Sentences with phrase «preclinical data»

Xencor (XNCR)- The company announced intriguing preclinical data on XmAb24306, an IL15 / IL15 - receptor alpha complex fused to a bispecific XmAb Fc domain (IL15 / IL15Rα - Fc) for the treatment of multiple oncology indications.

Proclara Biosciences Presents New Preclinical Data Supporting Development of GAIM - Based Therapies at Society for Neuroscience Annual Meeting November 14, 2017

Seres Therapeutics (MCRB) Presents New Preclinical Data Supporting the Development of Microbiome Therapeutics for Immuno - Oncology at AACR

We have a large set of preclinical data of demonstrating that certain GLAAS formulations, when given prophylactically or therapeutically with or without the allergen, can shift the responses in a manner that results in significant protection from allergy symptoms.

Researchers publish preclinical data suggesting the promise of a novel drug directed against a novel target n malignant mammary tumors...

His research group actively collaborates with several pharmaceutical companies to provide valuable preclinical data in animal models for their targeted drugs.

Proclara Biosciences Presents Preclinical Data Supporting the Development of GAIM - Based Therapies for Peripheral Amyloidoses at the 16th International Symposium on Amyloidosis March 28, 2018

A team at Cold Spring Harbor Laboratory (CSHL) publishes preclinical data based on experiments conducted in mice suggesting the promise of a novel drug directed against a novel target in malignant mammary tumors.

FLX Bio to Highlight New Preclinical Data from CCR4 and USP7 Programs at the American Academy For Cancer Research (AACR) Annual Meeting Read more

Gosselies, Belgium - April 3, 2017 - iTeos Therapeutics SA, a biotechnology company developing novel cancer immunotherapies, will present preclinical data for its A2A receptor antagonist, which inhibits the immune suppressive function of adenosine, at the American Association for Cancer Research (AACR) Annual Meeting.

Even though the pharmaceutical industry uses preclinical data and predictive algorithms to weed out drugs that are likely to fail because of toxicity, many still slip through the cracks.

By the early 2000s, multi-stakeholder collaborations proliferated to address the need for important tools, such as biomarkers, that require preclinical data sharing.

This human data follows extremely promising preclinical data (much of which was reported at the previous year's San Antonio Breast Cancer Symposium) supporting the androgen receptor as a target in breast cancer.

The company is assembling preclinical data to determine whether LAMP nucleic acid constructs can amplify and activate the immune response in highly immunogenic tumor types.

«I am somewhat surprised and concerned, as I have not seen any peer - reviewed preclinical data on this approach,» he says.

In the United States, a panel convened by the National Academies of Sciences, Engineering, and Medicine has this year recommended that clinical trials of the technique be approved if preclinical data suggest that it is safe.

So similar are the two that researchers at the University of Georgia's Regenerative Bioscience Center have developed the first U.S. pig model for stroke treatments, which will provide essential preclinical data and speed the drug discovery process.

Preclinical data indicates that these cells promote blood vessel growth, modulate inflammation and reduce cell death.

NeuroPhage has accumulated extensive preclinical data on this candidate, demonstrating its efficacy across disease models of Alzheimer's and Parkinson's disease, tauopathies and other related diseases characterized by aggregation of amyloid beta, tau, and alpha - synuclein proteins.

Preclinical Data Showing Zika mRNA Vaccine Prevents In Utero Transmission Published in Cell: In July, data were published in Cell demonstrating that Moderna's Zika mRNA vaccine prevented Zika virus transmission from pregnant mice to their fetuses.

First Zika mRNA vaccine preclinical data published in Cell: In February, the first pre-clinical data for Moderna's Zika mRNA vaccine were published in Cell.

Together with the research and clinical resources of the nation's leading cancer hospital, we have the ability to take a program from a research hypothesis all the way to a clinical candidate supported by robust preclinical data, and into early phase clinical studies in well - defined patient populations.

Preclinical data strongly demonstrated that this combination provides robust and synergistic anti-tumor efficacy.»

New preclinical data reported in the Journal of Virology (Seay et al., 2015) use an engineered IL - 15 superagonist to activate human NK...

«Anti-Jason», please understand how silly it is to make statements such as «this company is at least worth X, because they have EXCELLENT preclinical data».

Under an existing collaborative research arrangement, Sanofi and Immune Design have generated a large set of preclinical data demonstrating that certain formulations within GLAAS, when given prophylactically or therapeutically, can shift the immune responses in a way that may result in significant protection and reduction from allergy symptoms.

However, preclinical data suggest that the proposed combination warrants further study.

However, preclinical data for this particular trial were not released.

Proclara Biosciences Presents Preclinical Data Supporting the Development of GAIM - Based Therapies for Peripheral Amyloidoses at the 16th International Symposium on Amyloidosis

All we have to go on is preclinical data in mice (and many of these mice are obese and raised in crowded cages6), and we must remember this, especially with patients and their families who are at wit's end because they are unable to effectively follow the diet.

Proclara Biosciences Presents New Preclinical Data Supporting the Development of NPT189 at Alzheimer's Association International Conference (AAIC) 2017 July 18, 2017

«Our preclinical data suggest that combining low doses of these inhibitors will enhance the clinical effects of both drugs as a potential treatment for patients with AML,» says the senior author, Feyruz V. Rassool, PhD, associate professor of radiation oncology at the University of Maryland School of Medicine (UM SOM) and a researcher at the University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center (UMGCCC).

«This preclinical data is extremely exciting,» he says.

Seres Therapeutics, Inc. (NASDAQ: MCRB) today announced that new preclinical data supporting the development of microbiome therapeutics for immuno - oncology (leveraging gut microbiota to impact tumor immunotherapy) 1 will be presented today by Sceneay et al in the late breaking poster session at the 2018 American Association for Cancer Research Annual Meeting (AACR) in Chicago.

Now, they've released the preclinical data behind the trial, showing the drug is effective in two animal models of HD.

[21] In the recently presented FLAURA study, in which osimertinib was used in untreated patients with advanced EGFR - mutant NSCLC, the HR for systemic disease control and CNS control similarly favored osimertinib over erlotinib or gefitinib, supporting the preclinical data that showed osimertinib's penetration across the BBB and providing support for using this agent in first - line management of EGFR - mutant patients with brain metastases.

Preclinical data have demonstrated that radiation increases EGFR expression and that blocking EGFR in vitro sensitizes cells to radiation.

In an effort to further exploit the potential of Pexa - Vec to activate the immune system to fight cancer, as seen in McDonald's preclinical data, SillaJen recently announced a new clinical trial in collaboration with New York - based Regeneron Inc. to test Pexa - Vec and REGN2810, a PD - 1 checkpoint inhibitor, in combination against renal cell carcinoma, and recently signed a sponsored research agreement with UCSF to enable joint support of parallel preclinical experiments by McDonald's team.

«The preclinical data to be presented further demonstrate the potential of our insurmountable and non-brain penetrant A2A receptor antagonist in combination with immune checkpoints.

The comprehensive information presented for each cell therapy includes: an overview of the therapy, a list of therapeutic cells utilized in the specific treatment, mode and regimen of cell delivery, mechanism of action, formulation, in vitro data, animal models, preclinical data and related clinical trials.

Our preclinical data on DG041 were very encouraging and we look forward to sharing with you the results of this trial in a few months time,» said Kari Stefansson, CEO of deCODE.

«We are encouraged by the preclinical data emerging on SRK - 015, including the effects upon fast - twitch muscle fibers that are particularly relevant for SMA as well as its selectivity profile, which may be very important when considering chronic therapy in children,» said Karen S. Chen, PhD, Chief Scientific Officer of the SMA Foundation and a co-author of the study being presented at the Cure SMA Annual Conference.

From the amount of preclinical data that accumulates on a daily basis, several key facts are emerging regarding the potential of dietary manipulation and a ketogenic diet in the treatment of cancer...

The past century has unveiled a plethora of preclinical data that has suggested the potential of a ketogenic diet as an aid in cancer treatment.7, 8

The past century has unveiled a plethora of preclinical data that has suggested the potential of a ketogenic diet as an aid in cancer treatment.7, 8 The benefits of a ketogenic diet, and dietary manipulation in general, may be a potent adjunct to current cancer treatments by synergistically working with chemotherapy and radiation therapy to starve cancer cells, leaving them more susceptible to damage from these treatments.7 - 10

The preclinical data is compelling, but this data is in animals.

The preclinical data is exciting, but unfortunately, we still have a long way to go.