To order a Toller Progressive Red Cone Degeneration (PRCD) blood test: Detailed instructions are available from OptiGen's website that explain how to ship a sample, request a test and information about the Toller
PRCD test.
The OptiGen
prcd test for American Eskimo Dogs provides almost 100 % identification of these dogs.
The OptiGen
prcd test for Entlebucher Mountain Dogs provides almost 100 % identification of these dogs.
Failure to do annual eye exams through at least 10 years of age, or assuming that any retinal defect found can't be inherited because the dog or its parents have cleared
the prcd test has the potential to result in increased frequency of those other and presently rare forms of retinal disease because breeders are makng mating choices based on false assumptions.
Because there is more than one form of PRA, if there should happen to be a second form in the breed and your dog had the genes for that type it would be possible to test your dog «for PRA» using
the PRCD test with clear results when the dog is actually affected — but with a different form of PRA.
Any Aussie that is thought to be affected with PRA should have
the PRCD test to confirm the diagnosis.
Not exact matches
ALL OF MY BREEDING DOGS ARE
TESTED FOR
PRCD - PRA (Progressive Retinal Atrophy) which causes blindness in poodles thru OPTIGEN in Ithaca, New York.
They will screen the dog not only for
prcd but the other types of PRA for which there are DNA
tests as well.
Based on the settlement, Paw Print Genetics now holds the exclusive North American sublicense from OptiGen for PRA -
prcd, CEA, CSNB and RD / OSD
testing in the U.S. and Canada.
The patents at issue in the case are owned by Cornell University and are licensed to OptiGen for canine genetic
testing related to progressive retinal atrophy (PRA -
prcd), Collie eye anomaly (CEA), congenital stationary night blindness (CSNB), and Retinal dysplasia / Oculoskeletal dysplasia (RD / OSD).
If
PRCD is suspected there is a DNA
test that can confirm the diagnosis.
Tested to determine the progressive rod - cone (
prcd) / PRA and CEA (collie eye anomaly) DNA status «Clear, Carrier or Affected» if unknown by parentage.
Optigen today announced that the linkage
test for the
prcd form of PRA will soon be available in two additional breeds, English Cocker Spaniels, and Chesapeake Bay Retrievers.
In there work, they ahve determined that IGs do not have the
prcd form of PRA, so the
test mentioned below is not valid in IGs.
The Labrador Retriever Club support the use of OFA Data Bases, Penn Hip, CERF and other individual
tests such as the
test for CNM1, the Optigen
tests for the
prcd form of PRA in the Labrador Retriever, and the new
test for EIC.
June 1, 2005 New Mutation
Test for
prcd PRA Is Now Available OptiGen, LLC, proudly announces identification of the gene causing canine
prcd - PRA (progressive rod - cone degeneration form of Progressive Retinal Atrophy).
The
test analyzes the specific DNA mutation causing
prcd - PRA.
OptiGen now offers a direct gene mutation
test (mutation
test) to detect the
prcd - PRA status of any dog among affected breeds.
February 14, 2008 DKK Health Registry Announcement January 17, 2008 News Update on
prcd - PRA
Testing in Europe January 8, 2008 Traduction en français des formulaires de demande de
tests December 7, 2007 Normal to Normal Offspring
Tested at Reduced Prices
The OptiGen
prcd - PRA
test is a DNA - based
test that helps you avoid one form of Progressive Retinal Atrophy (PRA).
The
prcd - PRA
test is done on a small sample of blood obtained by your veterinarian.
It's been proven that all breeds being
tested for
prcd - PRA have the same disease caused by the same mutated gene.
The only one of these
tests that should be used for Aussies is the one for Progressive Rod Cone Degeneration (
PRCD).
For any Spanish Water Dog and Australian Shepherds that does not have a diagnosis of PRA, OptiGen will accept samples for
prcd - PRA
testing at the fee schedule viewable on the website.
The number of Spanish Water Dog and Australian Shepherds samples that have been
tested for
prcd is low and at this point it is not possible to determine the prevalence of the disease within the breed.
Nov. 27, 2006 — News Release — GENETIC
TEST FOR
prcd - PRA ANNOUNCED FOR Spanish Water Dog and Australian Shepherds — Ithaca, New York, USA.
The OptiGen
test for PRA in the Spanish Water Dog and Australian Shepherds identifies a mutation in the
prcd gene that was discovered through extensive research in the laboratories of Dr. Gustavo Aguirre and Dr. Gregory Acland at Cornell University (Zangerl et al., Genomics 88, 551 - 563, 2006).
As an individual breeder, if you are considering importing a dog you should only do so if it has had its hips and elbows cleared, has had a clear eye exam within the past year, a thyroid panel, Pelger - Huet Anomaly screen, and has been DNA
tested for MDR1, cataracts, CEA, the
PRCD form of PRA, degenerative myelopathy, and cobalamin malabsorbtion.
With the other genetic
tests currently available for Australian Shepherds, most notably MDR1, CEA and PRA, the answer to the «what to do» question is straightforward: Having a single copy of the CEA - CH or
prcd / PRA mutations or even two of the MDR1 are not reasons to remove a dog from your breeding program.
PRA of any type is rare in Aussies, but most of those who do have it have the progressive rod - cone degeneration (
prcd) form, which is what people typically
test for.
Any Aussie diagnosed with PRA should also have the
PRCD DNA
test to confirm the diagnosis.
If a dog with a PRA diagnosis does not have
prcd, Optigen will also screen the sample to see if it might have one of the other forms for which they have a
test.
DNA
tests are available for several diseases that affect Golden Retrievers (such as for
prcd - PRA, GR - PRA1, and ichthyosis), and more will certainly be added over time.
Given the multiple forms of PRA, if an Aussie is diagnosed with the disease it would be wise to confirm the diagnosis by having it
tested for
prcd (which Optigen, the lab offering the
test, will do for no charge.)
If the disease is uncommon, as with the progressive rod - cone degeneration (
PRCD) form of Progressive Retinal Atrophy in Australian Shepherds, or if use of a
test and careful breeding decisions have markedly reduced the frequency of a formerly common mutation (think what could be done with CEA in Collies,)
testing could then be confined to only those dogs with known family history of the disease or with relatives that have been DNA
tested as carriers.
For example, the
prcd - PRA DNA
test detects one specific mutation in the
prcd gene and the XL - PRA
test detects a specific mutation in a different gene.
The PRA
test for the Labrador (
prcd - PRA) is different than the PRA
test for the Samoyed (XL - PRA).
Multiple
Tests for Labrador retrievers or Samoyeds not tested previously by OptiGen: There is a discounted price for ordering multiple tests on one sample (e.g. prcd - PRA and RD / OSD, or XL - PRA and RD /
Tests for Labrador retrievers or Samoyeds not
tested previously by OptiGen: There is a discounted price for ordering multiple
tests on one sample (e.g. prcd - PRA and RD / OSD, or XL - PRA and RD /
tests on one sample (e.g.
prcd - PRA and RD / OSD, or XL - PRA and RD / OSD).
To date, OptiGen has
tested hundreds of golden retrievers from multiple lines and countries for
prcd - PRA and so we can now provide more extensive information on the incidence of the disease in this breed.
OptiGen holds an exclusive international license from Cornell University for the
testing of
prcd - PRA.
This in turn leads to the
testing of Goldens with a higher chance of carrying the
prcd mutation than would be expected in the general population.
This situation is very different than for the initial
prcd - PRA
test in other breeds where the rate of false positives was substantial.
Two dogs out of 250 research dogs did not show as «affected» using the
prcd - PRA mutation
test for ACDs, even though they appeared to have PRA upon exam by Dr. Acland.
These conditions are not detectable with OptiGen's
test for
prcd - PRA.
Since the
test for
prcd - PRA can only reveal the existence of affected or carrier status of this one form of PRA, breeders and owners of the breed should still have regular eye exams by veterinary ophthalmologists.
The OptiGen
prcd - PRA genetic
test was validated for these breeds using DNA samples from the US and from Europe.
The
prcd - PRA
test is performed on a sample of unclotted blood.
Genetic
testing of the
PRCD gene will reliably determine whether a dog is a genetic Carrier of PRA - p
PRCD gene will reliably determine whether a dog is a genetic Carrier of PRA -
prcdprcd.
Genetic
testing may help clarify if a dog is affected with PRA -
prcd or another inherited condition of the eye.
The
test eliminates the guess work from a breeding program with respect to
PRCD — the only form of PRA seen in Tollers which results in blindness.