells in a petri dish, which will allow them to test potential antimalarial drugs and vaccines.

Other programs will use cellular models of heart disease created from stem cells to identify potential new drug targets.

His team is using innovative cell culture models to advance our understanding of brain stem cells and their potential role in glioblastoma.

The properties of stem cells can be applied in disease mechanism investigations, helping with the identification of potential drug targets or for use in cell transplantation.

As soon as I learned about the incredible potential of regenerative medicine, I was drawn to the idea of using stem cells to replace or augment biological systems.

Virtually identical to human embryonic stem cells (hESCs) except for their origin of isolation, the recently created induced pluripotent stem cells (iPSCs)(Yu et al., 2007; Takahashi et al., 2007) hold much potential for use in regenerative therapies.

In this role, Ms. Roxland re-launched and chaired J&J's Ethics Committee, created an enterprise - wide consultation service for teams and individuals confronting complex research ethics issues, and provided guidance on issues such as post-trial access for former research participants, conducting clinical trials in war - torn regions, testing of a potential Ebola vaccine during a public health crisis, commercialization of stem cell therapies, subject recruitment and withdrawal, and expanded access / compassionate use.

SOX2 is one of two key genes researchers use to generate induced pluripotent stem cells (iPSCs), which are capable of differentiating into all cell types for research and potential therapeutic applications.

Researchers using a novel technique find that potential therapeutic worth of mesenchymal stem cells is linked to their motility

Studies using a mouse model of type 1 diabetes highlight a potential role for human adipose stem cells in treatment regimens and, further, they reveal a secreted factor which has important therapeutic relevance

While stem cell research has enormous potential to yield new therapies for other diseases, in most cases, years of research will be required to identify the diseases that can benefit from stem cell treatments and to figure out how stem cells can be used safely and effectively in those contexts.

Her lab is examining the potential of using biomaterials for stem cell differentiation and engineering mesenchymal tissues.

The advent of human induced pluripotent stem cells has been heralded as a major breakthrough in the study of pluripotent stem cells, for these cells have yielded fundamental insights into the reprogrammability of somatic cell fates, but also because of their seemingly great promise in applications, including potential uses in cell therapy.

It also opens up potential avenues in embryology that would have been inconceivable otherwise — for example, using stem cells to accurately study the embryology of whales and other species with much longer (or shorter) gestation rates than humans.

Using cloning technology to derive embryonic stem cells genetically identical to a patient is potentially very important, not only to provide a source of cells that may be used to cure patients, but also to allow for genetic disease to be studied and potential drug treatments to be explored in the laboratory.

More recently, recombinant TAT - HOXB4 was used to expand hematopoietic stem cells up to 20-fold without the need for viral gene transfection, avoiding the potential hazards of inducing lymphoproliferative disease [15].

His team has made a bank of stem cells that are ready to be used in humans, with the potential to treat some six million patients.

This poster describes the isolation and maintenance in culture of pluripotent stem cells, their differentiation, and the generation and potential uses of organoids.

However welcome the recent announcement that a team of scientists based at Newcastle University, has grown a section of human liver using stem cells from umbilical cords, rather than from the more controversial source of embryonic stem cells, and whatever the eventual promise or potential of harvesting organs for transplantation from genetically modified pigs, the benefits of either of these two pioneering techniques to currently dying / suffering patients, remain both elusive and distant.