Sentences with word «preclinical»

The researchers intend to make use of their new method in preclinical studies in the future and continue to develop it — for example, applying it to infections and to rheumatological and arthritic diseases.

The close collaboration with the Assisted Reproduction Unit, performing about 1,500 ovarian stimulation cycles / year, offers the possibility to validate the results of preclinical studies in a large cohort of patients.

In a study of preclinical models of colorectal cancer, the researchers identified an underlying mechanism for the activation of p53 by FL118.

The phenotyping department of PHENOMIN - ICS is advancing a technical platform for functional characterization of preclinical models of human diseases with respect to both genetic understanding of pathophysiological mechanisms and the assessment of drug therapies.

«Not only does this research provide compelling evidence for further investigation of immunotherapy for treating stomach cancer, it also provides the first model for preclinical testing of these treatments.»

FLX Bio to Highlight New Preclinical Data from CCR4 and USP7 Programs at the American Academy For Cancer Research (AACR) Annual Meeting Read more

I consider it a testament to our dedication and passion that we managed to get our first compound (an IDO1 inhibitor) in preclinical development in less than two years of operations, and I look forward to it entering clinical testing soon.

Several research institutions and companies have vaccine and drug candidates nearly ready to test, but until now a mouse model — a critical stage in preclinical testing — has not been available.

«There's a lot of preclinical work with a lot of potential.

Work experiences listed on sample resumes of Planning Managers include skills like providing recommendations regarding market potential for new targets including, but not limited to, indication prioritization and fast - to - market strategies, and providing commercial analysis in order to gain partnering opportunities for preclinical stage compounds.

He and his colleagues are seeking to test the ISP drug in preclinical trials.

After completion of his PhD, he worked in the pharmaceutical industry focusing on preclinical drug discovery for oncology.

«Evidence from preclinical research had previously indicated a relationship between solid tumors, immune response, and the microbiome.

The researchers are reporting preclinical findings for a potential two - treatment strategy to block multiple mechanisms of cancer cell metabolism in pancreatic cancer at the American Association for Cancer Research Annual...

Frost and Sullivan's survey showed that in 2002, the top 20 pharmaceutical companies spent about a third of their R&D budgets on preclinical development.

Even though the pharmaceutical industry uses preclinical data and predictive algorithms to weed out drugs that are likely to fail because of toxicity, many still slip through the cracks.

Nakano, a professor of neurosurgery and academic neurosurgeon at the University of Alabama at Birmingham, and Vito Coviello and Concettina La Motta, University of Pisa, Italy, are doing further preclinical evaluation of the GA11 and its analogs.

Promising compounds are being generated using established high throughput screening by medicinal chemistry and are being tested in preclinical animal models.

In the ensuing months, the two companies have published detailed, promising animal studies of their immunotherapies, including preclinical efficacy studies in animal models of human synucleinopathies.

New preclinical research provides support to a drug that has been repurposed to possibly treat a rare and extremely disabling genetic bone disease, particularly in children.

Over the course of its development, PNP has secured grants from the National Institutes of Health of approximately $ 10 million to support preclinical research at Southern Research Institute and UAB.

That is why drug trials are looking to recruit seniors with preclinical Alzheimer's who are on the verge of decline but otherwise look healthy.

Jones added that hope is on the horizon through preclinical trials that are testing several amphetamine - like drugs for effectiveness in treating cocaine addiction.

Such prophylactic vaccines against hepatitis C are still in preclinical phases, however.

Previously we reported the development of liposome - based vaccines and their efficacy and safety in preclinical mouse models for tauopathy.

This human data follows extremely promising preclinical data (much of which was reported at the previous year's San Antonio Breast Cancer Symposium) supporting the androgen receptor as a target in breast cancer.

APX005M and the Company's additional preclinical programs were discovered using APXiMABTM, Apexigen's proprietary product discovery platform.

While the Gladstone Institutes was established in 1979 as an independent, non-profit biomedical research institute, the Gladstone Center for Translational Research was established in 2006 to move its most advanced discoveries into preclinical development with biotechnology and pharmaceutical industry partners.

TauRx Therapeutics Ltd has reported preclinical study results, published online in Frontiers in Molecular... Read More

Gary Gintant, PhD, Abbvie, is optimistic that further advancements in the use of hiPSC - cardiomyocytes will significantly reduce the need for cardiovascular safety testing in animals, but there remains much to be learned about hiPSC - cardiomyocytes to understand the proper conditions for their use in preclinical safety testing.

Yet, this classic diagnostic strategy has widely recognized shortcomings that reflect both a lack of sensitivity in identifying preclinical disease and a lack of specificity in defining disease unequivocally.

As this special issue of BioProcess International goes to press, an increasing number of cell - based therapies are advancing through preclinical investigation into clinical development and on toward commercialization.

S.R.P. is a consultant for Pfizer vaccines and has a sponsored program on preclinical vaccine development with Merck.

The George lab is currently performing preclinical studies for the future development of novel therapeutic approaches including Deep Brain Stimulation, Optogenetics, Chemogenetics and Precision medicine.

Biomedcode is a highly innovative Contract Research Organization (CRO) which provides preclinical drug evaluation services to small and large pharmaceutical companies worldwide.

He was introduced to radiopharmaceutical development as a postdoctoral research associate and then as a staff scientist in the department of radiology at Washington University School of Medicine, where he developed several preclinical imaging agents to study brain tumors, atherosclerosis and Alzheimer's disease.

Investigators advance their discoveries through small - molecule - based drug discovery, an area where we have significant capabilities, into early preclinical therapeutic development.

An editorial in the same issue of the journal notes that drug - based treatments for liver cancer are limited and that the UT Southwestern study showed «truly remarkable results that should prompt further research under preclinical settings, given its potential to lead to a paradigm shift in treatment.»

These effects are considered to be beneficial and, therefore, in dogs with preclinical MMVD, it was anticipated that pimobendan would delay the onset of pulmonary oedema and clinical signs.

He further notes that there is ``... significant discordance between preclinical findings and clinical results» and ``... inefficient partnerships between academia and industry,» two challenges that must be addressed if academic research is to yield maximum clinical benefit and attain the ultimate goal of saving patients» lives.

«Future studies will aim to explore the relationship between SND1 and STAT3, identify additional microRNAs that may be relevant to malignant glioma and explore the effects of drugs that block SND1 expression in more advanced preclinical models.»