Sentences with phrase «preclinical evidence of»

Preclinical evidence of Alzheimer's disease in persons homozygous for the e4 allele for apolipoprotein E. NEJM 1996; 334 (12): 752 - 758.

Osimertinib showed preclinical evidence of concentrations in mouse brain tissue 5 - to 25-fold higher than in plasma, [16] and has shown greater penetration of the BBB in mouse models than gefitinib, rociletinib, or afatinib.

Not exact matches

«For the first time, scientists have attempted to account for numbers of people with biomarkers or other evidence of possible preclinical Alzheimer's disease, but who do not have impairment or Alzheimer's dementia.

These preclinical findings, published online ahead of print in the International Journal of Oncology, provide evidence for a potential therapeutic approach that will restore sensitivity to chemotherapy and improve treatment of inflammatory breast cancer tumors.

«What we discovered in our preclinical work is evidence of how groups of neurons coordinate and cooperate with each other in a very particular way that gives us deeper insight into how the brain is controlling the arm,» Shenoy said.

Medicinal cannabis use is booming for many disorders, the authors of the paper said, even without enough preclinical evidence or sufficient insights into its mechanism of action.

Their findings confirm preclinical evidence that the agent, which is derived from salmonella flagellin, is worthy of further investigation as treatment for some of the most common and most resilient solid - tumor cancers.

«Preclinical evidence suggests that dietary interventions, such as calorie restriction, intermittent fasting, low - fat diet and the ketogenic diet, have the potential to reverse some of these obesity - associated alterations; however, more clinical data are needed to confirm translation to human subjects.»

Of note, nearly 38 percent of people between ages 65 to 75 years and 43 percent of those older than age 75 years had evidence of preclinical HF stage B. Additionally, 32 percent of people less than 55 years of ages were classified as stage A HF,» explained corresponding author Vanessa Xanthakis, PhD, assistant professor of medicine and biostatistics at BUSM and an Investigator for the Framingham Heart StudOf note, nearly 38 percent of people between ages 65 to 75 years and 43 percent of those older than age 75 years had evidence of preclinical HF stage B. Additionally, 32 percent of people less than 55 years of ages were classified as stage A HF,» explained corresponding author Vanessa Xanthakis, PhD, assistant professor of medicine and biostatistics at BUSM and an Investigator for the Framingham Heart Studof people between ages 65 to 75 years and 43 percent of those older than age 75 years had evidence of preclinical HF stage B. Additionally, 32 percent of people less than 55 years of ages were classified as stage A HF,» explained corresponding author Vanessa Xanthakis, PhD, assistant professor of medicine and biostatistics at BUSM and an Investigator for the Framingham Heart Studof those older than age 75 years had evidence of preclinical HF stage B. Additionally, 32 percent of people less than 55 years of ages were classified as stage A HF,» explained corresponding author Vanessa Xanthakis, PhD, assistant professor of medicine and biostatistics at BUSM and an Investigator for the Framingham Heart Studof preclinical HF stage B. Additionally, 32 percent of people less than 55 years of ages were classified as stage A HF,» explained corresponding author Vanessa Xanthakis, PhD, assistant professor of medicine and biostatistics at BUSM and an Investigator for the Framingham Heart Studof people less than 55 years of ages were classified as stage A HF,» explained corresponding author Vanessa Xanthakis, PhD, assistant professor of medicine and biostatistics at BUSM and an Investigator for the Framingham Heart Studof ages were classified as stage A HF,» explained corresponding author Vanessa Xanthakis, PhD, assistant professor of medicine and biostatistics at BUSM and an Investigator for the Framingham Heart Studof medicine and biostatistics at BUSM and an Investigator for the Framingham Heart Study.

The aim of the project is two-fold: to provide evidence about reproducibility in preclinical cancer research, and to identify the factors that influence reproducibility more generally.

The meeting focused on evidence from preclinical models and patients that indicate SMN has a role outside of the CNS -LSB-...]

AZD3759, an EGFR inhibitor with blood brain barrier (BBB) penetration for the treatment of non-small cell lung cancer (NSCLC) with brain metastasis (BM): preclinical evidence and clinical cases.

«Lithium, long used in mental health as a highly effective mood stabiliser, has been on the radar as a potential disease modifying treatment for Alzheimer's disease with positive evidence from preclinical studies and a number of small clinical trials.

«Not only does this research provide compelling evidence for further investigation of immunotherapy for treating stomach cancer, it also provides the first model for preclinical testing of these treatments.»

The meeting focused on evidence from preclinical models and patients that indicate SMN has a role outside of the CNS and the implications of these data for systemic treatment of SMA.

«The findings of this preclinical study contribute significantly to our understanding of SMA and provide further evidence suggesting that our strategy to upregulate SMN with small molecules could be effective,» said Loren Eng, President of the SMA Foundation.

This slow decline in brain glucose usage can be seen as a kind of «canary in the coal mine» — preclinical evidence that something has gone awry long before damage has progressed to the point of overt signs and symptoms.

To determine whether chronic oral administration of pimobendan in dogs with evidence of increased heart size secondary to preclinical myxomatous mitral valve disease (MMVD) can delay the onset of clinical signs of congestive heart failure (CHF).1

Consistent with preclinical studies, adults with depression have been reported to have multiple alterations of the hypothalamic pituitary adrenal axis (9), increased cerebrospinal fluid corticotropin - releasing hormone (10), elevated cerebrospinal fluid norepinephrine concentration (11), decreased cortical γ - aminobutyric acid measured in vivo using proton magnetic resonance spectroscopy (12), and multiple indicators of altered serotonin (5 - HT) functioning (13), including reduced serotonin transporter (5 - HTT) availability as evidenced by reduced [123I] β - CIT spect binding (14).

There is now ample evidence from the preclinical and clinical fields that early life trauma has both dramatic and long - lasting effects on neurobiological systems and functions that are involved in different forms of psychopathology as well as on health in general.