Sentences with phrase «pre-clinical model of the disease»

Researchers at Penn State College of Medicine, working with Chinese and American colleagues, have discovered a novel way to enhance and restore cancer suppressor activity in B - cell acute lymphoblastic leukemia, resulting in better outcomes in a pre-clinical model of the disease.

Not exact matches

Durante said the next step will be a pre-clinical trial to test glutamine's effect on a mouse model of coronary artery disease.

The researchers chose to test their delivery method with GDNF because the therapy has been shown to delay and even reverse disease progression of Parkinson's disease in pre-clinical models.

The objective of Kogenix is to achieve the initial capital needed to advance in the pre-clinical trials already being conducted with animal models of Alzheimer's disease.

Many diseases can be detected at the surface of tissues, including cancer, while many pre-clinical studies are performed with animal models and engineered three - dimensional tissues that can benefit from being monitored non-destructively.

the generation of novel mouse models of Cystic Fibrosis by exploring genetically - diverse murine populations that will provide unique tools for disease modeling and pre-clinical studies.

Likewise, reproducible, reliable and cost - effective determinations of disease biomarkers detectable in body fluids are a requirement in pre-clinical research carried out in mouse models.

This call for projects «Mouse models and rare diseases» aims to give a significant boost to the development of mouse models, in order to: ◊ gain a better understanding of the pathophysiological mechanisms involved in rare diseases whose defective genes have been identified ◊ test and validate therapeutic proofs of concept, at the pre-clinical in vivo level Indeed, producing these models meets a key objective in the development of a therapeutic strategy.

Her group has developed pre-clinical models of metastatic disease that are used to identify genes, both in the tumour cells and in the tumour micro-environment that regulate the process of metastasis to specific organs such as bone, liver, lung and brain.

Examples of studies conducted with assistance of the Center are pre-clinical studies of orthopedic devices intended for animal and human use, clinical studies of treatment and prevention of respiratory diseases in horses and animal clinical trials evaluating the treatment of bladder cancer in Scottish Terriers, an animal model of human bladder cancer.