Sentences with phrase «pre-coupled macromolecular»

Now Monod shows that the machinery by which the cell (Or at least the non-primitive cell, which is the only one we know) translates the codes «consists of at least fifty macromolecular components which are themselves coded in DNA.»

Not only did he lift three trophies with Roma's Primavera squad, but he's also a member of the Department of Biochemistry at the University of Cambridge specializing in macromolecular mechanisms of genome duplication and stability.

Ameer's lab is now developing an improved second - generation biomaterial with greater strength, degradation control, and macromolecular regulation.

This meant leaving protein synthesis aside for a while, instead working on viruses and macromolecular immune complexes.

At the same time, he was appointed part - time scientist at the nearby Research Centre for Macromolecular Materials and Membranes of Bucharest (RCMMM).

A macromolecular fraction from mouse salivary glands markedly enhances growth of mesenchymal tissues in vitro.

Therefore, before publication, large data sets (including microarray data, protein or DNA sequences, atomic coordinates or electron microscopy maps for molecular and macromolecular structures, and climate data) must be deposited in an approved database and an accession number or a specific access address must be included in the published paper.

«Two - step processes our lab and others developed earlier lack a seamless interface and, therefore, lack the conductance sought,» said Liming Dai, the Kent Hale Smith Professor of Macromolecular Science and Engineering at Case Western Reserve University and a leader of the research.

Shieh is currently leading the International Institute of Macromolecular Analysis and Nanomedicine Innovation (IMANI), which is focused on translating molecular discoveries to the clinic.

«The specific macromolecular complex investigated in this study has therapeutic implications not only for addiction, but also for Parkinson's disease and schizophrenia,» said Dr. Sergi Ferré, who led the team of scientists.

«Study changes long - held concepts of cell decoding: Scientists discover macromolecular complexes that could enable medication development.»

Unlike the particles in a coffee drop, the liquid crystal drop they studied was a solution of Sunset Yellow molecules that spontaneously combine to form rod - like macromolecular assemblies, similar to how rod - like molecules order to form the liquid crystals used in LCDs.

The NIDA scientists conclude that GPCRs form part of very elaborate pre-coupled macromolecular complexes.

The pair are corresponding authors on a paper appearing online on Feb 2 in the journal Small titled «Precise Manipulation and Patterning of Protein Crystals for Macromolecular Crystallography Using Surface Acoustic Waves.»

Neela Yennawar, director of the Huck Institute's Macromolecular X-ray Facility at Penn State and a co-author on the paper in Small, said «Crystallographers are pushing the boundary of biological samples being studied and moving towards more difficult targets of higher molecular weight and complexity.

Epps, who is the Thomas and Kipp Gutshall Professor of Chemical and Biomolecular Engineering and professor of Materials Science and Engineering at UD, and two of his graduate students, Melody Morris and Thomas Gartner, recently published an article highlighting this work in Macromolecular Chemistry and Physics.

His research focuses on the development of high - precision, single - molecule methods to study the mechanism of action of macromolecular machines, such as dynein, telomerase, and Cas9.

«Silicon nanosheets are particularly interesting because today's information technology builds on silicon and, unlike with graphene, the basic material does not need to be exchanged,» explains Tobias Helbich from the WACKER Chair for Macromolecular Chemistry at TUM.

Now Helbich, in collaboration with Professor Bernhard Rieger, Chair of Macromolecular Chemistry, has for the first time successfully embedded the silicon nanosheets into a polymer, protecting them from decay.

Instead, the researchers, led by Wang and macromolecular science professor Huisheng Peng, swapped out those toxic and flammable liquids for cheap and environmentally conscious sodium - ion solutions.

Robinson - Mosher could've worked for Pixar, Silver says, but he now uses his simulation skills to understand macromolecular interactions, research that could help scientists engineer novel proteins for drugs.

Enzymes are macromolecular biological catalysists that lead most of chemical reactions in living organisms.

As researchers gradually gain more insight into the genome's hierarchy of structures, they will get closer to figuring out how this macromolecular wonder works in all of its vastness and mechanistic detail.

The work is based in the Rosetta macromolecular modeling package developed by Baker and his colleagues.

A team of researchers led by the Department of Energy's Oak Ridge National Laboratory used neutron macromolecular crystallography to investigate the different states of three glaucoma drugs as they interact with the targeted enzyme, human carbonic anhydrase II (hCA II).

«If this is to be any serious use, I suspect it will be in collaboration with existing super-resolution techniques, on small macromolecular complexes, to push the boundaries a bit further, rather than looking at whole cells.»

Glotzer is also a professor of material science and engineering, macromolecular science and engineering, and physics.

«However, I am supportive of any attempt to reverify the role of macromolecular synthesis observed immediately after the encoding of memory.»

Molecular dynamics was used to refine macromolecular structures by incorporating the difference between the observed crystallographic structure factor amplitude and that calculated from an assumed atomic model into the total energy of the system.

As the macromolecular version of mechanically interlocked molecules, mechanically interlocked polymers are promising candidates for the creation of sophisticated molecular machines and smart soft materials.

This process takes place inside veritable macromolecular machines known as ribosomes, and starts by transcribing genetic information from a cell's DNA into transportable units known as messenger RNAs (mRNAs).

The course is offered by Brookhaven Labs Biology and National Synchrotron Light Source departments, and reflects an educational component of the PXRR (Macromolecular Crystallography Research Resource), funded jointly by the National Center for Research Resources a branch of the National Institutes of Health (NIH) and the U.S. Department of Energys Office for Biological & Environmental Research.

Because of the complex structure of spider silk, large scale synthetic production still remains a challenge and can only be achieved through a controlled self - assembly of the macromolecular components with nanoscale precision [2].

The weeklong crash course is designed to introduce participants to the best and latest equipment and techniques for macromolecular x-ray crystallography.

«The significance of this study is that we're going to see more comparative studies of macromolecular concentrations — such as differences in proteins and lipids — which reveal things that can't be read out directly» from the genome, says Todd Preuss, a neuroscientist at Emory University who specializes in the evolution of the human brain and who was not involved in the study.

Single - particle cryoelectron microscopy (cryoEM) is now able to provide structures of macromolecular assemblies to resolutions approaching 3 Å, sufficient to allow the polypeptide chain fold to be traced in a number of cases.

(Collaborative Computational Project, Number 4) a collection of programs and associated data and software libraries used for macromolecular structure determination by X-ray crystallography.

The main experimental technologies that Instruct offers are complementary, and increasingly link detailed atomic structure of single molecules or macromolecular complexes with their cellular context.

One needs no oracle to predict that this will eventually be the fate of many, if not most, macromolecular crystallographers.

CCP4 got its start in the 1970s when a number of new macromolecular crystallography groups spawned from the pioneering labs at the Laboratory of Molecular Biology at Cambridge and the biophysics department at Oxford.

As a Giovanni Armenise - Harvard Professor of Basic Medical Sciences at Harvard Medical School and Children's Hospital Boston and Howard Hughes Medical Institute Professor, Dr. Harrison studies protein interactions of viruses and antibodies to understand the organization and dynamics of these macromolecular assemblies.

Topic: Automated macromolecular structure solution from SAD and MR - SAD experiments with Crank2 Presenter: Navraj Pannu, Assistant Professor Leiden University, The Netherlands Host: Jason Key Recorded on March 8, 2016

A partial list would include the Patterson function, isomorphous replacement, and anomalous scattering, which enabled the determination of organic structures; direct (i.e., purely computational) methods of phase determination, which enabled small - molecule crystallography to be almost totally automated; synchrotron radiation and area detectors, which together made it possible to collect data on macromolecular structures in hours instead of months; and automatic interpretation of electron density maps.

The structural analysis guides further mutagenesis and biochemical experiments in both reconstituted systems in vitro and in primary cells, to finely analyze the mechanisms that mediate macromolecular function, or lead to a pathological dysfunction.

an image processing framework to obtain 3D models of macromolecular complexes using 3D EM that allows you to execute workflows combining different software tools, while taking care of formats and conversions.

Access to third generation synchrotron beamlines for macromolecular crystallography In collaboration with the ESRF, we provide access to seven macromolecular crystallography beamlines at the ESRF and an EU funded User Programme exists to support this access.

He served as a steering committee member of the EPSRC Innovative Manufacturing Research Center for Bioprocessing and Center for Innovative Manufacturing in Emergent Macromolecular Therapies, both at University College London.

His research focuses on the development of algorithms for determination of macromolecular structures and determining structures of proteins from pathogenic organisms He is a member of the Phenix software development team.

The power and glory of X-ray crystallography were that it was the first technique to show our eyes what the atomic world really looked like — initially for minerals and simple solids; then for small organic substances; eventually for giant molecules, macromolecular assemblies, and even organelles like the ribosome.

Optical imaging and spectroscopy, advanced optical imaging techniques in particular super-resolution fluorescence microscopy, optical physics, nanotechnology, single - molecule biophysics and macromolecular biochemistry, single - molecule imaging, gene expression, computational modeling, single - molecule (force) spectroscopy, biomolecular engineering, nucleic acid nanotechnology