Taken together, these observation impinge on one central problem: the development of rational targeting strategies aimed at overcoming therapeutic resistance require
the precise elucidation of the molecular mechanisms whereby carcinoma cells that undergo EMT acquire the functional traits that render them resistant to conventional therapy.
Not exact matches
«Two other evolutionary transitions vital to our understanding of the relationship between whales and artiodactyls beg for
elucidation: the
precise ancestry of hippopotami and the origin of artiodactyls themselves,» Kenneth D. Rose of Johns Hopkins University comments in a perspective article accompanying the Science report.
Genome editing technology enables
precise modification of individual protein coding genes, as well as noncoding regulatory sequences, enabling the
elucidation of functional effects in human disease relevant cellular systems.