Sentences with phrase «preclinical findings in»

The study chronicles the use of Vasalgel ™ in groups of rhesus macaques — confirming previous preclinical findings in rabbits on the efficacy of the new device and offering a new tool to colony managers.

Not exact matches

Looking at sixty - seven recent drug discovery projects based on preclinical cancer biology research, they found that in more than 75 percent of cases the published data did not match up with their in - house attempts to replicate.

These preclinical findings, published online ahead of print in the International Journal of Oncology, provide evidence for a potential therapeutic approach that will restore sensitivity to chemotherapy and improve treatment of inflammatory breast cancer tumors.

Now, a new preclinical study from Penn Medicine researchers found that in many cases the root of the resistance may lie in a never - before - seen autophagy mechanism induced by the BRAF inhibitors vermurafenib and dabrafenib.

Now, a preclinical study, from the lab of Olivier Berton, PhD, an assistant professor in the department of Psychiatry, in collaboration with Sheryl Beck, PhD, a professor in the department of Anesthesiology at Children's Hospital of Philadelphia, found that bullying and other social stresses triggered symptoms of depression in mice by activating GABA neurons, in a never - before - seen direct relationship between social stimuli and this neural circuitry.

Combining their strategy with an existing immunotherapy treatment that works by releasing the «brakes» on immune cells, they found they could shrink melanoma tumors, and prolong survival in preclinical models for melanoma.

The study can be seen in Cell Reports and provides an explanation for why the clinical trials for Alzheimer's disease drugs have failed and gives new light on the discord between preclinical and clinical findings.

Scientists have found a way to target elusive cells that suppress immune response, depleting them with peptides that spare other important cells and shrink tumors in preclinical experiments, according to a paper published online by Nature Medicine.

Published this week in the journal Proceedings of the National Academy of Sciences, the scientists found that inhibiting activin A, activin B and myostatin resulted in skeletal muscle mass increase by as much as 150 per cent in preclinical models.

The findings of multiple in vivo preclinical studies published online in Blood Advances, a Journal of the American Society of Hematology (ASH), indicate that this therapy could potentially treat multiple cancers, including non-Hodgkin lymphoma (NHL), multiple myeloma (MM), and acute myeloid leukemia (AML).

A preclinical study led by researchers in the United States has found that a new oral drug shows early promise for the treatment of muscular dystrophy.

«While care must be taken in extrapolating preclinical findings to the care of particular patients, we believe that these and other data do support a more comprehensive and perhaps holistic approach to caring for patients with diabetes and / or obesity,» he adds.

A few years ago, two pharmaceutical companies reported that they could not replicate the vast majority of academic findings in preclinical experiments.

«We are pleased to have obtained the same results in two different laboratories and we look forward to translating these preclinical findings into combination approaches with entinostat to enhance the clinical activity of immune checkpoint inhibition.»

Verma, whose team will publish its findings tomorrow in Nature, says the findings emphasize the need for longer preclinical studies.

«The next step is to perform preclinical studies with specific inhibitors of HDAC11 alone and in tandem with other existing immunotherapies, such as anti-PD1 / anti-PDL1 antibodies, in order to find the most potent combination.

Our finding of similarity in clinical progression between human patients and Huntington's disease monkeys suggests monkeys could become a preclinical, large animal model for the development of new treatments.»

We predicted that MP's behavioral effects in marijuana abusers would be attenuated, consistent with preclinical findings (30), and that decreased DA reactivity in ventral striatum would be associated with higher scores in negative emotionality (neuroticism), which mediates genetic risk for marijuana dependence (31), and with addiction severity.

They found that injecting patient - derived, brain - seeking melanoma cells into the carotid artery of these preclinical models resulted in the formation of many metastatic tumors throughout the brain, mimicking what is seen in advanced melanoma cancer patients.

Based on these preclinical findings, CRI provides a seed grant for a phase I clinical trial to test the strategy in patients with metastatic renal cell carcinoma.

PNP Therapeutics, Inc. — a company based on a gene - therapy technology developed by scientists at Southern Research Institute and the University of Alabama at Birmingham (UAB)-- has found an approach that has abolished otherwise unmanageable human cancers in preclinical rodent studies.

The findings discovered in animal models are translated into preclinical mechanism - driven prevention studies that will ultimately inform epidemiologic studies and lead to clinical trials in humans.

The potential of Tumor Paint is not limited to brain tumors; it has been found in preclinical studies to light up prostate, colon, breast and other cancers.

Hu H, Gomero E, Bonten E, Gray JT Allay J, Wu Y, Wu J, Calabrese C, Nienhuis A, d'Azzo A. Preclinical dose - finding study with a liver - tropic, recombinant AAV - 2 / 8 vector in the mouse model of galactosialidosis.

Earlier research by the Wash U team found that people with preclinical Alzheimer's spent a higher percentage of their time in bed unable to fall asleep.

[13] Highlighting this risk in the PD / AS context, a preclinical study using a nitrated AS species similar to one found in patient LB as an active vaccine antigen developed worrisome autoimmunity.

Scientists and vaccine developers involved in EVI projects presented project progress and research findings, highlighting one of the most important areas of EVI's activities; translation of research on diseases of poverty vaccines, focusing on early stages from preclinical to clinical development through harmonisation.

The lab used MRS in a preclinical study of SAPAP3 knockout mice — which model aspects of human obsessive compulsive and related disorders (OCRD)-- to determine whether these mice exhibit neurochemical abnormalities found in humans with OCRD.

The researchers are reporting preclinical findings for a potential two - treatment strategy to block multiple mechanisms of cancer cell metabolism in pancreatic cancer at the American Association for Cancer Research Annual...

Southern Research Institute is a not - for - profit 501 (c)(3) scientific research organization founded in 1941 that conducts preclinical drug discovery and development, advanced engineering research in materials, systems development, and environment and energy research.

This preclinical work led to the development of a novel anti-androgen ARN - 509, a small - molecule inhibitor discovered in collaboration with UCLA chemist Michael Jung, which targets the increased levels of androgen receptor found in hormone - refractory disease.

«We found that fragmentation of the circadian rhythm — meaning when someone had frequent short periods of rest or sleep during the day, and frequent brief periods of activity at night — was associated with preclinical Alzheimer's disease,» said Dr. Yo - El S. Ju of the Washington University School of Medicine in St. Louis.

However, ADCs that use derivatives of calicheamicin, which promotes double - stranded DNA breaks, such as GO and inotuzumab ozogamicin, 40,41 have limited activity in cells with high multidrug resistance protein activity, a phenotype found in a significant fraction of AML patients.42 Another ADC, SGN - CD123A, comprising an engineered form of the CD123 - targeting 7G3 antibody conjugated to a synthetic pyrrolobenzodiazepine dimer, which acts via DNA crosslinking, has entered clinical trials after showing robust activity in preclinical models of AML, including those with multidrug resistance.33

This corroborates the use of feature binding tests in preclinical AD studies and suggests that specific cognitive deficits can be found in SCD.

EPIC findings suggest that early treatment of preclinical MMVD delays onset of CHF in dogs.

Given emerging preclinical and clinical findings demonstrating the importance of both genetic and environmental (e.g., care giving and social supports) factors in determining the consequences of early stress, we examined the moderating role of the 5 - HTTLPR and social supports on the development of depression in maltreated children.